Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
The effect of bilateral vasectomy on the serum levels of Prooxidant-Antioxidant Balance (PAB) and lipid peroxidation in rat
1
6
FA
Azita
Faramarzi
Tehran University of Medical Sciences
N
Behjat
Seifi
Tehran University of Medical Sciences
N
Mahsa
Sohani
Tehran University of Medical Sciences
N
Hamid Reza
Sadeghipour Rodsari
Tehran University of Medical Sciences
Y
Background: Vasectomy is a widespread contraceptive method in men. In recent years, the number of men who perform vasectomy reversal is increasing. Vasectomy has complications, probably leading to vasectomy reversal failure. It is assumed that oxidative stress is the main cause of these complications. The aim of this study was to investigate the indices of oxidative stress serum after vasectomy. Methods: In this experimental study, 42 male rats were divided in 6 groups of seven each: bilateral vasectomy (15, 45 and 90 days) and sham (15, 45 and 90 days) groups. Serum PAB (Prooxidant-Antioxidant Balance) and MDA (Malondialdehyde) as a product of lipid peroxidation were measured 15, 45 and 90 days after intervention. Comparisons between groups were made by Repeated Measure test. Results: Our result showed that serum MDA increase after 15 days was not significant (2.95 ± 0.12) in comparison to related sham group, but after 45 (3.6 ± 0.12) and 90 (3.9 ± 0.31) days the increase, compared to related sham groups 45 (2.28 ± 0.28) and 90 (2.29 ± 0.25)days, and also 15 days vasectomy group (2.95 ± 0.12) were significant (p< 0.001), and there was no significant increase in serum PAB at any times (p > 0.05). Conclusion: Bilateral vasectomy increased serum levels of MDA. It is supposed that increase in MDA causes adverse effects and unsuccessful reversal vasectomy. By prescribing antioxidants, these effects can be decreased.
Vasectomy, Prooxidant-antioxidant balance, Malondialdehyde, Rat.
http://rjms.iums.ac.ir/article-1-2023-en.html
http://rjms.iums.ac.ir/article-1-2023-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
Assessment of effect of shift work on blood pressure in workers of a rubber manufacturing company
7
14
FA
Majid
Golabadi
Tehran University of Medical Sciences
N
Faezeh
Dehghan
AJA University of Medical Sciences
N
Farnaz
Safakhah
Tehran University of Medical Sciences
N
Mir Saeed
Attarchi
Tehran University of Medical Sciences
Y
Background : Various factors such as occupational and environmental risk factors affect blood pressure. Nowadays, shift work is a common work schedule. Studies on effect of shift work on hypertension showed different results. We studied the effect of shift work on hypertension and pre-hypertension among workers in a rubber manufacturing company. Methods : In a cross-sectional study, 265 workers studied. Workers divided to shift workers and day workers, their systolic and diastolic blood pressure (SBP;DBP) were measured by standard method. Then mean systolic and diastolic blood pressure and prevalence of hypertension and pre-hypertension were compared between two groups. Logistic regression analysis was used to evaluate the correlation between hypertension and shift work. Chi square, t-test and logistic regression were used for statistical analysis. Results : There were no statistically significant differences between groups in the variables of age, BMI, employment duration, smoking and other confounding factors (p>0.05). The mean values of SBP and DBP and prevalence of pre-hypertension and hypertension was significantly more in shift workers than day workers (p<0.05). After logistic regression analysis with adjustment of confounding variables, significant correlation between shift work and hypertension was found (p<0.05). Odds ratio for hypertension in shift workers was 2.86. Conclusion : Our results suggested that shift work can be a risk factor for hypertension and pre-hypertension. Therefore more attention should be paid to shift workers by periodic measurement of blood pressure .
Shift work, Blood pressure, Hypertension.
http://rjms.iums.ac.ir/article-1-2024-en.html
http://rjms.iums.ac.ir/article-1-2024-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
Evaluation of the value of urinary calcium to creatinine ratio for predicting pre-eclampsia
15
19
FA
Mansooreh
Vahdat
Tehran University of Medical Sciences
N
Maryam
Kashanian
Tehran University of Medical Sciences
Y
Elaheh
Sariri
Tehran University of Medical Sciences
N
Mehrnoosh
Mehdiniaroodsari
Tehran University of Medical Sciences
N
Background : Pre-eclampsia is one of the most serious complications in pregnancy and is one of the major causes of maternal death during pregnancy. Therefore, its prediction has special importance and many studies have been performed on different materials, which may be useful for its prediction. The purpose of the present study was to evaluate the urine calcium to creatinine ratio for prediction of pre-eclampsia. Methods: A prospective cohort study was performed on 150 pregnant women who were 15-35 years old. A single urine sample was obtained at 20-24 weeks of gestation for measurement of urinary calcium and calcium to creatinine ratio. The women were followed till delivery and this ratio was compared between the women with and without pre-eclampsia. Statistical analysis was performed with t-test, Roc Curve and SPSS version 16. p value ˂ 0.05 was considered as statistically significant. Results: Mean urinary calcium of pre-eclamptic women was significantly lower than normotensive women (179± 35 mg/dl vs 272± 59 mg/dl, p<0.001).Mean calcium to creatinine ratio was significantly lower in pre-eclamptic women (0.07±0.007 vs 0.16± 0.006, p<0.001).The optimal cut off point for calcium to creatinine ratio was calculated 0.071 with a sensitivity of 77% and specificity of 78%. Conclusion: Urinary calcium and calcium to creatinine ratio are lower in pre-eclamptic women and may be used as a screening test for the prediction of pre-eclampsia.
Pre-eclampsia, Calcium, Creatinine, Calcium to creatinine ratio, Pregnancy induced hypertension.
http://rjms.iums.ac.ir/article-1-2025-en.html
http://rjms.iums.ac.ir/article-1-2025-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
Evaluation of the risk factors of ectopic pregnancy and a comparison between two age groups: more and less than 20 years old
20
26
FA
Maryam
Kashanian
Tehran University of Medical Sciences
Y
Hamid Reza
Baradaran
Tehran University of Medical Sciences
N
Seydeh Somayeh
Mousavi
N
Background : Ectopic pregnancy (EP), is one of the most important complications of pregnancy and one of the most important factors of maternal mortality in developing countries. Evaluation of the risk factors might be helpful for patients in order to conduct a better management. The purpose of the present study, was to determine the risk factors of ectopic pregnancy and to compare them between the ago group of more and less than 20 years old. Also, these risk factors were compared between Iranian and Afghans. Methods: The study was conducted as a case- control study. In this evaluation 308 cases of EP (case group), were compared with 616 cases of normal pregnancy in Akbarabadi Teaching Hospital. All ectopic pregnancies have been confirmed by surgery and pathology. The evaluated factors were age, BMI, smoking, history of previous EP, history of STD, consanguinity, blood group and Rh, history of infertility and abortion, pelvic surgery, marital age, contraceptive methods, previous cesarean section, socioeconomic status, and nationality. Statistical analyses were performed using SPSS version 16. Chi- square test and logistic regression were used for analysis. Results: Smoking p<0.001, AOR=5.7 (CI 95%= 2.8-11.6)], previous EP p=0.000, AOR= 11.4 (CI 95%= 3-42.4)], previous STD p<0.001, AOR= 3.2 (CI 95%= 2.1-4.9)], previous use of IUD p<0.001, AOR=4.1 (CI 95%= 2.1-8)], history of infertility p=0.01, AOR= 1.8 (CI 95%= 1.1-3)], previous cesarean delivery p=0.03, AOR= 1.5 (CI 95%=1.1-2.3)}, consanguinity, p=0.002, AOR=2.2 (CI 95%= 1.3-3.6)], were considered as risk factors for EP. Age, BMI, previous abortion, socioeconomic status, blood group and Rh, did not show significant relationship with EP. Conclusion: Smoking, previous EP, history of STD, IUD, infertility, previous cesarean delivery, and consanguinity were, risk factors for EP.
Ectopic pregnancy (EP), Risk factor, Smoking, Genital infection, Sexually transmitted disease (STD), Infertility.
http://rjms.iums.ac.ir/article-1-2026-en.html
http://rjms.iums.ac.ir/article-1-2026-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
Effect of Simvastatin on healing of experimental femoral cortical bone defect in rats
27
35
FA
Daryoush
Mohajeri
, Tabriz Branch, Islamic Azad University
Y
Ghafour
Mousavi
, Tabriz Branch, Islamic Azad University
N
Ali
Rezaie
, Tabriz Branch, Islamic Azad University
N
Armin
Alimohamadi
, Tabriz Branch, Islamic Azad University
N
Background : Rebuilding and renovation of lost bone whether because of physiologic or pathologic factors was one of the surgeons’ motivations from the past. Statins are commonly prescribed cholesterol-lowering drugs however, it has recently been shown that they also have the beneficial side effect of enhancing bone matrix formation. As a result, this study evaluates the possible osteogenic effect of Simvastatin on the experimental femoral defect in rats. Methods: This experimental study was conducted on 30 male SD rats. Animals were divided randomly into 3 groups (control and experimental). After induction of general anesthesia, a 2mm hole was made using a dental bit in the width of the femur reaching the medullary channel. After surgery, the control group received orally physiological serum daily and experimental groups 1 and 2 respectively received daily 10 and 20 mg/kg/PO of Simvastatin. Histopathological and histomorphometrical studies for evaluation of bone healing were carried out in experimental rats, which were euthanized after 45 days of the experiment using hematoxylin-eosin (H;E) staining method. For data analysis ANOVA and Tukey tests along with SPSS version 18 was used. Results: In control group, defect seemed to be filled with woven bone and bone marrow spaces in spite of a poor osteogenic activity. In experiment groups, young bone trabeculae had increased in number and were more organized. Histomorphometric results observed that Simvastatin has significant effect on bone healing in experimental groups 2 and 3 than control group, but no significant effect was observed between groups that received low and high dosage of simvastatin. Conclusion: The results of this study show that Simvastatin could stimulate osteogenesis in rats.
Simvastatin, Bone healing, Rat, Histopathology, Histomorphometry.
http://rjms.iums.ac.ir/article-1-2027-en.html
http://rjms.iums.ac.ir/article-1-2027-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
18
91
2012
1
1
Comparison of p53 expression between occupationally exposed to ionizing radiation and control group
36
43
FA
Shahla
Mohammadi
Nuclear Science Research School, Nuclear Science & Technology Research Institute
Y
Mohammad Reza
Gharaati
Tarbiat Modares University
N
Kobra
Ezaki Khan Alang
Qazvin University of Medical Sciences
N
Rasa
Rajaie
Nuclear Science Research School, Nuclear Science & Technology Research Institute
N
Background : Various stresses such as ionizing radiation can increase cellular damage, especially to nuclear DNA. To protect cellular damages, normal regulatory genes (such as Tp53 tumor suppressor) become activated. Accordingly, in this study, the p53 gene and its expression among employees occupationally exposed to low doses of ionizing radiation were compared with a selected control group. Methods : Using an ELISA kit, the amount of p53 protein in the blood serum of case and control groups was measured. Statistical analysis was performed using student t-test procedure. As a case group, 42 healthy individuals (with a mean age of 37.8 ± 1.3 years) occupationally dealing with different kind of radiation sources in Atomic Energy Organization of Iran were chosen. As a control group, 16 healthy unexposed volunteers (with a mean age of 34.5 ± 2.0 years) who were matched for age, sex and smoking habits were selected. A 2 ml aliquot of heparinized peripheral blood was collected from each case. Results : The results of this research indicate the higher levels of p53 expression in occupationally radiation group. Moreover, the work history or smoking had no effects on p53 expression. Conclusion : Although the absorbed doses were below the permissible limits, this study confirms the role of low-level chronic exposure in increasing p53 expression among occupationally radiation workers. These results confirm that monitoring of radiation workers should not only be solely based on physical dosimetry, but also on the biological indicators, which have the advantage of measuring the individual radiation damage.
Protein P53 expression, Ionizing radiation, Cell damage.
http://rjms.iums.ac.ir/article-1-2028-en.html
http://rjms.iums.ac.ir/article-1-2028-en.pdf