2024-03-29T17:57:25+04:30 http://rjms.iums.ac.ir/browse.php?mag_id=56&slc_lang=en&sid=1
56-1533 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 The Healing Effect of Lactobacillus plantarum Isolated from Iranian Traditional Cheese on Acetic Acid Induced Gastric Ulcer in Rats H Aboutalebi M Heydari Nasrabadi M Tajabadi Ebrahimi M Shabani F Zahedi Background: Probiotics are defined as “living organisms which upon ingestion in certain numbers, exert health benefits beyond inherent basic nutrition". One of the most significant groups of probiotic organisms are the lactic acid bacteria, commonly used in fermented dairy products. The actions of lactic acid bacteria are species and strain specific and depend on sufficient numbers of bacteria being available in the intestine. The difficulty in identifying and classifying strains has complicated researches, since benefits may only pertain to particular strains. The aim of the present study is to investigate the effect of a probiotic strain Lactobacillus plantarum isolated from Iranian traditional cheese on gastric ulcer healing.Methods: In this experimental study 22 strains of lactic acid bacteria isolated from Iranian traditional cheese were investigated for Exopolysaccharide (EPS) production by phenol-sulfuric acid method which had been approved earlier for the ability of survival and growth in digestive system. To determine the effect of this probiotic strain, male wistar rats were divided into 3 groups experimental, control and negative control. Rats were deprived of food but not water for 24 hours and gastric ulcers were induced by luminal application of 0.12 ml acetic acid solution (60% v/v). One day after ulcer induction, the experimental groups received sterilized milk with Lactobacillus plantarum at concentration of 1×1010cfu/day, the control groups received sterilized milk and the negative control groups received normal saline through oral gavage for few consecutive days. Rats were sacrificed on days 5 and 14 after ulcer induction and the ulcer sizes (mm2) were summed. After histological study the effect of this probiotic on gastric ulcer healing was determined in each stomach. Data were analyzed with One way ANOVA test and all results were reported as Mean ± SEM.Results: Lactobacillus plantarum significantly decreased gastric ulcer area compared to control and negative control groups and increased ulcer healing. Histological study on day 5 after ulcer induction showed significant reduction in number of neutrophils and significant increases in macrophages and fibroblasts (p<0.001). Also significant reduction in the number of neutrophils, macrophages and fibroblasts was observed on day 14 after ulcer induction (p<0.001).Conclusion: Lactobacillus plantarum showed significant effects on gastric ulcer healing induced by acetic acid in rats. Keywords: 1) Probiotics 2) Lactobacillus plantarum 3) Gastric ulcer 4) Healing 2010 11 01 7 16 http://rjms.iums.ac.ir/article-1-1533-en.pdf
56-1534 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 Evaluation of Vaginal Fluid β-HCG for Diagnosis of Premature Rupture of Membranes Sh Baha Sadri M Kashanian Sh Khalili Background: Premature Rupture Of Membranes (PROM) is one of the most important problems of pregnancy and accurate diagnosis of suspicious cases is under special concern. In this regard, researches are being conducted in order to find a reliable, fast and simple method for accurate diagnosis. The purpose of the present study is to evaluate vaginal fluid β-HCG for diagnosis of PROM.Methods: An observational cross sectional study was performed on 123 pregnant women who were in the third trimester of gestation (gestational age more than 28 weeks of pregnancy). The patients were considered in 3 groups including:  PROM group (41 cases), suspicious for PROM (42 cases) and intact membranes (40 cases). Five ml sterile normal saline was introduced in  to the posterior fornix of vagina,   then vaginal  fluid was aspirated and sent to the laboratory for β-HCG measurement. Finally, the amount of β-HCG was compared in the 3 groups. For data analysis student t-test, One way Anova and Kruskal Walis tests were used. SPSS V.11.5 was also used.Results: β-HCG concentration was 7.71±15.7 mIU/ml in the intact membrane group, 468.06±366.34 mIU/ml in the PROM group and 176.43± 316.37 mIU/ml in the suspicious group which showed a significant difference between the 3 groups (p=0.000). In order to find an optimal Cut off value for β-HCG, Receiver Operating Characteristics Curve (ROC) was used and a Cut off value of 79.5 mIU/ml with a sensitivity of 95% and specificity of 84% was determined to be optional.Conclusion: β-HCG is higher in PROM and suspicious for PROM patients, and thus may be used as a suitable, fast and reliable test for detecting PROM.  Keywords: 1) Premature rupture of membranes (PROM) 2) Beta- HCG(β-HCG) 3) Amniotic membranes 4) Vaginal fluid 5) Pregnancy 2010 11 01 17 23 http://rjms.iums.ac.ir/article-1-1534-en.pdf
56-1535 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 Results of Femoral Artery Ligation in Intravenous Drug Abusers with Infected Femoral Artery Pseudoaneurysms in Hazrat-e-Rasool Akram Hospital, 1991 - 2006 M Khavaninzadeh A Molayem S Farshi Background: Infected femoral artery pseudoaneurysm is one of the important domains in vascular surgery and femoral pseudoaneurysms has been under focus in particular because of its increasing rate in Intravenous Drug Abusers (IVDAs) and occurrence following common vascular procedures. In this article we assessed the results of femoral artery ligation in patients with femoral pseudoaneurysms. Methods: In this retrospective case series, we studied 21 patients with femoral pseudoaneurysms whom underwent femoral ligation without revascularization in Hazrat-e-Rasool Akram hospital, Tehran from Jan 1991 to Dec 2006. We  used patient’s medical records for data collection. The analyses were performed using SPSS V.12. and Chi-squre test. Results: From the total of 21 patients 20 were male (95%) and 1 patient was female (5%). Mean age was 37.74± 9.4 years. All patients were IV drug abuser. Mean hospital stay was 9.8 ± 9.4 days. Mean of interval between surgery to mobility was 3.89±1.2 days. Claudication was the most prevalent complication of surgery (31.2%). Amputation was done only in 2 patients and there was not any mortality.Conclusion: Femoral artery ligation is relatively safe and feasible method for treatment of  IV drug abusers as they have the  tendency to develop collateral arteries, are at risk for recurrence of pseudoaneurysms (due to IV abuse) and difficult to follow-up. Keywords: 1) Femoral pseudoaneurysm 2) Intravenous drug abusers 3) Ligation 2010 11 01 25 31 http://rjms.iums.ac.ir/article-1-1535-en.pdf
56-1536 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 The Effect of Amino Acids on the Growth of Trichophyton rubrum and Trichophyton verrucosum M.R Sarasgani M Firoozrai Background: Amino acids have different effects on the growth of dermatophytes. Some may encourage growth while others may inhibit it. These effects not only depend on the type of the amino acid but also on the amino acid concentration and type of the dermatophyte. The aim of this study was to investigate the effects of amino acids on the common dermatophytes in Iran.Methods: In this experimental study, two common dermatophytes namely Trichophyton verrcusom and Trichophyton rubrum were selected. They were grown on Sabouraud  glucose agar media that contained various concentrations of 23 amino acids. The experiment was carried out three times . After two-three weeks, the diameter of the colonies were measured and compared with the controls that had no amino acids added to the Sabouraud glucose media. Data were analyzed by t-student test. SPSS V.9 was used for data analysis.Results: The results showed that L-cysteine hydrochloride, L-cysteine, L-aspartic acid, L-glutamic had the most inhibitory effects on the studied dermatophytes. Trichophyton verrcusom, but not Trichophyton rubrum, was resistant to DL tryptophan. Arginine, Lysine monocholoride and L-methionine had milder inhibitory effects on both dermatophytes. Serine also had moderate inhibitory effect only against Trichophyton verrcusom. Seven amino acids including L-Cystine, Cysteine hydrochloride, Thereonine, Valine, Glutamine, Leucine and Isoleucine have stimulatory effects only on Trichophyton verrcusom in 0.1 gr/dl concentrations. Non of the amino acids mentioned could stimulate the growth of Trichophyton rubrum.Conclusion: This study indicates that Trichophyton verrcusom and Trichophyton rubrum have different sensitivities towards amino acids this difference being important in regards to DL tryptophan.  This difference could be used to differentiate Trichophyton verrcusom. Keywords: 1) Amino acids 2) Dermatophytes 3) Trichophyton rubrum 4) Trichophyton verrcusom 2010 11 01 32 39 http://rjms.iums.ac.ir/article-1-1536-en.pdf
56-1537 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 Comparison of the Qualitative and Quantitative Indexes of Scientific Medical Journals Affiliated to Iran University of Medical Sciences with Iranian Exemplary Medical Journals during 2008-2010 S.M Fereshtehnejad S.A Motevalian M Moradi Lakeh S Aghili A Shafiee Sabet Background: Regarding the increasing number of publications of researchers in medical sciences, an increased tendency toward scientific medical journals is seen in Iran. Besides the growing number of these journals, it is of great importance to monitor and control their quality. Therefore, this study was designed to evaluate the qualitative and quantitative indexes of all 7 scientific medical journals affiliated to Iran University of Medical Sciences (IUMS) and to compare these indexes with the ones in Iranian exemplary medical journals during 2008-2010.     Methods: This analytical cross-sectional study was performed on all 7 medical journals (including 5 Persian-language and 2 English-language journals) of IUMS (overall number of 40 issues) and 5 Iranian exemplary medical journals from Razi Research Festivals during 2008-2010 as the control group (overall number of 24 issues). Then, several qualitative and quantitative indexes were assessed and compared between these two groups of medical journals.     Results: Analytical and descriptive cross-sectional studies were the most common type of study designs in most of the IUMS journals while this prevalence was significantly higher than control group (p<0.05). More than 60% of the published articles in Iranian exemplary medical journals were derived from approved projects or research grants whereas, this prevalence was less than 50% in all 7 journals of IUMS group. The mean duration between acceptance and publication time was approximately 3.5 months in control group, while it lasted as long as 10 and 10.5 months in Medical Journal of IUMS and Iranian Journal of Psychiatry and Psychology (IJPP), respectively (both p<0.001).    Conclusion: The strong and weak points of each medical journal of IUMS were evaluated in this study. In order to improve the quality of IUMS scientific journals, it seems necessary to revise some visions and missions of these journals including giving priority to other-organization’s articles (rather than IUMS), research grant-derived manuscripts, clinical trials’ findings, decreasing duration of peer review and publishing processes. Also indexing in ISI and/or MEDLINE could attract higher qualified articles of national and international authors to be published in scientific journals of IUMS.          Keywords: 1) Scientific medical journal 2) Iran university of medical sciences 3) Qualitative index 4) Quantitative index 2010 11 01 40 54 http://rjms.iums.ac.ir/article-1-1537-en.pdf
56-1538 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 Evaluation of the Effect of Kegel Exercise and Kegel Master Device on the Urinary Incontinence in Women of Reproductive Age and a Comparison between them M Kashanian SH Shah Ali M Nazemi SH Baha Sadri Background: Urinary incontinence is one of the most common complaints in women that can has serious influence on the quality of their lives. The purpose of the present study is to evaluate the effect of Kegel exercise with and without Kegelmaster device on the Stress Urinary Incontinence (SUI) in women and making a comparison between these two methods.Methods: A randomized clinical trial was performed on 91 women with the complaint of urinary stress incontinence. They were randomly assigned into two groups. In the case group ( n= 41), Kegel master device was  used and in the control group ( n= 50), Kegel exercises were done. For data analysis Mann-Witney, Wilcoxson, independent t and pair t tests were used. SPSS V.11 was also used. Results: In this study, 85 women out of 91 women finished the study(46 in the control group and 39 in the case group).Strength of pelvic floor muscles, capability to participate in the social activities, score of quality of life according to 3 world questionnaires of  IQOL(Incontinence – quality of life),  IIQ (Impact Questionnaire Incontinence), and UDA(Urogenital Distress Inventory) were not different between the 2 groups 1 and 3 months after interventions, but severity of urinary incontinence showed significant difference between the two groups( p= 0.007).Pair t test showed a significant improvement in both groups in regard to strength of pelvic floor muscles (p=0.000), capability to participate in the social activities (p=0.000), severity of urinary incontinence (p=0.000) and the number of involuntary urine passage(p=0.000) 3 months after intervention according to IQOL score(p=0.000), UDI score (p=0.000), IIQ score(p=0.000).Conclusion: Pelvic floor exercise with or without special devices are effective for improvement of urinary incontinence in women, but these 2 methods are not apparently different from each other. Keywords: 1) Urinary incontinence 2) Quality of life 3) Kegel master device 4) Pelvic floor exercise (Kegel) 2010 11 01 55 66 http://rjms.iums.ac.ir/article-1-1538-en.pdf
56-1539 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 Evaluation of the Accuracy of Bedside Ultrasonography in the Diagnosis of Pneumothorax in Suspicious Cases Admitted in Hazrat-e-Rasool Akram Hospital during 2008 M Mashayekhian S Abbasi D Farsi M Jafarinadushan H Saeedi M Zare Background: Pneumothorax may be associated with penetrating or blunt chest traumas' that need early diagnosis and treatment. Today the diagnosis modalities are CXR and CT-Scan that are not suitable for unstable patients. Chest sonography can be a fast diagnostic method at patient bedside. The purpose of this study was to evaluate the accuracy of bedside ultrasonography in diagnosis of pneumothorax.Methods: In this prospective study, 60 cases suspicious of pneumothorax were included in study. Bedside ultrasonography was performed for all the cases. Sonography site was between parasternal and midclavicular lines in 2nd to 4th intercostals spaces of both thoracic sites and performed between 5-10 respiratory cycles. Gold standard results for definite diagnosis were: positive results of chest X ray, chest CT scan and/or air leak after needle or tube thoracostomy. In suspicious results, CT scan was done. Data were analyzed accordingly with statistic tests of “Chi-Square” and “Fisher’s Exact Test”. SPSS V.12 was also used.Results: Trauma mechanism in 5 cases (8.3%) was stab wound, and in 53 cases(88.3%) multiple trauma there was 1 case of tuberculosis and 1 case of blunt chest trauma as well. Eleven out of the 12 pneumothorax cases (proven by chest Xray or CT scan) were diagnosed by bedside sonography. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of bedside ultrasonography for diagnosis of pneumothorax were 91.6%, 100%, 100%, 97.9% and 98.6%, respectively.Conclusion: With respect to the results of this study and previous studies, bedside ultrasonography is a good method for diagnosis of pneumothorax. Keywords: 1) Ultrasonography 2) Pneumothorax 3) Chest X ray 4) Chest CT-scan 2010 11 01 67 73 http://rjms.iums.ac.ir/article-1-1539-en.pdf
56-1540 2024-03-29 10.1002
Razi Journal of Medical Sciences RJMS 2228-7043 2228-7051 2010 17 77 The Frequency Assessment of Deep Vein Thrombosis and its Associated Risk Factors in Patients Undergoing Neurosurgical Procedures R Molahosseini Kahnoji M Nikoobakht Background: The aim of this study was to establish the frequency of Deep Vein Thrombosis (DVT) and its associated risk factors in patients undergoing neurosurgical procedures. Methods: In a cross-sectional study, 590 consecutive adult patients who underwent neurosurgery in Firoozgar Hospital between March 2006 and 2010 were enrolled. All patients underwent Doppler sonography examination of the lower limbs to establish the presence of DVT when they were about to be discharged. Then all risk factors were assessed in patients. Data was analyzed using Chi square, Fisher's exact test and Independent samples t-test. SPSS V.16.0 was also used. Results: The frequency of DVT in neurosurgery ward was 20.41% (with 95% confidence interval from 17.14% to 23.68%). The frequency of patients with age>40, malignant brain and spinal tumors, history of DVT, cigarette smoking, OCP consumption or pregnancy, heart failure and those with signs of DVT were significantly higher in patients with DVT. Also the mean of BMI, duration of surgery and complete best rest was significantly higher in DVT group. Conclusion: The overall frequency of postoperative DVT in our population was not significantly different from the best results of other studies and the high-risk groups were similar. Most of them were subclinical and potentially life-threatening. Considering the high frequency of DVT among these patients, it seems that assessing patients with one or more risk factors by Doppler sonography would be beneficial to promptly find and treat the condition. Keywords: 1) Frequency 2) Deep vein thrombosis 3) Risk factors 4) Neurosurgery 2010 11 01 74 80 http://rjms.iums.ac.ir/article-1-1540-en.pdf