fa جوان‌سازی پوست با استفاده از فرآورده‌های حاوی پلاسمای غنی از پلاکت پوست Dermatology مروري review article <span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">از آنجایی که زیبایی و سلامت پوست، ازجمله شاخص‌های اصلی سلامت انسان بشمار می‌روند، راهکارهای مقابله با پیری پوست و روش‌های جوان‌سازی پوست از اهمیت ویژه‌ای برخوردارند. پیری پوست فرآیند بیولوژیکی پیچیده و اجتناب‌ناپذیری است که درنتیجه عوامل مختلف داخلی و خارجی همچون عوامل فیزیولوژیکی، رفتاری، جغرافیایی، محیطی و شیوه زندگی اتفاق می‌افتد و با تظاهرات بالینی همچون تغییرات ساختاری و فیزیولوژیکی، تغییرات پیگمانتاسیون، کاهش الاستیسیته و افزایش چین و چروک در پوست همراه است. امروزه با توجه به رشد روند سالمندی در جهان، تقاضا برای فرآورده‌های جوان‌سازی پوست با هدف محافظت از پوست در مقابل آسیب‌های ناشی از عوامل زیان‌آور خارجی یا داخلی، تامین مواد مغذی موردنیاز پوست، فعال سازی فیبروبلاست‌ها و حذف رادیکال‌های آزاد افزایش چشمگیری یافته است. </span></span></span><br> <span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">پلاسمای غنی از پلاکت یا (</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">) </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">Platelet Rich Plasma</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">، یک فرآورده بیولوژیکی است که از خون کامل تازه بدست می‌آید و به عنوان حاملی برای آزادسازی فاکتورهای رشد و سیتوکین با توانایی افزایش تولید کلاژن و کنترل آسیب اکسیداتیو در نظر گرفته می‌شود. این امرسبب شده است که کاربرد موضعی یا تزریق مستقیم فرآورده‌های </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;"> به داخل درم، بعنوان یکی از ساده‌ترین مداخلات بیولوژیکی در حوزه طب ترمیمی و درمان‌های زیبایی محسوب گردند. زیست سازگاری، فراهمی زیستی و اثربخشی بالینی بالا، عوارض جانبی کم، سهولت استفاده، غیرتهاجمی بودن و پذیرش و رضایت بالای مصرف کنندگان، برخی از مزایای درمان‌های مبتنی بر فرآورده‌های </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;"> می‌باشند. با این حال اختصاصی سازی فرمولاسیون‌های</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">، برای دستیابی به کارآیی، ایمنی، تحمل پذیری و پایداری بهینه فرآورده‌‌ها در شرایط مختلف بالینی چالشی مهم می‌باشد.</span></span></span><br> <span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">این مقاله به طور خلاصه به مفاهیم سلامت و زیبایی پوست، پیری پوست و تظاهرات بالینی آن، طبقه بندی پیری پوست با توجه به عوامل ایجاد کننده آن، راهکارهای جوان‌سازی پوست، مکانیسم عمل فاکتورهای رشد و پلاسمای غنی از پلاکت در جوان‌سازی پوست ، فواید درمان‌های مبتنی بر فرآورده‌های </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;">، روش تهیه و عوامل موثر بر کیفیت فرآورده‌های </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PRP</span></span></span></span><span style="color:black;"><span style="font-family:B Mitra;"><span style="font-size:10.0pt;"> و چالش‌های فرمولاسیون آن‌ها می‌پردازد.</span></span></span> The concepts of Skin health and beauty, which are as ancient as mankind and civilization, are considered as the main factors of human health and well-being. Therefore skin anti-aging strategies as well as skin rejuvenation methods that prevent, delay, repair and combat skin aging and eliminate its symptoms and maintain the structural and functional integrity of the skin, are of particular importance.<br> Skin aging is a complex and unpreventable biological process that occurs as a result of both intrinsic and extrinsic factors such as physiological, behavioral, geographical, and environmental and lifestyle factors. This dynamic and multifactorial process results from the formation and accumulation of reactive oxygen species (ROS) and the induction of matrix metalloproteinases. Skin aging is characterized by a progressive deterioration of the skin&#39;s functional properties, linked to alterations in dermal connective tissue due to the changes at the cell, gene and protein levels. Different physiological and pathological processes involved in skin aging, are accompanied by clinical manifestations such as cumulative structural and physiological changes in skin structure and appearance, pigmentation changes, reduced elasticity, and increased wrinkles in the skin.<br> Considering the increasing trend of aging in the world, and the growing interest to maintain a youthful appearance, the demand for skin rejuvenation practices has greatly increased to improve the quality of life (QOL), self-esteem, and improved body image among aging population.<br> The skin rejuvenation process uses a combination of different methods of bio-revitalization and techniques for repairing and strengthening different layers of the skin, along with changes in some other factors such as lifestyle, emotional and health status in order to relieve the aging signs.<br> Platelet-rich plasma (PRP), derived from fresh whole blood, is a biological product which contains platelets concentrated above baseline level. Activated platelet cells can be considered as vehicles for growth factors (GFs) and cytokine delivery, which play a crucial role in up-regulation of collagen production and controlling oxidative damage. Besides, GFs reduce the signs of aging by modulating cell migration, proliferation, differentiation, angiogenesis and chemotaxis. They can also stimulate collagen synthesis, reverse the effects of collagenases, increase extracellular matrix accumulation, and promote endothelial and epithelial regeneration. This issue has caused PRP to be used in multiple clinical fields such as orthopedics, regenerative sport medicine, plastic surgery, dermatology and aesthetic medicine, gynecology, ophthalmology, and dentistry, with remarkable results. Skin rejuvenation, dermal augmentation, hair restoration, and acne scaring, are some of PRP dermatological indications.<br> Topical application or direct injection of PRP compositions into the dermis can be considered as one of the simplest biological interventions in the field of reconstructive medicine and aesthetic treatments because of their capability to function as vehicles for growth factors and cytokine delivery. GFs and cytokines have the potential to address skin aging through stimulation of cell regeneration. Different GFs including platelet-derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF), present in PRP, stimulate human dermal fibroblasts. In fact Topical application of PRP or its direct injection into the skin, augment dermal elasticity by stimulating the removal of photodamaged extracellular matrix and induces the synthesis of new collagen and other matrix components by dermal fibroblasts via various molecular mechanisms. The ability of PRP to stimulate hyaluronic acid synthesis is another possible reason for skin rejuvenation.<br> It should be noted that the topical application of Cosmeceutical formulations, containing biologically active ingredients, is preferable to invasive methods or systemic treatments. Because it is a safe, non-invasive, fast and simple procedure with the ability of topical delivery of active ingredient and direct impact on the desired location, fewer possible side effects and toxicities, and high user acceptability. Furthermore topically applied cosmeceutical preparations have advantages such as more solubility and spreadability, less drug degradation and enhanced bioavailability.<br> Biocompatibility and biosafety, high clinical efficacy, fewer side effects, ease of use, non-invasiveness and greater acceptance and satisfaction of consumers, easier legal requirements, minimal manipulation, access to different methods of preparation, the possibility of adding different compounds to their formulation, reduced recovery time and downtime for patients, better aesthetic outcome, having antimicrobial activity and regeneration effect are some of PRP therapy benefits. However customizing PRP formulations for different clinical situations is an important challenge and should be carefully considered to achieve optimal efficacy, safety, tolerability, and stability.<br> This article briefly discusses the concepts of skin health and beauty, skin aging and its clinical manifestations, classification of skin aging according to its causative factors, Skin rejuvenation strategies, mechanism actions of growth factors and platelet-rich plasma in skin rejuvenation, benefits of PRP therapies, Platelet preparation method, factors affecting the quality of PRP products, and formulation challenges. antibiotic resistance characteristics are determined and appropriate antibiotics are prescribed.<br> &nbsp; پلاسمای غنی از پلاکت, پیری پوست, جوان سازی, فاکتورهای رشد Platelet-rich plasma, skin Aging, rejuvenation, Growth factors 1 9 http://rjms.iums.ac.ir/browse.php?a_code=A-10-5387-1&slc_lang=fa&sid=1 Mojgan Pourmokhtar مژگان پورمختار mpourmokhtar@gmail.com 3900319475328460054681 3900319475328460054681 Yes High Institute for Research and Education in Transfusion Medicine, Tehran, Iran موسسه عالی آموزشی و پژوهشی طب انتقال خون، تهران، ایران Mahya Abedi محیا عابدی 3900319475328460054682 3900319475328460054682 No Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران، ایران