per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
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article
RNAs in Mature Spermatozoa
Mohammad Hossein Modarressi
1
Maryam Eghbali
2
Tehran University of Medical Sciences
Tehran University of Medical Sciences
The nucleus
of mature sperm contains a complex population of transcripts such as mRNAs and
miRNAs which expressed and accumulated during process of spermatogenesis
however in
spermatozoa, transcription is inert. The spermatozoa do not have cytoplasmic ribosomal
compounds and translation apparatus.
However, spermatozoa can translate cytoplasmic mRNAs de novo, using
mitochondrial polysomes. Important roles of spermatozoa RNAs include chromatin
repackaging, paternal genomic imprintingand gene silencing. Recent information of transferred spermatozoa
RNAs into oocytes during fertilization and RNA-mediated epigenetic effect
contribute extra genomically to early embryonic growth. Furthermore,
regardless of the biological roles of spermatozoal RNA and embryonic growth,
the differences in profile expression of spermatozoa RNAs from fertile and
infertile men, provide potential spermatozoa markers in assessment male
fertility and infertility. In this
review, presence of RNAs in mature sperm, diversity and functions of gene
transcripts in male fertility and embryonic development are discussed.
http://rjms.iums.ac.ir/article-1-2654-en.pdf
Spermatozoa
Coding and non-coding RNAs
Roles of spermatozoa RNAs.
per
Iran University of Medical Sciences
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article
Clinical characteristics and laboratory findings of 274 patients with chronic urticarial and review of literatures
Javad Ghaffari
1
Mohammad Naderi
2
Mohammad Khademloo3
3
Mazandaran University of Medical Sciences
Mazandaran University of Medical Sciences
Mazandaran University of Medical Sciences
Background: Chronic
urticaria is a common skin disorder with incidence of 0.3 to 11.3 percent
people. Up to 20 % of general population affected it in their life span. There is not known etiology in the most cases
of chronic urticarial. The aim of this study was to detect clinical
manifestation, laboratory tests and demographic of 274 patients with chronic
urticarial in Sari, Iran. Methods: In this
descriptive-cross sectional study, we evaluated 274 patients (195 female and 79
male) with chronic urticaria who were referred to allergic centers (Booali and
Tooba clinics) in Sari ,for 4 and half years (Dec 2008tillMarch 2012). All of
them had ages between 2 to 75 years. We evaluate demographic characteristics,
different laboratory tests such as CBC, ESR, CH50, C3, C4, IgE, and anti-thyroid
and helicobacter pylori antibodies in them. Results:
Chronic urticaria is more common from 20 to 40 years of age in both genders
(55%). Physical urticaria was found in 42 patients, with more common cases of
dermographism (n=21). Angioedema was seen in 144 patients (52.5%). Total IgE increased
in 128 of cases (46%). History of allergic disorders were positive in 128 cases
(46%).Anti thyroid antibodies increased in 50 cases (18.24%) with 4 patients
with abnormal thyroid function tests. Helicobacter Pylori antibodies, IgG and
IgA were increased in 69.23% whom 90% were above 18 years old. Antinuclear
antibody, CH50, C3, C4, Stool exam were normal in all of them. Conclusions:
In Chronic urticaria often laboratory tests including CBC, liver
and kidney functions are normal and better not to be recommended.
http://rjms.iums.ac.ir/article-1-2655-en.pdf
Urticaria
Laboratory tests
Thyroid antibody.
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
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29
article
Comparison of cytomorphometry changes in oral mucosa of smoker and hookah users
Safoura Seifi
1
Farideh Feizi
2
Mohammad Mehdizadeh
3
Soraya Khafri
4
Behrang Ahmadi
5
Babol Universirty of Medical Sciences
Babol Universirty of Medical Sciences
Babol Universirty of Medical Sciences
Babol Universirty of Medical Sciences
Babol Universirty of Medical Sciences
Background: Oral
mucosa of cigarette and hookah users is more susceptible for malignant changes,
so the purpose of this study is to assess the impact of cigarette and hookah on
morphometry features of oral mucosa. Methods: In this
Historical Cohort study, Cytological smears prepared from three regions of oral
mucosa (Buccal mucosa, lateral border of tongue and floor of the mouth) in 40 smokers, 40 hookah users ,
40 non-smoker and non-hooka users were stained by Papanicolaou method. A
quantitative and qualitative change in cytology smears was evaluated in each
slide. Quantitative evaluation of 50 cells per slide was performed with Motic
Plus2 software. Practitioners were matched with age and sex. Results: Increased
nuclear size, nuclear to cytoplasmic ratio, Ferret ratio, reduced size of
cytoplasm was observed in cigarette users, hookah users, non-smokers and non
hookah users respectively (p<0.001). No Significant difference in
karyorrhexis, multilobed nuclei and cytoplasmic vacuolization in buccal
mucosa,tongue and floor of the mouth of cigarrete, hookan users(p=0.8) and non
smoker-non hookan users was seen. (p3=0.9) but inflammation(p< 0/001) and
candidiasis (p=0/002)were more in smokersand hookah users than non smoker and
non hookah users respectively. Conclusions: Cigarette and hookah
are effective in cyto-morphometric changes of oral mucosa, but in this area,
The effect of cigarette is more than hookah.
http://rjms.iums.ac.ir/article-1-2656-en.pdf
Cigarette
Hookah
Cytomorphometric
Cytology
Oral mucosa
per
Iran University of Medical Sciences
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article
A Combination Training of Pelvic Floor Muscles and Core Muscles in Improvement of Stress Urinary Incontinence
Azizeh Farzinmehr
1
Azar Moezzi
2
Jalil Koohpayezadeh
3
Tehran university of Medical Sciences
Tehran university of Medical Sciences
Tehran university of Medical Sciences
Background:
Stress
urinary incontinence (SUI) ,the most common type of UI, is the
involuntary leakage of urine from the urethra with an increase in
intra-abdominal pressure. Pelvic Floor Muscle( PFM) dysfunction in women may
lead to SUI . Thus, one of
the effective managements in SUI is Pelvic Floor Muscle Training. PFM strength
has a strong relationship with abdominal muscles work, therefore, in the
present study, a combination training of PFMT and core exercises is used for
the management of SUI. Methods: The
study was a semi experimental control trail which was approved by the Ethical Committee of Medical Sciences/Tehran
University , Main participants were 22 women with proven stress urinary
incontinence , VAS score , IQOL questionnaire , PFM strength ,PFM static and PFM dynamic tests were evaluated pre and
post intervention. The subjects were conducted a three-weekly training program
under supervision Results: Conservative
management & exercise therapy is recommended as a first line treatment for
SUI. The
results of this
study showed that combined exercise training of core muscles & PFM was
associated with the improvement of SUI, in reducing incontinency, increasing the score of
IQOL questionnaire, improvement of the PFM strength and endurance in a short
duration. There were significant
differences in our variables pre and post intervention,
including 60% increasing of the total score of IQOL questionnaire, 57%
reduction in VAS score and 76% increase in pelvic floor muscle strength . Conclusions: Our
findings showed the positive effects of this new exercise protocols in
improving the physical condition and quality of life in all participants.
http://rjms.iums.ac.ir/article-1-2657-en.pdf
Stress Urinary Incontinence
Combination training
core muscles
pelvic floor muscles
semi experimental study (before & after)
exercise therapy.
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
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article
Comparison of effectiveness of two education programs about improvement of edible oil consumption
Ensiyeh Seyed Rezazadeh
1
Mohammad Reza Vafa
2
Fariba Kolahdooz
3
Hamideh Koosha
4
Fathollah Poorali
5
Fariba Mahmoodpour
6
Fariba Bakhshiyan
7
Mohammad Saleh Al - e Molana
8
Mahboobeh Shaneshin
9
Saeedeh Vaseti
10
Tehran university of Medical Sciences
Tehran university of Medical Sciences
Tehran university of Medical Sciences
Tabriz University of Medical Sciences
Tabriz University of Medical Sciences
Tabriz University of Medical Sciences
Tabriz University of Medical Sciences
Tabriz University of Medical Sciences
Shahid Beheshti University of Medical Sciences
Tabriz University of Medical Sciences
Background:
The aim of the study is to assess knowledge and behavior of participants about
dietary fats pattern. Also, our goal was to design a nutrition education
program about dietary fat intakes which is relatively brief and low cost in
terms of time and material. Methods: In this
experimental study we recruited three groups of household women under the cover
of health centers of Tabriz city as Random-cluster sampling method. Group A (n= 90) participated for 3 sessionsand
group B (n= 86) for 5 sessions education intervention about dietary fat
pattern. Also group C (n= 90) were allocated as control group. We randomly
selected some partners (n= 65) of intervention groups (group A and B), as
reinforces factors, the other control group. For evaluation, a knowledge and
behavior questionnaire was administrated to all groups. Furthermore, the
effectiveness of education was compared among two intervention groups with
different attendance classes. Results: For mean scores
knowledge, no significant difference existed between groups. Mean score of
behavior were less than 50% in all groups [group A: 49.3±16.5, group B:
44.3±17.7, group C: 43.57±13.5 and group M: 50.51±18.66]. Mean scores of
knowledge and behavior showed a significant difference in the intervention
groups(post-test versus pre-test)[ group A: 79.4±23.6 and group B 83.22±21.5, p<0.001].
Different impacts of class attendances have not significant effectiveness for
knowledge and behavior to compare two intervention groups (groups A and B), but
significant compared control group (group C) (p=0.0001). Conclusions: Women
had low knowledge about optimal dietary fat pattern and behavior levels were
poor. Short time education program was effective for household women.
http://rjms.iums.ac.ir/article-1-2658-en.pdf
Education
Effectiveness
Edible oil
Knowledge
Behavior.
per
Iran University of Medical Sciences
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article
The effects of Tocotrienolsenriched canola oil on glycemic control and oxidative stress in patients with type 2 diabetes: a double blind randomized clinical trial
Neda Haghighat
1
Mohammadreza Vafa
2
Shahryar Eghtesadi
3
Iraj Heidari
4
Agha Fatemeh Hoseini
5
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Background:
Tocotrienolswhich
were neglected in the past, today get attentions due to their antioxidant and
none-antioxidant activity. The purpose of this study was to determine the
effects of 8 weeks consumption of 15 ml T3 enriched canola oil (200mg/day T3)
on glycemic controlandoxidative stress in type 2 diabetic patients. Methods:
Thisclinical
trial was conducted on 50 patients with type 2 diabetes mellitus (FBS> 126
mg/dl) who were randomly assigned in two (intervention and control) groups.
Intervention group (n=25) received 15 ml T3 enriched canola oil (200mg/day T3) or pure canola oil. Blood
samples of patients were collected to measure fasting blood glucose (FBS), fasting insulin, Total Antioxidant Capacity
(TAC), Malon Di Aldehyde (MDA) levels and Homeostasis Model Assessment for
Insulin Resistance (HOMA-IR).Physical activity levels and nutrients intake
were evaluated before and after intervention and were compared between the
groups. Results: FBS, TAC, and MDA were declined significantly by 20, 25 and 35%
respectively, in T3 treated group. At the end of the study, intervention group
had significantly lower FBS, MDA than control group. A non-significant decrease
was also observed in HOMA-IR in intervention group with no changes in insulin
levels. Conclusions: These data suggest that tocotrienols
may improve glycemic status, oxidative stress indicators, in diabetic patients
but the effects on insulin sensisivity need to investigate more in future.
http://rjms.iums.ac.ir/article-1-2659-en.pdf
Tocotrienols
Glycemic status
Oxidative stress
Type2 diabetes mellitus.
per
Iran University of Medical Sciences
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article
Potential Impact Fraction of modifying selected risk factors on burden of cardiovascular disease in Iran: comparative risk assessment
Manoochehr Karami
1
Farzaneh Mobasheri
2
Fatemeh Khosravi Shadmani
3
Hamadan University of Medical Sciences
Fasa University of Medical Sciences
Shahid Beheshti University of Medical Sciences
Background: Increasing the prevalence of risk
factors of cardiovascular diseases, emphasizes on health policy, priority
setting and preventing cardiovascular diseases deaths. This study aimed to
assess Potential Impact Fraction of modifying selected risk factors on burden
of cardiovascular disease in Iran. Methods: To calculate
Potential Impact Fraction (PIF) of risk factors WHO comparative risk assessment
(CRA) methodology was used. Data on the Prevalence of the risk factors were
obtained from 3rd national Surveillance of Risk Factors (Diabetes,
hypertension, central obesity, Hypercholesterolemia) of Non-Communicable
Diseases (SuRFNCD-2007) and data on corresponding measures of effect were
derived from Tehran Lipid Glucose Study (TLGS). Then joint effect of risk
factors was calculated. Results:
The joint effect of modifying selected risk factors to the theoretical minimum
risk level i. e. zero for adult female 59.4% (95% uncertainty intervals: 30.0 –
76.0) and for males 37.0% (95% uncertainty intervals: 21.7-50.2) of burden of cardiovascular disease
are avoidable. The corresponding value was greater than in females at plausible
and feasible minimum risk levels. Conclusions: Our
study results which were reported based on attributable burden support the
rational for implementing a national- wide and repeated screening for risk
factors among adults.
http://rjms.iums.ac.ir/article-1-2660-en.pdf
Risk factors of cardiovascular disease
Joint effect
Potential Impact Fraction
Disability Adjusted Life Years
Comparative risk assessment.
per
Iran University of Medical Sciences
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article
Relationship between general health and self-efficacy in women referred to health center No.2 in Chaloos (2012)
Mahnaz Solhi
1
Seyedeh Somayeh Kazemi
2
Hamid Haghni
3
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Background: Women's
health is the base of family and society's health. Self-efficacy is one of the
factors which would lead to promotion of general health in women. Methods: In this
descriptive cross-sectional- analytical study, general health status of 130
women referring to health center No.2 in Chalus were selected by simple random
sampling. They were asked to complete a standard General health questionnaire
(GHQ-28) and standard Self-efficacy questionnaire (General Self-Efficacy
Scale-GSE) (Schwartzer & Jerusalem). Results: Mean and
standard deviation of general health and self-efficacy were 20.92±14.09
(desirable) and 29.76±6.07 (moderate).Also 34.6% of women complained from
physical symptoms 36.2% had anxiety and sleep disorder 53.1% had impairment
in social functioning and 14.6% had some symptoms that indicated depression.
In general, 27% of women had some kind of health problems. There were
signification relationship between general health and marital status, between
marital status and depression, and between general health and self-efficacy. Conclusions: General
health and self-efficacy in these women are inadequate and planning educational
program for promoting general health based on self-efficacy theory is
necessary.
http://rjms.iums.ac.ir/article-1-2661-en.pdf
General health
Self-efficacy
Women.
per
Iran University of Medical Sciences
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article
The effects of brucellosis vaccination in domestic animal on human brucellosis in IRAN
Hossein Esmaeili
1
Hasan Esmaeili
2
Karim Amiri
3
University of Tehran
Tehran University of Medical Science
Iran veterinary organization
Background: Brucellosis
is an important zoonosis that constitutes a serious hazard to public health.
Control and eradication programmes have been implemented in many countries
where brucellosis exists. Vaccination is the best method for controlling the
infection and this must be the first step for the elimination of the disease.
In Iran,
Malta fever was first recognized in 1932 and control of animal brucellosis
began in 1949. Our aim was to investigate the effects of animal vaccination in Iran from 1983
to 2008 on the incidence of human brucellosis. Methods: In this
descriptive study, the relationship between the domestic animals vaccination
with the incidence of human brucellosis was assessed with the SPSS software, which Pearson
correlation coefficient was used for this purpose Results: Statistical
analysis showed that Pearson correlation coefficient of cattle vaccination and
human brucellosis(r= -0.48), sheep and goat vaccination and human incidence
rate (r=-0.44) are negative (p<0.05). Conclusions: Animal
vaccination seemed to have decreased the human incidence. The control of
brucellosis can be achieved if the animal population’s resistance to disease
would be increased. It is accepted that vaccination is more acceptable and
effective than other methods applied for this purpose. Combination of health
education and animal vaccination programs for control of human brucellosis are
very important.
http://rjms.iums.ac.ir/article-1-2662-en.pdf
Brucella melitensis
Sheep
Goat
cattle
Vaccination
brucellosis
Brucellosis.
per
Iran University of Medical Sciences
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article
The relationship of anthropometric indices with PMS and it’s severity in female students of Tehran University of Medical Sciences
Vida Mohammadi
1
Farzad Shidfar
2
Sahar Keshtkar Aghababaee
3
Parisa Mokhtari
4
Roya Mohammadi
5
Mahmoud Reza Gohari
6
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Shiraz University of Medical Sciences
Tehran University of Medical Sciences
Background: It
is believed that overweight and obesity are involved in the etiology of
menstrual problems by changing the balance of steroid hormones and sex hormone
binding globins. This
study examined the
association between anthropometric
indices with premenstrual syndrome (PMS) and its severity in female students. Methods: This cross-sectional study involving 365 women living
in student dormitories of Tehran University of Medical Sciences,, was conducted in 1391. Sampling was random cluster. Seca stadiometer and scale to measure height and weight at standard conditions and non-elastic tape to measure waist and hip circumferences were used. Then waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and index Conicity (C-Index) were calculated. To assess PMS and its’ severity provisional diagnosis of premenstrual syndrome form and
Premenstrual Symptoms Screening Tool-PSST were employed. Data was analyzed with statistical software SPSS v.16 using the Kolmogorov-Smirnov test. To investigate the relationship between variables Spearman correlation coefficient was used and 0.05> P-value was
considered significant. Results: There was a significant correlation between waist circumference (P-value: 0.046, r: 0.123) WHR (P-value: 0.043, r: 0.125), and
WHtR (P-value: 0.045, r: 0.123) and PMS risk, but there
was no significant
association between other indicators and PMS. Conclusions: Increase in waist circumference,
WHR, and WHtR associated with increased risk of PMS and its
severity.
http://rjms.iums.ac.ir/article-1-2663-en.pdf
Premenstrual syndrome
Anthropometric indices
Female students.