Razi Journal of Medical Sciences

fa تأثیر یک دوره تمرین بازتوانی قلبی بر سطوح سرمی گالکتین-3 در بیماران قلبی (CABG و PCI) The Effect of a Cardiac Rehabilitation Training Course on Serum Levels of Galectin-3 in Cardiac Patients (CABG and PCI) فیزیولوژی ورزش Exercise Physiology پژوهشي Research <div style="text-align: justify;">زمینه و هدف: یکی از مهمترین بیماریهای رایج در جهان بیماریهای قلبی- عروقی میباشد که با شناخت مکانیسم مارکرهای قلبی مانند گالکتین-3 میتوان به کاهش سطح این بیماری کمک کرد و از راهکارهای درمانی بازتوانی بیماریهای قلبی- عروقی، برنامههای ورزشی و تمرینی میباشد. از آنجایی که تأثیر تمرین با شدت متوسط بر روی سطوح سرمی گالکتین-3 (GAL-3) در این بیماران همچنان ناشناخته مانده است، لذا هدف این مطالعه بررسی سطوح سرمی گالکتین-3 (GAL-3) بیماران قلبی (CABG و PCI) در پاسخ به یک دوره تمرینات با شدت متوسط میباشد. روش کار: در این مطالعه نیمه تجربی تعداد 30 نفر بیمار مرد که مبتلا به بیمار قلبی که تحت (CABG یا PCI) قرار گرفته بودند به دو گروه تمرین و کنترل تقسیم شدند. گروه تمرین به مدت هشت هفته و هر هفته سه جلسه و هر جلسه 45 دقیقه به فعالیت هوازی با شدت متوسط بر روی تردمیل پرداختند و گروه کنترل در این مدت، تنها فعالیتهای روزمره و مراقبتهای روزمره پزشکی داشتند. سطوح سرمی پروتئین گالکتین-3 در مرحله پیش آزمون و پس آزمون مورد اندازهگیری قرار گرفت. به منظور تجزیه و تحلیل دادهها از آزمون تی وابسته و تی مستقلبا استفاده از نرم افزار آماری spss نسخه 20 استفاده شد. یافته‌ها: بررسی تغییرات درون گروهی نشان داد که در گروه تمرین سطوح سرمی گالکتین -3 در مرحله پس آزمون نسبت به پیش آزمون کاهش معناداری داشت (001/0>p  ) در حالی که در گروه کنترل تغییرات معناداری مشاهده نشد (617/0=p )، همچنین بررسی تغییرات بین گروهی نشان داد سطوح سرمی گالکتین -3 در مرحله پس آزمون نسبت به گروه کنترل نیز معنادار بود (008/0=p ). نتیجه‌گیری: بر اساس یافتههای این مطالعه سطوح سرمی گالکتین-3 در بیماران قلبی  تحت (CABG و PCI) بعد از یک دوره تمرینات بازتوانی قلبی با شدت متوسط کاهش یافت لذا استفاده از تمرینات بازتوانی قلبی با شدت متوسط میتواند راهکاری جهت بهبود بیماریهای قلبی محسوب شود.</div> <div style="text-align: justify;">Background & Aims: Cardiovascular diseases are one of the common diseases and one of the major causes of death in the world, which in addition to imposing high costs, reduces the quality of life in society. The most common treatment for coronary disease is coronary artery bypass surgery (CABG), during which the coronary artery is blocked by grafting veins that are usually removed from the leg, between the part before the stenosis and the part after the stenosis. It creates a sub-way to increase the blood flow to the blood-deficient area and try to establish reperfusion in the coronary artery. Also, today, percutaneous coronary intervention (PCI) is widely used in the world, which improves the survival rate and quality of life in patients with coronary problems, especially in people with chest pain or heart infarction. Gives Inflammation and factors such as genetics, nutrition, lifestyle, and psychological issues can affect this disease. One of the most important common diseases in the world is cardiovascular disease, by knowing the mechanism of cardiac markers such as galectin-3, can help reduce the level of this disease, and among the therapeutic strategies for the rehabilitation of heart diseases- Vascular, sports, and exercise programs. The effect of moderate-intensity exercise on serum levels of galectin-3 (GAL-3) in these patients remains unknown. Although studies have been conducted on the effects of physical activity on various factors related to heart disease, because no research was found on the effect of physical activity on these factors in a sample of these patients, and the results obtained in this field are both contradictory, therefore, the effect of regular aerobic activity on Gal-3 concentration in these cardiac patients remains unknown. Therefore, the research seeks to answer this question, does a period of moderate-intensity aerobic training have a significant effect on the goal of helping to clarify the serum concentration of galectin-3 factor in heart patients (CABG and PCI)? Methods: This research was carried out with the available sampling method and it is a semi-experimental type, which was approved by the Research Institute of Physical Education and Sports Sciences with the Code of Ethics IR.SSRC.REC.1402.228. In this study, 30 men with heart disease who underwent surgery (CABG or PCI) participated. These people were referred to the prevention and cardiac rehabilitation department of Imam Ali (AS) Heart Research, Training and Specialized Treatment Center in Kermanshah. By completing the written consent to participate in the research and after clinical examinations under the supervision of a sports medicine specialist, their height, weight, and age information was recorded and they were placed in two training groups (15 people) and control (15 people). The exercise group did aerobic activity with moderate intensity on the treadmill for 3 sessions each week and 45 minutes each session, and the control group had only daily activities and daily medical care during this period. Galectin-3 protein serum levels were measured in the pre-test and post-test stages. To analyze the data, dependent t-test and independent t-test were used using spss version 20 statistical software. Results: Examining the changes within the group showed that in the training group, the serum levels of galectin-3 in the post-test stage had a significant decrease compared to the pre-test (p<0.001), while no significant changes were observed in the control group (617/ p=0), also the examination of inter-group changes showed that the serum levels of galectin-3 in the post-test phase were also significant compared to the control group (p=0.008). Conclusion: Our findings in this study first indicated that galectin-3 levels were high in heart patients who underwent percutaneous intervention (PCI) and bypass surgery (CABG). Which seems to be caused by the conditions of surgery, medical interventions, and psychological conditions after the operation, which may be part of the inflammatory response caused by the disease or the anti-inflammatory regulation against the disease. After eight weeks of cardiac rehabilitation with moderate-intensity aerobic exercise, the serum levels of galectin-3 in these patients significantly decreased compared to the control group, which seems to show that this recovery is after performing a period of regular physical activity related to Neuro-hormonal factors and from the way of strengthening the anti-diabetic defense and modulating the respiratory pressure, which further limits inflammation and fibrosis. Considering that it has been determined that the increase in the serum levels of this factor is related to the increase in the risk of heart disease in people with heart disease. Therefore, the reduction of galectin-3 levels with the intervention of moderate-intensity aerobic exercises can be a confirmation of the ability of these physical activities to help prevent the progression of the disease and reduce the complications caused by heart disease in this individual. The general results of the studies that we had access to indicate the important point that the increase in the level of galectin-3 in heart patients worsens the condition of these patients, and also in the descriptive studies the relationship between the serum levels of galectin-3 and the increase Cardiac dysfunction has been observed in heart patients. But at the same time, although there are reports that intense sports activity can increase the serum levels of galectin-3, nevertheless, it seems that the intensity of the activity has a significant effect on increasing the levels of galectin-3, so that activity with High intensity can increase the levels of this biomarker. Based on the findings of this study, the serum levels of galectin-3 in heart patients undergoing (CABG and PCI) decreased after a period of moderate-intensity cardiac rehabilitation exercises, so the use of moderate-intensity cardiac rehabilitation exercises can be a solution to improve the disease.</div> تمرین ورزشی, بازتوانی قلبی, گالکتین-3, عمل جراحی بای پس قلبی Sports Training, Cardiac Rehabilitation, Galectin-3, Cardiac Bypass Surgery 1 9 http://rjms.iums.ac.ir/browse.php?a_code=A-10-7912-1&slc_lang=fa&sid=1 Houshyar Fashi هوشیار فشی hfashi86@gmail.com 3900319475328460090396 0009-0002-5164-7333 No PhD student in Cardiovascular and Respiratory Sports Physiology, Urmia University, Urmia, Iran دانشجوی دوره دکترای فیزیولوژی ورزشی قلب و عروق و تنفس، دانشگاه ارومیه، ارومیه، ایران Akbar Nouri Habashi اکبر نوری حبشی Akbarnori52@gmail.com 3900319475328460090397 3900319475328460090397 Yes Assistant Professor, Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia, Iran استادیار، گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزش دانشگاه ارومیه، ارومیه، ایران Ali Soroush علی سروش Ali.soroush.mhr@gmail.com 3900319475328460090398 3900319475328460090398 No Professor, Department of Rehabilitation and Sports Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran استاد، گروه بازتوانی و پزشکی ورزشی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران Javad Tolouei Azar جواد طلوعی آذر j.tolouei@gmail.com 3900319475328460090399 3900319475328460090399 No Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia, Iran دانشیار، گروه فیزیولوژی ورزش دانشکده تربیت بدنی و علوم ورزش، دانشگاه ارومیه، ارومیه، ایران