Volume 3, Issue 1 And 2 (9-1996)                   RJMS 1996, 3(1 And 2): 183-183 | Back to browse issues page

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Leonard B. SROTPECER RECEPTORS AND THEIR POSSIBLE FUNCTION IN THE BRAIN. RJMS 1996; 3 (1 and 2) :183-183
URL: http://rjms.iums.ac.ir/article-1-1845-en.html
Abstract:   (11724 Views)

Thirty-three Years ago, Gaddum and Picarelli classified the serotonin receptors in the guinea pig ileum into D and M types based on the activity of dibenzyline (D) and morphine (M) to block contractions of intestinal smooth muscle caused by serotonin. The subsequent location of specific ligand binding sites for serotonin in the brain has led to the identification of ten serotonin receptor sub-types in rat brain. The cloning of these receptor sub-types has been of importance in enabling them to be classified as specific protein molecules encoded by specific genes. The problem now arises with regard to the linking of the changes in the cellular activity of the various receptor sub-types with the plethora of behavioural changes that arise as a consequence of the actions of serotonin in the brain.

The present review summarizes the evidence implicating the role of specific serotonin receptor sub-types in sleep, anxiety states, schizophrenia and depression. A summary of the relationship between these receptor sub-types and their possible involvement in the aetiology of these diseases is also given.

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Type of Study: Research | Subject: Pharmacology

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