per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
1
11
article
The effect of aerobic exercise on levels of HS-CRP, insulin resistance index and lipid profile in untrained middle-aged women
Nahid Bijeh
bijeh@ferdowsi.um.ac.ir
1
Keyvan Hejazi
keyvanhejazi@gmail.com
2
Ferdowsi University of Mashhad
Ferdowsi University of Mashhad
Background: Cardiovascular disease is becoming the major cause of human morbidity and mortality in most countries of the world.These diseases are now among the top three causes of death and disability in human around the world. The aim of this study was to determin the effect of aerobic exercise on levels of HS-CRP, insulin resistance index and lipid profile in untrained middle-aged women.
Methods: In this semi experimental study, nineteen healthy female middle-aged were selected by convenience sampling method and randomly divided into two experimental (11 people) and control (8 people) groups. The exercise protocol included aerobic exercise training that lasted for 6 months (3 days/week), 60 minutes with intensity of 55-65 percent of heart rate reserve. Blood samples were collected to measure lipid profiles, insulin resistance index and HS-CRP before and after of the 6 months aerobic exercise. For comparison of means within and between means groups Paired and Independent t-test was used respectively and the results were determined within the significance level of P≤0.05.
Results: The levels of HDL-C, TG, FBS and insulin in subjects were not changed significantly. The levels of HS-CRP and insulin resistance also reduced but it was not significant (p>0.05). Accordingly, the levels of TC, LDL-Cand TC/HDL-C during this period increased significantly.
Conclusion: To reduce the risk factors forcardiovascular diseases, in order to controland prevent heart diseases,isof great importance, therefore,any aerobic exercisecan reducetherisk factors and be helpful.
http://rjms.iums.ac.ir/article-1-2468-en.pdf
High Sensitivity C - reactive protein
Insulin resistance index
Lipid profiles
Untrained middle-aged women
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
12
18
article
investigation and comparison of Information processing speed between three different subtypes of multiple sclerosis and healthy control subjects
reza hemati
Rezahemmati@outlook.com
1
nava yadolahpour
nava.pt84@yahoo.com
2
enayatolah bakhshi
e.bakhshi@uswr.ac.ir
3
iraj abdolahi
irajabdollahi@hotmail.com
4
University of Social Welfare and Rehabilitation, Tehran, Iran.
Jundishapour University of Medical Sciences, Ahvaz, Iran.
University of Social Welfare and Rehabilitation, Tehran, Iran.
University of Social Welfare and Rehabilitation, Tehran, Iran
Background: Multiple Sclerosis (MS), as one of the most common neurological diseases of the central nervous system, is associated with various cognitive impairments. The purpose of this study was the investigation and comparison of the information processing speed between various clinical subtypes of multiple sclerosis and compared to healthy individuals.
Methods: In this cross-sectional study, 22 healthy volunteers, 21 relapsing-remitting MS, 8 primary progressive MS, and 21 secondary progressive MS patients were matched by age, gender and level of education with each other and the information processing speed was investigated using designed Deary-Liewald software and were analyzed and compared using analysis of variance (ANOVA).
Results: The results of ANOVA revealed that data processing speed was different at least between two groups (p<0.05). Paired comparison of groups with Tukay HSD post hoc test revealed that there was no significant difference between healthy subjects with relapsing-remitting (p>0.05). Healthy subjects compared to primary progressive and secondary progressive have significant difference (p>0.05). There was no significant difference between other subtypes of multiple sclerosis (p>0.05).
Conclusion: The progressive MS subtypes, specially the secondary progressive subtype, have slower movement information processing compared to healthy subjects and other MS subtypes, and in the comparison of MS subtypes there was no significant difference.
http://rjms.iums.ac.ir/article-1-3761-en.pdf
multiple sclerosis
information processing speed
reaction time
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
19
25
article
Evaluating the Performance of the Exponentially Weighted Moving Average to detection of influenza outbreaks in Iran
Manoochehr Solgi
m.solgi2121@yahoo.com
1
Manoochehr Karami
man.karami@yahoo.com
2
Jalal Poorolajal
pooorolajal@umsha.ac.ir
3
Seyed Hadi Hosseini
seyyedhh79@gmail.com
4
Hamadan University of Medical Sciences, Hamadan, Iran
Hamadan University of Medical Sciences, Hamadan, Iran
Hamadan University of Medical Sciences, Hamadan, Iran
Hamadan University of Medical Sciences, Hamadan, Iran
Background: Timely response to influenza outbreaks using Influenza like illness (ILI) data is one of the most important priorities for public health authorities. The aim of this study was to evaluate the performance of the Exponentially Weighted Moving Average (EWMA) for timely detection of influenza outbreaks in Iran using simulated approaches from January 2010 to December 2015.
Methods: Simulated influenza outbreaks were generated using ILI data as syndromic data of influenza according to potentially occurred outbreaks including uniform, linear and exponential distribution of corresponding epidemic curves. The performance of variety λ (smoothing parameter) values of EWMA was measured using sensitivity, specificity, false alarm rate, likelihood ratios and area under the receiver operating characteristics (ROC) curve.
Results: The overall sensitivity of EWMA in detection of uniformly distributed influenza outbreaks was 70% (95%CI: 30, 80). The corresponding values for linear and exponential distribution of epidemic curves were 84% (95%CI: 75, 92) and 51% (95%CI: 40, 62). EWMA with λ=0.9 had the best performance for timely detection of influenza outbreaks in comparison to other smoothing parameters.
Conclusion: Findings revealed that EWMA works well in detection of influenza outbreaks. However, national influenza surveillance systems need to use different outbreak detection methods for detecting aberrations in influenza-like illnesses activity.
http://rjms.iums.ac.ir/article-1-4785-en.pdf
Influenza
Exponentially Weighted Moving Average
Outbreak
Iran
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
26
35
article
The effect of military training and lifestyle on the Anthropometric status of Iranian youth
Jamal Rahmani
mojtaba1717@yahoo.com
1
Mir Saeid Yekaninejad
mojtaba.rah91@gmail.com
2
Ahmadreza Dorosty Motlagh
dorostim42@yahoo.com
3
Tehran University of Medical Sciences, Tehran, Iran
Tehran University of Medical Sciences, Tehran, Iran
Tehran University of Medical Sciences, Tehran, Iran
Background: Body Mass index (BMI) and waist circumference are the predictors of chronic diseases. Anthropometric measurements help to remain healthy. This study aimed at examining the effect of lifestyle on anthropometric changes over the course.
Methods: In this study, 246 individuals were selected according to criteria. Cluster sampling was done in the military barracks. After obtaining consent, anthropometric indices, demographic and food recall were measured and followed to end course. Relationship between lifestyle and anthropometry was determined by linear regression. A p- value less than 0.05 was considered significant.
Results: Mean BMI before the start of training 23.9+3.8 and waist 88.7+0.6 cm and after the period decreased to 22.3+7.0 and 87.9+3.9 cm respectively. Dietary diversity and physical activity before entering to course had statistically significant effect on anthropometric changes during the military period.
Conclusion: BMI and waist circumference decreased during the military training. Dietary diversity and high physical activity prevent anthropometric changes. Further studies of these relationships make it clearer.
http://rjms.iums.ac.ir/article-1-4508-en.pdf
Body mass index
waist circumference
army
dietary diversity
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
36
47
article
Chronic Hepatites B and Pregnancy: Challenges and opportunities (Review Article)
Azita Fathnezhad Kazemi
afnkazemi@gmial.com
1
Nasibeh Sharifi
nasibe.sharifi@yahoo.com
2
Armin Aslani
aslard2014@gmail.com>
3
Zohreh Keshavarz
a_kazemi@sbmu.ac.ir
4
Islamic Azad University, Tabriz, Iran
Ilam University of Medical Sciences, Ilam, Iran
Islamic Azad University, Tabriz branch, Tabriz, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Hepatitis B is one of the major health problems in the world, especially in developing countries. About 5 percents of women are carriers of this disease, mother to child transmission also known as” vertical transmission” is the most common mode of transmission. The aim of this study is to provide information for health workers and new knowledge by focusing on the different issues concerning chronic hepatitis B in pregnant women and those who are considering getting pregnant
Methods: Data of this study were collected using various studies from following databases: Google Scholar, PubMed (Medline) and Scopus also World Health Organization (WHO) and the Center for Disease Control and Prevention (CDC) websites. A comprehensive search was conducted by the keywords of hepatitis B and pregnancy and hepatitis B. Searching strategies were done by advanced search capability. All examined articles were published during the last 5 years (2010-15) which were in English and had full text. After the initial search and the reference list, a total of 43 articles were included in this study.
Results: This article deals with the different aspects of chronic hepatitis in pregnancy. To begin with, hepatitis has no effect on fertility, but in case of using IVF, lower fertility rates have been reported in infected infertile patients. Second: screening and preventive measures (such as monoprophylaxis and new methods of drug and immunoglobulin use) to prevent vertical transmission in pregnant women were considered. Third; antiretroviral therapy in pregnant women should be based on the therapeutic protocol. Finally; cesarean delivery is not advised in infected women unless it is performed before the beginning of labor. There might be the need for further investigation and infected women should be encouraged to breastfeed their babies.
Conclusion: Pregnancy is a perfect opportunity to stop the transmission of hepatitis B, especially in developing countries. Within this context, we can develop strategies as an important step to reduce the burden of disease, still further investigations yet to be done.
http://rjms.iums.ac.ir/article-1-4259-en.pdf
hepatitis B
pregnancy
vertical transmission
anti-virus
prevention
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
48
57
article
Update of Vaginitis for obstetricians : A Review
Soheila Aminimoghaddam
Dr_aminimoghaddam@yahoo.com
1
Saeedeh Sadat Batayee
saeedehbatayee@gmail.com
2
Andisheh Maghsoudnia
A.maghsoudnia@gmail.com
3
Marzieh Mohammadi
4
Iran University of Medical Sciences, Tehran, Iran
Tehran, Iran
Tarbiat Modares University of Tehran, Tehran, Iran.
Iran University of Medical Sciences, Tehran Iran.
Background: Vaginitis is one of the most common reasons for patients seeking a physician’s care. Cervicitis is cervical inflammation due to infectious or noninfectious pathogens and can be acute or chronic. Some of these pathogens are transmitted to sexual partner or cause morbidity in gynecological surgery. Furthermore, bacterial vaginosis is a cause of morbidity in pregnancy. This study reviews screening and management of common vaginitis (bacterial vaginosis, candidiasis, trichomonas and desquamative inflammatory vaginitis).
Methods: With search in academic books in obstetrics and gynecology and infectious disorder and search engines, new results about vaginitis is presented.
Results: Vaginitis can be cured spontaneously in candidiasis but in some women bacterial vaginosis is a cause of morbidity in pregnancy and gynecological surgery.
Conclusion: By understanding the pathophysiology of these diseases and having an effective approach to their diagnosis, physicians can institute appropriate therapy to treat these conditions and reduce long-term sequelae.
http://rjms.iums.ac.ir/article-1-4592-en.pdf
Vaginitis
Bacterial vaginosis
Candida
Trichomonas
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
58
62
article
hypertension and nephrotic syndrome, a rare case
Azar NikAvar
anickavar@yahoo.com
1
Iran University of Medical Sciences, Tehran, Iran.
Nephrotic syndrome is a rare manifestation of renal artery stenosis, presented mainly in adulthood. This is the report of a 4 months old boy admitted for hypertension and nephrotic syndrome. Left renal artery stenosis and renal hypoplasia were documented by laboratory and imaging studies. Proteinuria improved with medical treatment, with no need to surgical repair. Blood pressure remained normal during follow up, with no need to further medical treatment.
http://rjms.iums.ac.ir/article-1-4755-en.pdf
hypertension
nephrotic syndrome
renovascular hypertension
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
63
69
article
Update in Systemic Lupus Erythematosus
Nahid Kianmehr
kianmehrnahid@gmail.com
1
Iran University of Medical Sciences, Tehran, Iran
Systemic Lupus Erythematosus (SLE) is a chronic, life threatening systemic disorder that may affect multiple organs in the body. Dysfunction of the immune system, leading to over production of antibodies and immune complexes cause wide arrays of clinical feature. The classification criteria of SLE were updated in 2012. Treatment of SLE is individualized based on severity and extent of organ involvement. Nowadays, treat to target approach makes much more medications available and holds much more promise on the management of SLE.
http://rjms.iums.ac.ir/article-1-4842-en.pdf
Systemic Lupus Erythematosus
Treat to target
Antibodies
Biologic medication
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
70
79
article
Effect of Iron oxide nanoparticles and magnetic field on neurogenesis and Nestin gene expression after ischemic reperfusion in rat
Ayshin bagheri
ayshin_bagheri@yahoo.com
1
Zeinab Khazaei Koohpar
z.khazaei@gmail.com
2
Mojtaba Falahati
falahati@ibb.ut.ac.ir
3
Islamic Azad University, Tonekabon, Iran.
Islamic Azad University, Tonekabon, Iran.
Islamic Azad University, Tehran, Iran.
Background: Ischemic stroke is a common cause of adult disability and death worldwide that leads to damage in neuronal networks and neurovascular units and ceasation of brain functions. In this study the effect of iron oxide nanoparticles and magnetic field on neurogenesis after ischemic reperfusion (IR) in rat model was evaluated.
Methods: In this experimental study 50 male Wistar rats weighing 220-250 g were randomly divided into five groups of 10 rats each: including control, sham (ischemic reperfusion model), IR + iron oxide nanoparticles (10mg/kg), IR+magnetic field (1 Tesla, 20 min in 4 days), and IR + iron oxide nanoparticles and magnetic field groups. Injections were performed intraperitoneally. Neurogenesis was evaluated in hippocampus of 5 groups after 4 days by H&E staining method. Nestin gene expression was quantitatively investigated in 5 groups by Real-time PCR.
Results: In this study it was revealed that the iron oxide nanoparticles as well as the magnetic field increase the neurogenesis rate after ischemic reperfusion during 4 days (p<0.05). The expression of Nestin gene increased in iron oxide nanoparticles treated group and the magnetic field exposed group significantly (p<0.05) as compared to ischemic reperfusion model. However, their combined treatment did not show a significant difference compared with the sham group within 4 days.
Conclusion: Our result suggests iron oxide nanoparticles as well as magnetic field separately can be two effective methods in ischemia therapy.
http://rjms.iums.ac.ir/article-1-4881-en.pdf
iron oxide nanoparticles
ischemic reperfusion
magnetic field
Nestin
Real-time PCR
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
80
91
article
Evaluation and comparison of antibody titers against single recombinant proteins, mixtures and chimer CTXB, TCPA and CTXB-TCPA
Milad Amerian
m.amerianbio@gmail.com
1
Shahram Nazarian
nazarian56@gmail.com
2
Imam Hossain University, Tehran, Iran.
Imam Hossain University, Tehran, Iran.
Background: Cholera as diarrheal illness is one of the most important causes of death and people's disability in different societies. Colonization factor pili (tcpA) and cholera toxin are the most important factors in the pathogenesis of Vibrio Cholera. B subunit of cholera toxin (ctxB) and tcpA have the ability to induce immune responses. The aims of this study was production of CTXB, TCPA, CTXB-TCPA recombinant protein and evaluation of antibody titers against separately, cocktail and chimeric protein in mice.
Methods: In this research study, ctxB ،tcpA and ctxB-tcpA genes were cloned in pET28a and pET32a vectors. Recombinant plasmids was transformed to Escherichia coli (E.coli) BL21 DE3 and expression was induced with IPTG. The protein expression were evaluated by SDS-PAGE and Western Blotting analysis. The recombinant proteins were purified using Ni–NTA affinity chromatography. Mice immunization were done subcutaneously or intraperitoneally. Antibody titer was determined by ELISA in immunized mice sera.
Results: SDS PAGE and western blotting confirmed expression and purification of recombinant proteins. The yield of purified CTXB, TCPA, CTXB-TCPA proteins was 15/570, 11/533 and 33/100 mg/L, respectively. ELISA results showed satisfactory immunization of mice.
There was no significant difference in antibody titers against CTXB-TCPA protein and CTXB, TCPA cocktail. Also, no significant difference was observed in titers between subcutaneously or intraperitoneal injection.
Conclusion: The low differences in the antibody titer may be related to the longevity of memory cells and also their injection method. Due to the advantages of chimeric proteins, CTXB-TCPA protein could be a good alternative instead of protein cocktail to stimulate the immune system.
http://rjms.iums.ac.ir/article-1-4920-en.pdf
Vibrio cholera
ctxB
tcpA
Chimeric recombinant
Antibody titer
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2018-01
24
163
92
104
article
Nutritional assessment in ICU patients with enteral feeding in Amol hospitals
Mostafa Nachvak
smnachvak@hotmail.com
1
Safoura Hedayati
safoorahedayati@yahoo.com
2
Najmeh Hejazi
N20hejazi@yahoo.com
3
Ali Motamedi Motlagh
Alimotamedi72@yahoo.com
4
Abdollah Shafizade
Shafizaded.shafizadeh.a@gmail
5
Marzie Shojaee
Malihe.shojaei@yahoo.com
6
Kermanshah University of Medical Sciences, Kermanshah, Iran.
Kermanshah University of Medical Sciences, Kermanshah, Iran.
Shiraz University of Medical Sciences, Shiraz, Iran.
Babol Islamic Azad University, Babol, Iran.
Islamic Azad University Ayatollah Amoli unit Amol, Emam Reza Hospital, Amol, Iran.
Mazandaran University of Medical Sciences, Amol, Iran.
Background: Appropriate nutritional support has an important role in the treatment of critically ill patients. Malnutrition has a lot of negative effect on the condition of these patients. The purpose of this study was to assess the nutritional status of patients with enteral nutrition in intensive care unit.
Methods: In this descriptive-analytic study, 85 patients were studied during their hospitalization in 4 ICUs of two hospitals in Amol, Iran. The prevalence of malnutrition was evaluated according to Subjective Global Assessment (SGA), APACHE IV score, anthropometric indices and biochemical parameters. Also the amount of nutritional needs was determined and compared with the patient's needs.
Results: The prevalence of malnutrition according to (SGA) was (42.6%) on the admission day and (83.5%) on discharge day that increased significantly (p<0.001). The patient's anthropometric parameter related to nutritional status, decreased significantly on the discharge day as compared with the admission day. Blood creatinine levels (p=0.001) and lymphocyte count (p<0.001) decreased significantly during the hospitalization period. The mean of energy and protein intake were less than requirement, significantly. A negative significant correlation between anthropometric measurements and some biochemical indices with malnutrition on the discharge day was observed (p<0.05).
Conclusion: The prevalence of malnutrition was increased significantly in ICU patients during hospitalization. Handmade gavage solutions did not provide enough energy and protein requirements for the patients. The anthropometric measurements and some biochemical indexes were predictors of malnutrition in this study.
http://rjms.iums.ac.ir/article-1-4882-en.pdf
Nutritional care
Malnutrition
Subjective Glubal Assessment
Enteral nutrition