Volume 22, Issue 135 (9-2015)                   RJMS 2015, 22(135): 115-121 | Back to browse issues page

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Effect of various doses of Lavandula officinalis on acute pain in rat. RJMS. 2015; 22 (135) :115-121
URL: http://rjms.iums.ac.ir/article-1-3946-en.html
Abstract:   (2894 Views)

Background: The use of medicinal plants is important in reducing pain. Extracts obtained from the leaves of Lavandula officinalis (Lamiaceae) are used in Iranian folk medicine as remedies for anti-nociceptive effects. This study was aimed to investigate the effects of pretreatment with different doses of Lavandula officinalis ethanolic extract on hot plate induced nociception in male Wistar rats.

Methods: This experimental study was carried out on 28 male Wistar rats weighing 200-250 g. Acute pain was investigated using a hot plate test with set point 52.8 °C and cut off time of 60 seconds. In this experiment rats were divided into 4 groups. Control group received distilled water and three treatment groups received different doses of lavender ethanolic extract (100, 200, 400 mg/kg, respectively) 1 hour prior beginning of experiment via gastric gavage. The data were compared using one way ANOVA (post hoc LSD).

Results: Lavender extract with 400 mg/kg dose significantly increased latency to respond to heat stimulus 5 and 15 minutes after beginning of the experiment.

Conclusion: Although further studies are needed, the results indicate that lavender extract might be beneficial in patients suffering pain.

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Type of Study: Research | Subject: Pharmacology

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