@article{ author = {Nasiri, Soheila and Shayanfar, Nasrin and AsadiKani, Zahra and Younespour, Shim}, title = {Incidence of HER 2 membranous expressions in skin basal cell carcinoma in comparison with adjacent normal skin by immunohistochemical method}, abstract ={ Background: Basal Cell Carcinoma (BCC) is the most common skin cancer. Early diagnosis is usually associated with complete eradication however some subtypes especially infiltrative types are associated with deep invasion, multiple recurrences and wide tissue destruction. Thus, any factor contributing to its development or help in diagnosis is appreciated. The aim of the present study is evaluation and comparison of the membranous expression of HER2 protein in normal skin and cutaneous BCC. Methods: In this cross sectional study 80 cases of BCC including at least 2 millimeter of surrounding normal skin were selected and analyzed. Immunohistochemical method is used for evaluation of membranous expression of HER2 protein in BCC compared to normal skin. Results: Of 80 cases studied, 34 (42.5%) were female and 46 (57.5%) were male. Membranous staining was found in 44 (55%) of normal surrounding skin and 6 (7.5%) of BCC cases. The increased membranous expression of HER2 in surrounding normal skin compared to BCC was statistically significant (McNemar test, p< 0.0001). SPSS software was used for statistical analysis of data. Conclusions: Above findings suggest that HER2 protein could be a factor in developing of BCC and can be used as a negative marker in diagnosis of BCC. }, Keywords = {Basal cell carcinoma, HER2, Membranous expression, Immunohistochemistry}, volume = {20}, Number = {115}, pages = {1-7}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2920-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2920-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Amini, Seyedeh Batool and Keshmiri, Fatemeh and SoltaniArabshahi, Kamran and Shirazi, M}, title = {Development and validation of the inter-professional collaborator communication skill core competencies}, abstract ={ Background: Development of a core competency of inter-professional education is key step in the implementation of inter professional education and team-based care. The purpose of this research was to develop a validated set of inter professional collaborator communication skill core competencies compatible with the Iranian culture. Methods: This study was qualitative, and conducted in two phases. In the first phase, a 28 item framework of the inter-professional collaborator communication skill core competencies set was developed and the Delphi round of experts was undertaken to validate these competencies. In the second phase, the validated competencies were evaluated for clarity and utility in medical science curriculum. Results: The finding of the Delphi round led to the 24 item framework in 4 core themes of inter professional collaborative communication skill competency. In the second phase, mean of utility competency themes showed structured communication (4.77±0.22), communication strategies (4.63±0.24), communication with patient and family (4.63±0.20), and communication with colleagues (4.52±0.32). Overall 17 communication competencies had an average score greater than 4.5. Conclusions: Development of inter-professional communication competency is the essential step in order to fulfill inter-professional collaboration and patient safety. So, it is necessary to be considered in health care curriculum. }, Keywords = {Inter professional education, Communication skill, Communication competency, Inter-professional skill}, volume = {20}, Number = {115}, pages = {8-16}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2921-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2921-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Tahavorgar, Atefeh and Vafa, Mohammadreza and Shidfar, Farzad and Gohari, Mahmood Reza and Heydari, Iraj}, title = {Effects of whey protein concentrate consumption compared with isolated soy protein on metabolic indices, inflammatory and oxidative stress factors in healthy overweight and obese men}, abstract ={ Background: In this study, the effects of consumption of Whey Protein Concentrate (WPC) were compared with Isolated Soy Protein (ISP) on metabolic, inflammatory and oxidative stress factors in healthy overweight and obese men. Methods: In this double - blind randomized clinical trial, 45 healthy overweight and obese men drank either 65 gr WPC or 60 gr ISP in 500 ml water 30 min before lunch. Fasting blood samples were analyzed before and after the study, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) were investigated before and after the study and every two weeks. Results: At the end, there was a significant difference between the groups for SBP (p<0.02), DBP (p=0.001), Apo lipoprotein A-I (apo A-I), Apo B, Malondialdehyde – MDA (p<0.001), (Low Density Lipoprotein -LDL) (p=0.015), (High Density Lipoprotein – HDL) (p= 0.017), (Highsensitive C- reactive Proetein – hs – CRP) (p=0.002). At week 12, the difference between the groups was nonsignificant for (Total Cholesterol – TC) (p=0.22), (Triglyceride – TG) and (Very Low – Density Lipoprotein – VLDL) (p=0.19) and (Fasting Blood Sugar - FBS) (p=0.44). In WPC group, the decrease of FBS, SBP, DBP, MDA, apo B, VLDL, TG, LDL (p<0.001) and TC and hs-CRP (p= 0.001) was significant. Increase of HDL and apo A-I was respectively (p<0.001) and (p=0.001) significant. After 12 weeks in ISP there was a significant decrease for DBP (p=0.001) and other variables did not differ significantly. Conclusions: Consumption of 65 grams of WPC and 60 grams of ISP before meal during 12 weeks can decrease CHD risk factors in healthy over weight and obese men and this is more effective for WPC. }, Keywords = { Whey protein concentrate, Isolated soy protein, Metabolic indices, Inflammation, Oxidative stress}, volume = {20}, Number = {115}, pages = {17-30}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2922-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2922-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Soleimani, Farin and Teymouri, Robab and Hemati, Sahel and Biglarian, Akbar}, title = {Artificial neural network for risk assessment of neonatal movement disorders}, abstract ={ Background: Prediction of developmental disorders in infancy is very important. This study aimed to predict movement disorders of children using Artificial Neural Network (ANN) model. Methods: This was a retrospective study, in which 600 infants with normal and 120 infants with abnormal neurologic examination were evaluated. For analysis, the data divided the study group randomly into two equal parts, training and testing. At first the learning process was made on training set (360 cases). After the learning process, testing phase was done with the testing data set (360 cases). All data analysis was carried out by R 14.1 software. Results: For comparing the accuracy of the models' prediction, the accuracy classification table was used for the testing subset. The concordance indexes showed that the ANN model led to more accurate predictions compared to the LR model (true prediction with or without developmental disorder was 78.6% vs. 73.9%). The under Receiver Operating Characteristic (ROC) curves, calculated from testing data, for ANN and LR model were 0.71 and 0.68, respectively. In addition, specificity and sensitivity of the ANN model vs. LR model was calculated 88.0% vs. 85.0% and 31.7% vs. 18.3%, respectively. Conclusions: The ability of ANN and LR predictions to identify infants without developmental disorder is similar but the ability of the ANN predictions to identify infants with developmental disorder is better than LR predictions. }, Keywords = {Human development, Infant, Artificial neural network, Logistic regression, Movement disorder}, volume = {20}, Number = {115}, pages = {31-38}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2923-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2923-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Ghasemi, Mahin and Dehdari, Tahereh and Mohagheghi, Parisa and Gohari, Mahmood Rez}, title = {The effect of educational intervention based on theory of planned behavior (TPB) for improving method of care of premature infant by mother}, abstract ={ Background: Incorrect belief of mothers in regard to taking for care of their premature neonates could lead to poor care performance.The purpose of this study was to evaluate the effect of education based on the theory of planned behavior of structures on the performance of the mothers, in the care of premature infants in 2013. Methods: This survey was a quasi-experimental study. Two hospitals affiliated to Tehran University of Medical Sciences were randomly selected and divided into control and test groups. Then, 45 mothers were selected by simple sampling method from each hospital. Instruments for gathering data were designed based on theory of planned behavioral constructs and observational checklist for assessing function of mother for care of premature infants. Educational program was designed according of pre-test results and performed in the experimental group. Two groups were followed-up to the discharge of the neonates. Data was analyzed by SPSS statistical software (version 16) and independent sample t-tests and student’s t test for paired sample. Results: Significant improvements were observed in the mean score of attitude (p<0.0001), subjective norms (p=0.002), perceived behavioral control (p<0.0001), intention (p=0.02) and overall performance of mothers to take care of premature infant (p=0.001) in the experimental group as compared to the control group. Conclusions: Implementing educational intervention based on theory of planned behavior constructs may be an effective strategy for improving the performance of mothers to care of premature neonate. }, Keywords = {Prematurity, Neonatal intensive care unit, Education, Theory of planned behavior}, volume = {20}, Number = {115}, pages = {39-48}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2924-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2924-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Yousefzadeh, Saeideh and Zahedi, Mortez}, title = {The relationship between addiction and diabetes with fingerprints}, abstract ={ Background: Human skin more than any other part of the body, is exposed to the risks of diseases and complications of labor. One of the applications of study on the relationship between skin and diseases is use of fingerprints in the diagnosis and the subsequent treatment of it. We analyzed the fingerprint images of two systematic diseases namely diabetes and addiction. Methods: The first method has been used in the data analysis was power spectrum. The results showed that in order to extract the features from fingerprint images other methods must be found. The combination of textural features extracted from the wavelet coefficients with the statistical features of wavelet, will make stronger feature vector. In this thesis, two methods based on statistical characteristics of wavelet and texture features of images have been used for analysis of fingerprint images in patients. Results: Wavelet transform and extracted features from wavelet coefficients act stronger than the Fourier transform in image analysis. Combination of wavelet and texture features had the best results. Results of addiction and diabetes test were 73% and 67% respectively. Conclusions: These results are promising in detecting relationship between fingerprints with diseases. More research is needed on this topic. }, Keywords = {Fingerprint, Diseases, Power spectrum, Wavelet, Texture.}, volume = {20}, Number = {115}, pages = {49-57}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2925-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2925-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Nadrian, Haidar and Tol, Azar and Hoursan, Haydeh and Fallahi, Arezo}, title = {Model of ulcer peptic patients’ quality of life predictors based on path analysis of the PRECEDE model in Sanandaj}, abstract ={ Background: Peptic Ulcer Disease (PUD) has a considerable impact on patients’ quality of life. So, the aim of this study was application of regression based path analysis for introduction of the best model of PUD quality of life determinants, using PRECEDE Model constructs. Methods: This cross sectional study was performed among 120 outpatient referee with PUD to Beasat Hospital in the city of Sanandaj in Iran. Study instrument included questionnaires regarding PRECEDE model constructs used to measure the variables. Reliability and validity of the instruments were examined and approved. Significant level was set at 0.05. Results: Study findings showed that health status had a direct effect on quality of life. Self-management behaviors had an indirect effect on quality of life and health status through reinforcing factors. Also, predisposing, reinforcing and enabling factors had an indirect effect on quality of life through health status. After health status, reinforcing factors was the second powerful predictor of quality of life in PUD patients and then predisposing factors was the third one. Conclusions: PRECEDE model can be used as a conceptual framework for designing and implementing educational intervention programs to promote quality of life in PUD patients. Reinforcing factors was found as the most powerful factor in the educational and ecological diagnostic stage of predictors of quality of life in PUD patients which need to be considered, carefully, while designing intervention programs. }, Keywords = {Quality of life, Peptic ulcer disease, PRECEDE model, Path analysis}, volume = {20}, Number = {115}, pages = {58-69}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2926-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2926-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {mohamadaliNoruzi, Marzieh and Hosseni, Agha Fatemeh and Gohari, Mahmood Rez}, title = {Application of multilevel model in determining the effective factors in the length of stay among appendectomy patients}, abstract ={ Background: Because of the limitations concerning health centers and hospitals in Iran, the length of stays at the hospitals is of high importance. The purpose of this research is to investigate the factors affecting the length of stay among appendectomy patients at Social Security Organization hospitals using a multilevel model. Methods: We presented an applied-analytical study which investigated the relation between length of stay among appendectomy patients at Social Security Organization hospitals and variables namely, age, gender, type of insurance and the inpatient bed count at hospital. The information of patients who were hospitalized in hospitals for appendectomy during the first 6 months of 2009, were gathered from HIS system of the hospitals. The three-level regression statistical method was used to analyze the data. All analyses were conducted in SAS 9.1 software. Results: The findings show that the average length of stay among patients was 2.4 days and gender, age, type of insurance and the number of inpatient bed count at the hospital had no effect on the length of stay at hospital. The results also indicated that there is a significant difference between the lengths of stay in different hospitals but no significant difference was observed between different provinces. Conclusion: Considering the dependence between the data and using the multi-level regression model led to concluding the significant difference between the length of stay in different hospitals. }, Keywords = {Multilevel regression, Length of stay, Appendectomy, Inpatient}, volume = {20}, Number = {115}, pages = {70-77}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2927-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2927-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} } @article{ author = {Farahati, Samaneh and AtarzadehHosseini, Seyed Reza and Bijeh, Nahid and Mahjoob, Omi}, title = {The effect of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women}, abstract ={ Background: Cardiovascular disease is one of the main causes of morbidity and mortality in postmenopausal women. Physiological decrease in estrogen levels and accumulation of visceral fat and being overweight, increase the risk of cardiovascular disorders in the menopausal years. The aim of this study was to determine the effects of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women. Methods: In this semi-experimental study, twenty-three healthy postmenopausal women with the average of age: 54.4±5.56 years were randomly divided into two exercise group (n= 13) and control (n=10) group. The exercise group performed aerobic exercise for eight weeks, three sessions per week with 50-70% of maximum heart rate reserve. The duration of each training session was increased from 30 to 45 minutes gradually. During this period, the control group did not participate in any regular exercise program. Before and after aerobic training program, anthropometric measurements, VO2 max, nitric oxide concentrations and Flow Mediated Dilation (FMD) of all subjects were measured. Data were analyzed with paired t-student test at a significance level of p<0.05. Results: Eight weeks of aerobic exercise, led to a significant reduction in weight and body fat VO2max (p=0.001), FMD index (p=0.026) and nitric oxide concentration (p=0.003) were significantly increased after aerobic exercise program. Conclusions: Eight weeks of aerobic exercise induced increasing in nitric oxide and improving the vessel endothelium function in postmenopausal women and it can be said that regular exercise may probably have a preventive effect for the development of cardiovascular disease in postmenopausal women. }, Keywords = {Aerobic exercising, Endothelium function, FMD index, Nitric oxide, Postmenopausal women}, volume = {20}, Number = {115}, pages = {78-88}, publisher = {Iran University of Medical Sciences}, url = {http://rjms.iums.ac.ir/article-1-2928-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2928-en.pdf}, journal = {Razi Journal of Medical Sciences}, issn = {2228-7043}, eissn = {2228-7051}, year = {2014} }