Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Incidence of HER 2 membranous expressions in skin basal cell carcinoma in comparison with adjacent normal skin by immunohistochemical method
1
7
FA
Soheila
Nasiri
Shahid Beheshti University of Medical Sciences
N
Nasrin
Shayanfar
Shahid Beheshti University of Medical Sciences
Y
Zahra
Asadi Kani
Shahid Beheshti University of Medical Sciences
N
Shima
Younespour
Tehran University of Medical Sciences
N
Background: Basal
Cell Carcinoma (BCC) is the most common skin cancer. Early diagnosis is usually
associated with complete eradication however some subtypes especially
infiltrative types are associated with deep invasion, multiple recurrences and
wide tissue destruction. Thus, any factor contributing to its development or
help in diagnosis is appreciated. The aim of the present study is evaluation
and comparison of the membranous expression of HER2 protein in normal skin and
cutaneous BCC. Methods: In this cross
sectional study 80 cases of BCC including at least 2 millimeter of surrounding
normal skin were selected and analyzed. Immunohistochemical method is used for
evaluation of membranous expression of HER2 protein in BCC compared to normal
skin. Results: Of 80 cases studied, 34 (42.5%) were
female and 46 (57.5%) were male. Membranous staining was found in 44 (55%) of
normal surrounding skin and 6 (7.5%) of BCC cases. The increased membranous
expression of HER2 in surrounding normal skin compared to BCC was statistically
significant (McNemar test, p< 0.0001). SPSS software was used for
statistical analysis of data. Conclusions: Above findings
suggest that HER2 protein could be a factor in developing of BCC and can be
used as a negative marker in diagnosis of BCC.
Basal cell carcinoma, HER2, Membranous expression, Immunohistochemistry
http://rjms.iums.ac.ir/article-1-2920-en.html
http://rjms.iums.ac.ir/article-1-2920-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Development and validation of the inter-professional collaborator communication skill core competencies
8
16
FA
Seyedeh Batool
Amini
Iran University of Medical Sciences
N
Fatemeh
Keshmiri
Tehran University of Medical Sciences
Y
Kamran
Soltani Arabshahi
Iran University of Medical Sciences
N
Mandana
Shirazi
Tehran University of Medical Sciences
N
Background: Development
of a core competency of inter-professional education is key step in the
implementation of inter professional education and team-based care. The purpose
of this research was to develop a validated set of inter professional
collaborator communication skill core competencies compatible with the Iranian
culture. Methods: This study was
qualitative, and conducted in two phases. In the first phase, a 28 item
framework of the inter-professional collaborator communication skill core
competencies set was developed and the Delphi round of experts was undertaken
to validate these competencies. In the second phase, the validated competencies
were evaluated for clarity and utility in medical science curriculum. Results: The finding of the Delphi round led to
the 24 item framework in 4 core themes of inter professional collaborative
communication skill competency. In the second phase, mean of utility competency
themes showed structured communication (4.77±0.22), communication strategies (4.63±0.24), communication with patient and family (4.63±0.20), and communication with colleagues (4.52±0.32). Overall 17 communication competencies had an average
score greater than 4.5. Conclusions: Development of
inter-professional communication competency is the essential step in order to
fulfill inter-professional collaboration and patient safety. So, it is necessary to be considered in health
care curriculum.
Inter professional education, Communication skill, Communication competency, Inter-professional skill
http://rjms.iums.ac.ir/article-1-2921-en.html
http://rjms.iums.ac.ir/article-1-2921-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Effects of whey protein concentrate consumption compared with isolated soy protein on metabolic indices, inflammatory and oxidative stress factors in healthy overweight and obese men
17
30
FA
Atefeh
Tahavorgar
Tehran University of Medical Sciences
N
Mohammadreza
Vafa
Iran University of Medical Sciences and Health Services
Y
Farzad
Shidfar
Iran University of Medical Sciences and Health Services
N
Mahmood Reza
Gohari
Iran University of Medical Sciences and Health Services
N
Iraj
Heydari
Iran University of Medical Sciences and Health Services
N
Background: In
this study, the effects of consumption of Whey Protein Concentrate (WPC) were
compared with Isolated Soy Protein (ISP) on metabolic, inflammatory and
oxidative stress factors in healthy overweight and obese men. Methods: In this double
- blind randomized clinical trial, 45 healthy overweight and obese men drank
either 65 gr WPC or 60 gr ISP in 500 ml water 30 min before lunch. Fasting
blood samples were analyzed before and after the study, Systolic Blood Pressure
(SBP) and Diastolic Blood Pressure (DBP) were investigated before and after the study and
every two weeks. Results: At the end, there was a significant
difference between the groups for SBP (p<0.02), DBP (p=0.001), Apo
lipoprotein A-I (apo A-I), Apo B, Malondialdehyde – MDA (p<0.001), (Low
Density Lipoprotein -LDL) (p=0.015), (High Density Lipoprotein – HDL) (p=
0.017), (Highsensitive C- reactive Proetein – hs – CRP) (p=0.002). At week 12,
the difference between the groups was nonsignificant for (Total Cholesterol –
TC) (p=0.22), (Triglyceride – TG) and (Very Low – Density Lipoprotein – VLDL)
(p=0.19) and (Fasting Blood Sugar - FBS) (p=0.44). In WPC group, the decrease
of FBS, SBP, DBP, MDA, apo B, VLDL, TG, LDL (p<0.001) and TC and hs-CRP (p=
0.001) was significant. Increase of HDL and apo A-I was respectively
(p<0.001) and (p=0.001) significant. After 12 weeks in ISP there was a
significant decrease for DBP (p=0.001) and other variables did not differ
significantly. Conclusions: Consumption of
65 grams of WPC and 60 grams of ISP before meal during 12 weeks can decrease
CHD risk factors in healthy over weight and obese men and this is more
effective for WPC.
Whey protein concentrate, Isolated soy protein, Metabolic indices, Inflammation, Oxidative stress
http://rjms.iums.ac.ir/article-1-2922-en.html
http://rjms.iums.ac.ir/article-1-2922-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Artificial neural network for risk assessment of neonatal movement disorders
31
38
FA
Farin
Soleimani
University of Social Welfare and Rehabilitation Sciences
N
Robab
Teymouri
University of Social Welfare and Rehabilitation Sciences
N
Sahel
Hemati
University of Social Welfare and Rehabilitation Sciences
N
Akbar
Biglarian
University of Social Welfare and Rehabilitation Sciences
Y
Background: Prediction
of developmental disorders in infancy is very important. This study aimed to
predict movement disorders of children using Artificial Neural Network (ANN)
model. Methods: This was a
retrospective study, in which 600 infants with normal and 120 infants with abnormal
neurologic examination were evaluated. For analysis, the data divided the study
group randomly into two equal parts, training and testing. At first the
learning process was made on training set (360 cases). After the learning
process, testing phase was done with the testing data set (360 cases). All data
analysis was carried out by R 14.1 software. Results: For comparing the accuracy of the
models' prediction, the accuracy classification table was used for the testing
subset. The concordance indexes showed that the ANN model led to more accurate
predictions compared to the LR model (true prediction with or without
developmental disorder was 78.6% vs. 73.9%). The under Receiver Operating
Characteristic (ROC) curves, calculated from testing data, for ANN and LR model
were 0.71 and 0.68, respectively. In addition, specificity and sensitivity of
the ANN model vs. LR model was calculated 88.0% vs. 85.0% and 31.7% vs. 18.3%,
respectively. Conclusions: The ability of
ANN and LR predictions to identify infants without
developmental disorder is similar but the ability of the ANN predictions to
identify infants with developmental disorder is better than LR predictions.
Human development, Infant, Artificial neural network, Logistic regression, Movement disorder
http://rjms.iums.ac.ir/article-1-2923-en.html
http://rjms.iums.ac.ir/article-1-2923-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
The effect of educational intervention based on theory of planned behavior (TPB) for improving method of care of premature infant by mother
39
48
FA
Mahin
Ghasemi
Tehran University of Medical Sciences
N
Tahereh
Dehdari
Iran University of Medical Sciences
Y
Parisa
Mohagheghi
Tehran University of Medical Sciences
N
Mahmood Reza
Gohari
Iran University of Medical Sciences
N
Background: Incorrect belief of mothers in regard to taking for care of their premature
neonates could lead to poor care performance.The purpose of this study was to
evaluate the effect of education based on the theory of planned behavior of
structures on the performance of the mothers, in the care of premature infants
in 2013. Methods: This survey was a quasi-experimental study. Two hospitals affiliated to
Tehran University of Medical Sciences were randomly selected and divided into
control and test groups. Then, 45 mothers were selected by simple sampling method
from each hospital. Instruments for gathering data were designed based on theory of planned behavioral constructs and observational
checklist for assessing function of mother for care of premature
infants. Educational program was designed according of
pre-test results and performed in the experimental group. Two groups were followed-up to the discharge of
the neonates. Data was analyzed by SPSS statistical software (version 16) and independent sample
t-tests and student’s t test for paired sample. Results: Significant
improvements were observed in the mean score of attitude (p<0.0001),
subjective norms (p=0.002), perceived behavioral control (p<0.0001),
intention (p=0.02) and overall performance of mothers to take care of premature infant
(p=0.001) in the experimental group as compared to the control
group. Conclusions: Implementing educational intervention based on theory of planned behavior
constructs may be an effective strategy for improving the performance of mothers to care of premature neonate.
Prematurity, Neonatal intensive care unit, Education, Theory of planned behavior
http://rjms.iums.ac.ir/article-1-2924-en.html
http://rjms.iums.ac.ir/article-1-2924-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
The relationship between addiction and diabetes with fingerprints
49
57
FA
Saeideh
Yousefzadeh
Shahrood University of Technology
Y
Morteza
Zahedi
Shahrood University of Technology
N
Background: Human
skin more than any other part of the body, is exposed to the risks of diseases
and complications of labor. One of the applications of study on the
relationship between skin and diseases is use of fingerprints in the diagnosis
and the subsequent treatment of it. We analyzed the fingerprint images of two
systematic diseases namely diabetes and addiction. Methods: The first
method has been used in the data analysis was power spectrum. The results
showed that in order to extract the features from fingerprint images other
methods must be found. The combination of textural features extracted from the
wavelet coefficients with the statistical features of wavelet, will make
stronger feature vector. In this thesis, two methods based on statistical
characteristics of wavelet and texture features of images have been used for
analysis of fingerprint images in patients. Results: Wavelet
transform and extracted features from wavelet coefficients act stronger than
the Fourier transform in image analysis. Combination of wavelet and texture
features had the best results. Results of addiction and diabetes test were 73%
and 67% respectively. Conclusions: These results are promising in detecting relationship between fingerprints
with diseases. More research is needed on this topic.
Fingerprint, Diseases, Power spectrum, Wavelet, Texture.
http://rjms.iums.ac.ir/article-1-2925-en.html
http://rjms.iums.ac.ir/article-1-2925-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Model of ulcer peptic patients’ quality of life predictors based on path analysis of the PRECEDE model in Sanandaj
58
69
FA
Haidar
Nadrian
Islamic Azad University, Sanandaj Branch
N
Azar
Tol
Tehran University of Medical Sciences
Y
Haydeh
Hoursan
Islamic Azad University, Sanandaj Branch
N
Arezo
Fallahi
Tarbiat Modarres University
N
Background: Peptic
Ulcer Disease (PUD) has a considerable impact on patients’ quality of life. So,
the aim of this study was application of regression based path analysis for
introduction of the best model of PUD quality of life determinants, using
PRECEDE Model constructs. Methods: This cross
sectional study was performed among 120 outpatient referee with PUD to Beasat
Hospital in the city of Sanandaj in Iran. Study instrument included
questionnaires regarding PRECEDE model constructs used to measure the
variables. Reliability and validity of the instruments were examined and
approved. Significant level was set at 0.05. Results: Study findings showed that health status
had a direct effect on quality of life. Self-management behaviors had an
indirect effect on quality of life and health status through reinforcing
factors. Also, predisposing, reinforcing and enabling factors had an indirect
effect on quality of life through health status. After health status,
reinforcing factors was the second powerful predictor of quality of life in PUD
patients and then predisposing factors was the third one. Conclusions: PRECEDE model can
be used as a conceptual framework for designing and implementing educational
intervention programs to promote quality of life in PUD patients. Reinforcing
factors was found as the most powerful factor in the educational and ecological diagnostic stage
of predictors of quality of life in PUD patients which need to be considered,
carefully, while designing intervention programs.
Quality of life, Peptic ulcer disease, PRECEDE model, Path analysis
http://rjms.iums.ac.ir/article-1-2926-en.html
http://rjms.iums.ac.ir/article-1-2926-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
Application of multilevel model in determining the effective factors in the length of stay among appendectomy patients
70
77
FA
Marzieh
mohamadali Noruzi
Tehran University of Medical Sciences
N
Agha Fatemeh
Hosseni
Iran University of Medical Sciences
N
Mahmood Reza
Gohari
Iran University of Medical Sciences
Y
Background: Because of the limitations concerning health centers and
hospitals in Iran, the length of stays at the hospitals is of high importance.
The purpose of this research is to investigate the factors affecting the length
of stay among appendectomy patients at Social Security Organization hospitals
using a multilevel model. Methods: We presented an
applied-analytical study which investigated the relation between length of stay
among appendectomy patients at Social Security Organization hospitals and
variables namely, age, gender, type of insurance and the inpatient bed count at
hospital. The
information of patients who were hospitalized in hospitals for appendectomy
during the first 6 months of 2009, were gathered from HIS system of the hospitals. The three-level regression statistical method
was used to analyze the data. All analyses were conducted
in SAS 9.1 software. Results: The findings show that the average length of stay among
patients was 2.4 days and gender, age, type of insurance and the number of
inpatient bed count at the hospital had no effect on the length of stay at
hospital. The results also indicated that there is a significant difference
between the lengths of stay in different hospitals but no significant
difference was observed between different provinces. Conclusion: Considering the dependence between the data and using the
multi-level regression model led to concluding the significant difference
between the length of stay in different hospitals.
Multilevel regression, Length of stay, Appendectomy, Inpatient
http://rjms.iums.ac.ir/article-1-2927-en.html
http://rjms.iums.ac.ir/article-1-2927-en.pdf
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
20
115
2014
1
1
The effect of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women
78
88
FA
Samaneh
Farahati
Ferdowsi University of Mashhad
Y
Seyed Reza
Atarzadeh Hosseini
Ferdowsi University of Mashhad
N
Nahid
Bijeh
Ferdowsi University of Mashhad
N
Omid
Mahjoob
Mashhad Mehr Hospital
N
Background: Cardiovascular
disease is one of the main causes of morbidity and mortality in postmenopausal
women. Physiological decrease in estrogen levels and accumulation of
visceral fat and being overweight, increase the risk of cardiovascular
disorders in the menopausal years. The aim of this study was to
determine the effects of aerobic exercising on plasma nitric oxide level and
vessel endothelium function in postmenopausal women. Methods: In
this semi-experimental study, twenty-three healthy postmenopausal women with
the average of age: 54.4±5.56 years were randomly divided into two exercise
group (n= 13) and control (n=10) group. The exercise group performed aerobic
exercise for eight weeks, three sessions per week with 50-70% of maximum heart
rate reserve. The duration of each training session was increased from 30 to 45
minutes gradually. During this period, the control group did not participate in
any regular exercise program. Before and after aerobic
training program, anthropometric measurements, VO2 max, nitric oxide
concentrations and Flow Mediated Dilation (FMD) of all subjects were measured.
Data were analyzed with paired t-student test at a significance level of
p<0.05. Results: Eight weeks of
aerobic exercise, led to a significant reduction in weight and body fat VO2max
(p=0.001), FMD index (p=0.026) and nitric oxide concentration (p=0.003) were
significantly increased after aerobic exercise program. Conclusions: Eight
weeks of aerobic exercise induced increasing in nitric oxide and improving the
vessel endothelium function in postmenopausal women and it can be said that
regular exercise may probably have a preventive effect for the development of
cardiovascular disease in postmenopausal women.
Aerobic exercising, Endothelium function, FMD index, Nitric oxide, Postmenopausal women
http://rjms.iums.ac.ir/article-1-2928-en.html
http://rjms.iums.ac.ir/article-1-2928-en.pdf