Razi Journal of Medical Sciences

fa تاثیر نوتروفیل بر لنفوسیت و پوکی استخوان The Effect of Lymphocyte Ratio on Pathophysiology of Osteoporosis پزشکی Medical پژوهشي Research <div style="text-align: justify;">زمینه و هدف: بیماری استئوپروز یکی از بیماریهایی میباشد که اغلب در سنین بالای۷۰ سال و به صورت مزمن رخ میدهد که شناسایی فاکتورهای موثر بر آن دارای اهمیت میباشد. بنابراین هدف از این مطالعه بررسی ارتباط بین نسبت نوتروفیل به لنفوسیت و پوکی استخوان میباشد. روش کار: این مطالعه بر روی 71 نفر (42 نفر (2/59 %) دارای پوکی استخوان و 29 نفر (8/40 %) فاقد پوکی استخوان) انجام گرفت پس از اخذ رضایت از افراد و ثبت اطلاعات دموگرافیک، نسبت نوتروفیل به لنفوسیت نیز ثبت شد. آزمونهای کای اسکویر و من ویتنی جهت مقایسه دادهها استفاده شد. یافته‌ها: یافتههای مطالعه ما نشان داد که میانگین سن در افراد دارای پوکی استخوان به صورت معناداری بیشتر و میانگین قد و وزن در افراد دارای پوکی استخوان به صورت معناداری کمتر از بیماران بدون پوکی استخوان بود و اما مشخص شد که میانگین نوتروفیل، لنفوسیت و نسبت NLR در افراد دو گروه مورد مطالعه تفاوت آماری معناداری نداشت و همچنین NLR با شدت پوکی استخوان ستون فقرات و فمور نیز ارتباطی نداشت. نتیجه‌گیری: با توجه به عدم ارتباط NLR با پوکی استخوان و شدت آن، به نظر میرسد که NLR تاثیری بر فیزیوپاتولوژی پوکی استخوان ندارد، هر چند مطالعات بیشتر جهت بررسی این ارتباط مورد نیاز است.</div> <div style="text-align: justify;">Background & Aims: Every year, a large number of people in the world face the problem of osteoporosis, and to diagnose it, they use the diagnostic method of bone density testing. There is a method called dual-energy X-ray absorptiometry (DEXA), in which the bones of the pelvis and spine are scanned using X-rays, and the amount of bone density is determined according to the age and gender of people. Because X-rays are used in this method, there are risks for the patient due to the side effects of X-ray radiation. Also, the DEXA method is not a cheap method for measuring bone density. Therefore, it is important and necessary to identify a solution based on which this problem can be identified with a faster and cheaper method. A complete blood cell count test (CBC diff) is a simple, low-risk, available, and inexpensive method. If the occurrence of osteoporosis can be understood by analyzing the data from the CBC diff test, which is used in this study, the ratio of neutrophil cells to lymphocytes, is very important. Osteoporosis is the most common metabolic bone disease and an epidemic disease in the population. This disease is an important risk factor for pathological fractures, which causes mortality and morbidity and additional costs to human society. Several epidemiological studies have been conducted concerning osteoporosis in different parts of the world. According to these estimates, about 75 million people in Europe, Japan, and America are suffering from osteoporosis. For example, 30% of post-menopausal American women, 87% of Australian women over 70, and 50% of Taiwanese women at this age face the problem of osteoporosis. Also, the amount of bone mineral density in Asian and Caucasian races was lower than in other races. This problem, which is justified by the smaller size of these people, has caused more hip fractures in Asia, such that 30% of all these fractures occur in Asia. Osteoporosis is an important health-threatening issue for postmenopausal women, which makes them prone to fractures, and such fractures are associated with high morbidity and mortality. Osteoporosis, which is the most common bone disease in humans, is a skeletal disease that is characterized by a decrease in bone strength and puts people at risk of fracture. Bone strength is dependent on several qualities in bone, among which only bone density can be evaluated and other bone qualities (including the size of hydroxyapatite crystals, correlation of trabeculae, degree of mineralization, small destructions, etc.) cannot be measured. Bone fractures and their complications are the clinical result of osteoporosis. Although the most common fracture sites are: the proximal part of the femur (thigh bone), the vertebrae (vertebrae), and the distal part of the forearm bones (wrist), since osteoporosis is a widespread bone disease and causes a decrease in bone mass throughout the system becomes skeletal, therefore, almost all fractures in the elderly are to some extent caused by a decrease in bone density. A fracture may heal completely or lead to chronic pain, physical disability, or even death. The most dangerous complication of osteoporosis is femur fractures; A complication that can lead to a 10-20% increase in mortality during the first year after fracture. In addition, about 25% of patients with hip fractures may need long-term care in nursing homes, and only 30% of patients regain their pre-fracture ability. Osteoporosis is a chronic disease which commonly occurs in people after the age of 70 and it is important to identify the contributing factors. Therefore, this study aims to examine the relationship between neutrophil to lymphocyte ratio and osteoporosis. Methods: This study was conducted on 71 people (59.2%) with osteoporosis and 29 people (40.8%) without osteoporosis. Informed consent was obtained from the subjects and demographic data was recorded; neutrophil to lymphocyte ratio was also recorded. Chi square and Mann–Whitney U test were used to compare the data. Results: The findings of the study revealed that the average age of subjects with osteoporosis was significantly higher and the average height and weight of subjects with osteoporosis was significantly lower than subjects without osteoporosis. No statistically significant difference was found between the two groups of study in terms of the mean neutrophil to lymphocyte ratio (NLR). NLR was not associated with spinal or femoral Osteoporosis severity either. Conclusion: The present study was conducted to investigate the relationship between the ratio of neutrophils to lymphocytes and osteoporosis. In this study, 71 people, of which 42 people (59.2%) had osteoporosis and 29 people (40.8%) did not have osteoporosis. The average age of people with osteoporosis was significantly higher than that of patients without osteoporosis (62.62 versus 53.52 years). It was also found that the average height of people with osteoporosis was significantly lower than that of patients without osteoporosis. 159.87 against 154.05 cm). It was also found that the average weight of people with osteoporosis was significantly lower than that of patients without osteoporosis (79.33 vs. 68.78 kg). However, no statistically significant difference was observed based on BMI. In the end, it was found that the mean of neutrophil, lymphocyte, and NLR ratio in the two groups studied had no statistically significant difference, and it was also not related to the severity of osteoporosis of the spine and femur. The findings of our study showed that the average age in people with osteoporosis was significantly higher and the average height and weight in people with osteoporosis was significantly lower than in patients without osteoporosis, but it was found that the average neutrophil, lymphocyte, and ratio There was no statistically significant difference in NLR in the subjects of the two studied groups, and there was no relationship between NLR and the severity of osteoporosis of the spine and femur. Therefore, considering the lack of relationship between NLR and osteoporosis and its severity, it seems that NLR does not affect the physiopathology of osteoporosis, although more studies are needed to investigate this relationship. As there is no association between NLR and osteoporosis and the related severity, it seems that NLR has no effect <a name="_Hlk138894411">on Pathophysiology of osteoporosis</a>, though more studies are required to examine this relationship.</div> نوتروفیل, لنفوسیت, پوکی استخوان Neutrophil, Lymphocyte, Osteoporosis 185 191 http://rjms.iums.ac.ir/browse.php?a_code=A-10-7607-1&slc_lang=fa&sid=1 Masood Dindari Parizi مسعود دینداری پاریزی MD_parizi@yahoo.com 3900319475328460081655 0009-0005-9372-1257 Yes Department of Cardiovascular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran گروه قلب و عروق، دانشگاه علوم پزشکی شیراز، شیراز، ایران