Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1401
9
1
gregorian
2022
12
1
29
10
online
1
fulltext
fa
نقش فعالیت جسمانی در تعدیل عوارض عصبی-روانی ناشی از کووید-19: مروری روایتی
The Role of Physical Activity in Modulating Covid-19 Neuropsychological Complications: A Narrative Review
روانشناسی بالینی
Clinical Psychiatry
مروري
review article
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black">همهگیری </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black">کووید</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black">-19 (</span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">COVID-19</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black">)، یک مسئله جهانی تأثیرگذار بر سبک زندگی مردم در سراسر جهان است. علائم تنفسی و گوارشی با علائم عصبی روانپزشکی کوتاه مدت و بلندمدت و عواقب طولانی مدت مغزی همراه است. اگرچه تحقیقات زیادی برای بررسی عوارض مختلف این بیماری شده است، اما هنوز نگرانی­های جدی در مورد شناسایی عوارض عصبی-روانی این بیماری وجود دارد، که بهترین رویکرد درمانی را محدود می­کند. برنامه­های ورزشی و سطوح فعالیت جسمانی تعدیل کننده­های شناخته شده تظاهرات بالینی و پیش­آگهی در بسیاری از بیماری­های مزمن هستند. این مرور روایتی شواهدی در مورد سندرم پس از </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">COVID-19</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black"> را برای کمک به شناخت بهتر عوارض عصبی-روانی این بیماری خلاصه میکند و توضیح میدهد که چگونه فعالیت جسمانی منظم ممکن است بر عوارض عصبی-روانی </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">COVID-19</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black"> موثر باشد و میتواند اثرات بلندمدت عوارض عصبی-روانی </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">COVID-19</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black"> را کاهش</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black"> دهد. </span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span></span></span></span><br>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Since 2020, the COVID-19 pandemic, triggered by SARS-CoV-2, represents the major global issue affecting the lifestyle of people around the world. Wuhan, China was the first city to detect the SARS-CoV-2 virus, but the virus soon spread around the world, forcing the World Health Organization to declare a global epidemic on March 11, 2020 (1). Previous pathological conditions or comorbidities such as old age are one of the main causes of premature death and increased morbidity and mortality due to COVID-19 (4). Inactivity due to hospitalization and bed rest and reduced physical activity due to constant quarantine and social distancing can reduce the ability of organ systems to resist viral infection and the risk of damage to the immune, respiratory, and Increase cardiovascular systems, musculoskeletal and nervous system (4). On the other hand, the health benefits of physical activity, from cardiovascular health to mental health, have been well established (5). Decreased physical activity and increased sedentary behaviors were reported during quarantine in several populations, including children and patients with a variety of medical conditions (6). In general, COVID-19 lifestyle changes have led to a decrease in physical activity and consequently more inactivity in different parts of the community, which can pose a risk to general or mental health, especially for certain populations. In this study, we have tried to review the neurological and psychological effects of COVID-19 and the resulting lifestyle changes, and specifically the role of exercise in relation to these effects.</span></span></span></span></span></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Central nervous system (CNS) and peripheral nervous system (PNS) manifestations can occur during and after COVID-19, but the underlying mechanisms, symptomatology, and frequency of these complications are not well understood (7). Limited postmortem studies have shown signs of hypoxic brain damage and inflammatory neurological changes in the brainstem, while neuropathological data from the PNS are almost non-existent. Due to the cause, direct invasion of acute respiratory syndrome of COVID-19 virus to nerve tissue has been suggested in several cases, but autoimmune damage and neurological complications related to intensive care management can also be effective. The contribution of these mechanisms to the overall burden of CNS and PNS complications of COVID-19 is unknown (7). Follow-ups in Germany and the United Kingdom have shown that neuropsychological symptoms after COVID-19 in 20 to 70% of patients, even in young adults, last for months after the onset of respiratory symptoms, suggesting brain involvement persists (9). COVID-19, which enters through angiotensin-converting enzyme receptors, can damage endothelial cells, leading to inflammation, thrombosis, and brain damage. In addition, systemic inflammation leads to a decrease in monoamines and neurotrophic factors and activation of microglia, which leads to an increase in glutamate and N-methyl-d-aspartate-3 and excitatory toxicity, and these factors cause the onset or exacerbation of existing neuropsychiatric symptoms. They are already (9). However, the extent of damage caused by the COVID-19 pandemic strain is still speculated; it has recently been suggested that irregular neuro-endocrine-immune interactions may be behind psychiatric manifestations observed in quarantined individuals (12, 13). Persistent and increased stressful events can direct immune, endocrine, and nervous system responses primarily through hypothalamic-pituitary-adrenal (HPA) mediated dysfunction (12), and changes in the levels of systemic inflammatory mediators or the brain predispose individuals to pathological psychological conditions. It acts like anxiety and depression. In addition, stress can be a potential trigger for neuroinflammation, a term used to indicate an imbalance or intensification of immune signals in the brain that can lead to several disorders such as aggression, psychosis, depression, and anxiety disorders (12). Covid 19 has also been shown to alter nerve growth factors that may affect the neuropsychological effects of Covid-19 (16,17). </span></span></span></span></span></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">The current situation of the epidemic as a stressful situation has led to a decrease in physical activity in the general population. Considering that exercise training has been shown to be useful in a number of pathologies with which post-COVID-19 syndrome bears similarities in terms of symptoms and possible pathogenic mechanisms; therefore, it is necessary to consider the potential optimal effect that this has on the improvement or prevention of COVID-19 neuropsychiatric complications. Despite the benefits of exercise, there are limitations to sports activities for different people, which can endanger the neurological and mental health of different people, especially people with underlying diseases or people with special conditions such as patients, children and the elderly. A review of a study that specifically looked at the effect of exercise training on nerve function in patients with COVID-19 were not found; However, based on trials, general recommendations for exercise training in patients have been identified that may be beneficial to the neurocognitive effects of COVID-19 in both healthy individuals and those with COVID-19 syndrome. </span></span></span></span></span></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">There is ample evidence that appropriate, supervised exercise may be an effective multisystem therapy to reduce the neuropsychological effects of COVID-19 syndrome, which is commensurate with the variety of cases and symptoms. Further studies on the effects of exercise-based therapies on post-COVID-19 syndrome are needed to provide practical insights into what type of exercise training should preferably be prescribed, with an emphasis on weight management and adherence strategies. In addition, the effect of post-COVID-19 syndrome on neuropsychological complications of certain demographic groups such as children, adolescents or the elderly remains unknown; Even exercise training and rehabilitation programs for neuropsychiatric complications in these individuals are not known. Overall, a multidisciplinary and integrated approach, part of which is related to sports science, is essential to improve individuals' clinical conditions; nevertheless, neurological and psychological aspects must be integrated into the assessment, as well as the social impact that this pathology entails. Due to the limitations of studies, new proposals for long-term research into the disease in an effort to restore full function and return to previous life are recommended.</span></span></span></span></span></span></span></span></span></span></div>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="tab-stops:10.5pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
کووید-19, فعالیت جسمانی, عوارض عصبی, عوارض روانی
Covid-19, Physical activity, Neurological complications, Psychological complications
181
192
http://rjms.iums.ac.ir/browse.php?a_code=A-10-6429-1&slc_lang=fa&sid=1
Akbar
Ghalavand
اکبر
قلاوند
3900319475328460070256
3900319475328460070256
No
PhD in Exercise Physiology, Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran
دکتری فیزیولوژی ورزشی، مرکز تحقیقات گوارش و کبد کودکان، دانشگاه علوم پزشکی زابل، زابل، ایران
Keihan
Fathi
کیهان
فتحی
3900319475328460070257
3900319475328460070257
No
Assistant Professor, ACER Khoozestan, Ahvaz, Iran
استادیار، گروه روان شناسی، موسسه جهاد دانشگاهی خوزستان، اهواز، ایران
Marya
Rahmani Ghobadi
ماریا
رحمانی قبادی
sportaag@yahoo.com
3900319475328460070258
3900319475328460070258
Yes
Asistant Professor in Exercise Physiology, Deportment of Physical Education and Sport Sciences, Damavand Branch, Islamic Azad University, Damavand, Iran
استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد دماوند، دانشگاه آزاد اسلامی، دماوند، ایران
Mahmood
Jafari
محمود
جعفری
3900319475328460070259
3900319475328460070259
No
PhD in Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Kharazmi University, Tehran, Iran
دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه خوارزمی، تهران، ایران
Motahareh
Moslehi
مطهره
مصلحی
3900319475328460070260
3900319475328460070260
No
Assistant Professor, Department of Physical Education, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
استادیار، گروه تربیت بدنی و علوم ورزشی، واحد اسلامشهر، دانشگاه آزاد اسلامی، اسلامشهر، ایران
Leila
Mafakher
لیلا
مفاخر
3900319475328460070261
3900319475328460070261
No
PhD in Sport Management, Department of Physical Education, Karoon Education, Karoon, Iran
دکتری مدیریت ورزشی، گروه تربیت بدنی، آموزش و پرورش کارون، کارون، ایران
Fatemeh
Zeighami
فاطمه
ضیغمی
3900319475328460070262
3900319475328460070262
No
MSc in Exercise Physiology, Department of Physical Education and Sports Science, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran
کارشناسی ارشد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران