Razi Journal of Medical Sciences

fa تاثیر مکمل کافئین - آب‌چغندر بر NTproBNP و IL-6 به دنبال یک دوره فعالیت هوازی در دوندگان حرفه‌ای استقامتی The Effect of Caffeine-Beet Supplementation on NTproBNP and IL-6 Following a Course of Aerobic Activity in Professional Endurance Runners فیزیولوژی ورزش Exercise Physiology پژوهشي Research زمینه و هدف: بررسی ویژگی‌های فیزیولوژیکی و شناخت عوامل‌پاتولوژیکی قلبی هنگام فعالیت‌های‌ورزشی‌استقامتی می‌تواند زمینه مناسبی را در شناسایی ورزشکارانی که در معرض خطر هستند، فراهم‌کند. هدف این پژوهش بررسی تاثیر مکمل کافئین-نیترات بر NTproBNP و IL-6 به دنبال یک دوره فعالیت هوازی در دوندگان حرفه‌ای‌استقامتی بود. روش‌کار: این مطالعه از نوع نیمه‌تجربی- میدانی آزمایشگاهی بود، 15دونده ‌نخبه ‌مرد با میانگین‌ سنی 8/3±5/27، میانگین ‌قد 7±7/176، میانگین ‌وزن 8/7±9/69 و شاخص ‌توده‌بدنی 5/1±3/22 و حداکثر اکسیژن ‌مصرفی (ml/kg/min) 6/4±2/52 انتخاب و به صورت سه سوکور و تصادفی، به سه گروه: ۱) دوز بالا (۹.۶میلی‌مول نیترات و ۴۰۰میلی‌گرم کافئین)، ۲) دوز پایین (۴.۸ و ۲۰۰) و ۳) دارونما تقسیم شدند. آزمودنی‌ها از هفت روز قبل از آزمون، روزانه دو بارمکمل را به همراه ۲۵۰سی‌سی  آب مصرف کردند. فعالیت ورزشی هوازی شامل دویدن روی تردمیل به مسافت 5 کیلومتر بود. یافته‌ها: نتایج نشان‌داد که مصرف مکمل تاثیر معناداری بر میزان NTproBNP (821/0p=) نداشته، ولی باعث کاهش IL-6 (001/0p=) شد. همچنین یک جلسه فعالیت ورزشی سبب افزایش معنی‌داری در سطح NTproBNP (05/0p<) و IL-6 (05/0p<) شده و مصرف مکمل بعد از هفت روز سبب کاهش سطح NTproBNP (071/0p=) و IL-6 (092/0p=)  به دنبال فعالیت ورزشی شد. نتیجه‌گیری: افزایش معنی‌دار مقادیر NTproBNP و IL-6 بلافاصله بعد از فعالیت و کاهش معنی‌دار آن‌ها بعد از هفت روز همراه با مصرف مکمل کافئین-نیترات، نشان دهنده این بود که استفاده از مکمل کافئین-نیترات  باعث بهبود اختلال قلبی ناشی از فعالیت ورزشی شدید می‌شود.   <div> <table align="left" hspace="0" vspace="0"> <tbody> <tr> <td align="left" style="padding-top:0in; padding-right:12px; padding-bottom:0in; padding-left:12px" valign="top">Background & Aims: The study of physiological characteristics and recognition of cardiac pathological factors during exercise and endurance activities can provide a good background in identifying athletes who are at risk. NTproBNP has been reported as a biological marker for the diagnosis of heart failure and disease progression in response to increased stress on the heart wall, increased volume, ventricular and atrial pressure, and other conditions such as ischemia or myocardial infarction and in response to various signals Increased myocardial infarction On the other hand, several studies have shown that elevated cytokines, particularly IL-6, severely modulate cardiac function and can lead to myocyte damage. Increased plasma IL-6 levels during exercise are associated with left ventricular dysfunction and are an important factor in the development of heart failure. It was a professional profession. Methods: The method of this research is laboratory, cross-sectional, laboratory, cross-sectional, and three-blind, by randomly selecting professional runners with the aim of investigating the effect of caffeine and beet juice supplementation on nitrate on NTproBNP and IL-6 followed by a The course of aerobic activity was performed in professional endurance runners. 15 elite male runners with a mean age of 27.5 3 3.8, mean height of 176.7 7 7.7, mean weight of 69.9 7 7.8 and body mass index of 22.3 1 1.5 and maximum oxygen consumption (ml / kg / min) Select 5.2 4 4.6 and randomly, into three groups: 1) High dose (9.6 mmol nitrate and 400 mg caffeine), 2) Low dose (4.8 and 200) and 3) Placebos were divided. Subjects consumed the supplement twice daily with 250 cc of water for seven days before the test. Aerobic exercise included running on a treadmill for 5 km. Plasma concentration of NTproBNP was measured in picograms per ml (pg / ml) and by electrochemiluminescence immunoassay (Elecsys NTproBNP 2010) with a sensitivity of 125 pg / ml. Plasma IL-6 was measured by BMS213HS kit with a sensitivity of 0.02 pg / ml and the results were shown in picograms per ml. Beet powder in powder form Beet powder Sun Say extract completely herbal and organic without sugar, gluten and other preservatives and synthetic chemicals and license made 10645/14 and caffeine in powder form made by Karen company and natural beet juice placebo It was examined by a food quality control laboratory and determined as a placebo with a little basic nitrate. The supplements were combined in three forms by the researcher's colleague in water and provided to the researcher as a solution for consumption. Random help supplement: 1) 9.6 mmol beet extract and 400 mg caffeine for high dose group, 2) 4.8 mmol beet extract and 200 mg caffeine for low dose group and 3) placebo water Natural beets were obtained for the placebo group. Results: The results showed that supplementation had no significant effect on NTproBNP (p = 0.821), but decreased IL-6 (p = 0.001). Also, one session of exercise significantly increased the levels of NTproBNP (p <0.05) and IL-6 (p <0.05) and supplementation after seven days decreased the levels of NTproBNP (p = 0.071) and IL-6 (p = 0.092) followed by sports activities. Conclusion: Considering the increase in plasma levels of NTproBNP and IL-6 immediately after exercise intervention and their significant decrease seven days after intervention, it can be said that due to doubts about the increase in these parameters after exercise, an activity with such a temporal and intense nature does not seem to lead to harm. However, the greater intensity in competitions and the effect of repetition of this training pattern in the long run cannot be ignored and it is suggested that in addition to interpreting the study results of plasma levels of NTproBNP and IL-6 in athletes, comprehensive cardiological studies and physiological factors affect Examine the secretion of these markers in other endurance sports activities for more accurate information on the physiological function of athletes' hearts during endurance sports activities. Also, due to the lack of significant effect of caffeine nitrate supplement on NTproBNP and significant reduction of this supplement on IL-6 after intense and short anaerobic exercise, it is not possible to be confident about taking caffeine-nitrate supplement to control inflammatory factors after intense anaerobic exercise. Commented; However, taking this supplement, due to its anti-oxidant properties and findings based on previous studies, will probably be somewhat beneficial for athletes who train hard. It may need to be used for a longer period of time to be more effective, and more studies are needed to find out more about the anti-inflammatory effects of caffeine-nitrate supplementation in humans. The limitations of this study were low number of samples, duration of sports intervention, lack of control over mental states and motivation of the subjects. Also, although the subjects were given a 24-hour reminder form, it was not possible to precisely control their feeding. In general, according to the findings of the present study and regardless of its limitations and considering the precautionary aspects, it can be recommended to young athletes that they can use caffeine-nitrate supplement to modulate cardiovascular risk factors. </td> </tr> </tbody> </table> </div> کافئین-آب چغندر, فعالیت ورزشی, قلبی عروق, دوندگان استقامتی Caffeine-Beet Supplementation,Aerobic Activity,Cardiovascular,Endurance Runners 102 116 http://rjms.iums.ac.ir/browse.php?a_code=A-10-4969-2&slc_lang=fa&sid=1 Maziyar Azizi مازیار عزیزی سعادتلو 3900319475328460064788 3900319475328460064788 No PhD student, Department of Sports Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran دانشجوی دکتری، گروه فیزیولوژی ورزشی، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران Ahmad Abdi احمد عبدی a.abdi58@gmail.com 3900319475328460064787 3900319475328460064787 Yes Associate Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran دانشیار، گروه فیزیولوژی ورزش، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران Javad Mehrebani جواد مهربانی 3900319475328460064789 3900319475328460064789 No Associate Professor, Department of Exercise Physiology, Gilan Univercity, Rasht, Iran دانشیار، گروه فیزولوژی ورزش، دانشگاه گیلان، رشت، ایران Asiyeh Abbasi deloyi آسیه عباسی دلویی 3900319475328460064790 3900319475328460064790 No Associate Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran دانشیار، گروه فیزیولوژی ورزش، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران