fa ارتباط بین سطح سرمی ویتامین D با شدت انسداد در بیماری‌های انسدادی مزمن ریه مراجعه کننده به بیمارستان رسول اکرم(ص) طی سال 90-1389 داخلی ریه Pulmonary Disease پژوهشي Research <p class="MsoNormal" dir="rtl" style="margin-bottom: 0.0001pt line-height: normal direction: rtl unicode-bidi: embed"><b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">زمینه و هدف</span></b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">: </span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">بیماری (</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>) (</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">Chronic obstructive pulmonary disease</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>) بیماری شایع و ناتوان کننده است و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="AR-SA" dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">عوامل موثر بر آن همیشه مورد توجه بوده است. هدف از این مطالعه تعیین میانگین سطح سرمی ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> در بیماران دچار بیماری‌ مزمن انسدادی راه‌های هوایی (</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>) مراجعه‌کننده به بیمارستان رسول اکرم(ص) تهران طی سال 90-1389 می‌باشد.<o:p /></span></p> <p class="MsoNormal" dir="rtl" style="margin-bottom: 0.0001pt line-height: normal direction: rtl unicode-bidi: embed"><b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">روش کا</span></b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">ر:<b> </b>این مطالعه، یک مطالعۀ مقطعی بود و 56 بیمار مبتلا به </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> پس از انجام اسپیرومتری و تأیید </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> وارد مطالعه شدند. در همگی بیماران سطح سرمی ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> <span lang="AR-SA">اندازه‌گیری شد و سپس میانگین سطح سرمی ویتامین </span></span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> در بیماران </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> که بر اساس طبقه‌بندی موسسه </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">GOLD</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> <span lang="AR-SA">(</span></span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">Global</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">Initiative on Obstructive Lung Disease</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>) به پنج دسته‌ی صفر، یک، دو، سه و چهار تقسیم می‌شدند،  اندازه‌گیری شد، در آنالیز داده‌ها از نرم‌افزار </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">SPSS vs. 18</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> استفاده شد.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="AR-SA" dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><o:p /></span></p> <p class="MsoNormal" dir="rtl" style="margin-bottom: 0.0001pt line-height: normal direction: rtl unicode-bidi: embed"><b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">یافته</span></b><b><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">‌</span></b><b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">ها</span></b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">:<b> </b></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">میانگین سنی بیماران 3/10</span><span lang="AR-SA" style="font-size: 10pt font-family: 'Times New Roman', serif">±</span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">1/68 سال بود. 6/78% بیماران را مردان تشکیل می‌دادند. در این مطالعه مشخص شد که 7/85% بیماران دارای کمبود ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> کمتر از </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">ng/dl</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>30 بودند. همچنین در این مطالعه، نشان داده شد که رابطۀ خطی و مستقیم بین سطح سرمی ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> و حجم </span><span dir="ltr"></span><span dir="ltr"></span><span lang="AR-SA" dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif"><span dir="ltr"></span><span dir="ltr"></span> </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">FEV₁</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>(</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">forced</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">Expiratory volume  in one second</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>)</span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"> وجود دارد (45/0</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">B=</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>، 03/0</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">p=</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span>).<o:p /></span></p> <p class="MsoNormal" dir="rtl" style="margin-bottom: 0.0001pt line-height: normal direction: rtl unicode-bidi: embed"><b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">نتیجه‌گیری</span></b><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'">:<b> </b>در این مطالعه نشان داده شد که کمبود ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> در بیماران </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">COPD</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> از شیوع بالایی برخوردار می‌باشد. لذا انجام تست‌های تشخیصی از لحاظ کمبود ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> و درمان به موقع این بیماران می‌تواند از بسیاری عوارض کمبود ویتامین </span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">D</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="font-size: 10pt font-family: 'B Mitra'"><span dir="rtl"></span><span dir="rtl"></span> در این بیماران جلوگیری کند.</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif"><o:p /></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt line-height: normal"><b><span style="font-size: 12pt font-family: 'Times New Roman', serif">Background</span></b><span style="font-size: 12pt font-family: 'Times New Roman', serif">: The aim of this study was to determine the mean of the serum level of vitamin D in chronic obstructive pulmonary disease (COPD) patients referred to Rasoul-E-Akram Hospital, Tehran, Iran in 2010-11.<o:p /></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt line-height: normal"><b><span style="font-size: 12pt font-family: 'Times New Roman', serif">Methods</span></b><span style="font-size: 12pt font-family: 'Times New Roman', serif">: In this sectional study 56 patients with COPD were recruited. The COPD condition was confirmed in these patients following spirometry. Serum vitamin D level of all patients was measured and categorized according to the 5 stages of 0,1,2,3, and 4 suggested by Global Initiative on Obstructive Lung Disease (GOLD). The data were analyzed using SPSS v. 18.<o:p /></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt line-height: normal"><b><span style="font-size: 12pt font-family: 'Times New Roman', serif">Results</span></b><span style="font-size: 12pt font-family: 'Times New Roman', serif">: The mean age of patients was 68.1 ± 10.3. About%76 of patients were men. The study indicated that%85.1 of the patients were suffering from vitamin D deficiency with the level less than 30 mg /dl. Also, it was indicated that there is a direct and linear relation between serum vitamin D level and forced expiratory volume in one second (FEV1) volume(p= 0.03), (B= 0.4).<o:p /></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt line-height: normal"><b><span style="font-size: 12pt font-family: 'Times New Roman', serif">Conclusion</span></b><span style="font-size: 12pt font-family: 'Times New Roman', serif">: The study demonstrated that vitamin D deficiency in COPD patients is highly prevalent. Thus, diagnostic examinations of vitamin D deficiency and on time treatment can prevent from many related problems in these patients.<o:p /></span></p> سطح سرمی ویتامین D, بیماری‌ انسدادی مزمن ریه, اسپیرومتری Serum vitamin D level, COPD, Spirometry 35 40 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1679&slc_lang=fa&sid=1 هادی شهراد بجستانی 3900319475328460030026 3900319475328460030026 No سیدعلی جواد موسوی 3900319475328460030027 3900319475328460030027 No سیده زهرا رضایی szrezae@yahoo.com 3900319475328460030028 3900319475328460030028 Yes مریم حداد زاده شوشتری 3900319475328460030029 3900319475328460030029 No محسن عربی 3900319475328460030030 3900319475328460030030 No بیمارستان تامین اجتماعی شوشتر