Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1394
2
1
gregorian
2015
5
1
22
131
online
1
fulltext
fa
بررسی اثر عصاره ی اتانولی صمغ گیاه آنغوزه بر رگ زایی در پرده کوریوآلانتوئیک جنین جوجه
Investigating the effect of ethanolic extract of Ferula assa-foetida's resin on angiogenesis in chick chorioalantoic membrane
بیولوژی (زیست شناسی)
Biology
پژوهشي
Research
<p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal mso-layout-grid-align: none" dir="rtl"><font face="tahoma,arial,helvetica,sans-serif"><span lang="FA" style="color: black font-family: ">زمینه و هدف</span><span lang="FA" style="color: black font-family: ">:</span><span lang="FA" style="color: black font-family: "> </span><span lang="AR-SA" style="color: black font-family: ">مهار رگزایی هدف اصلی
درمان سرطان و برخی بیماریها میباشد.</span><span lang="FA" style="color: black font-family: "> آنغوزه یک</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">گیاه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">دارویی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">با</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">اثرات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">سیتوتوکسیک</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">است.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">هدف اصلی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">این</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">پژوهش
بررسی اثرات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">ضد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">رگزایی صمغ</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">آنغوزه میباشد.<o:p /></span></font></p><font face="Times New Roman" size="3"> ر</font><span lang="FA" style="color: black font-family: ">وش کار:</span><span lang="FA" style="color: black font-family: "> </span><span lang="FA" style="color: black font-family: ">40 عدد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">تخم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">مرغ</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">نطفهدار</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">نژاد</span><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
Hy-line </span><span lang="FA" style="color: black font-family: ">بهطور</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">تصادفی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">به 4 گروه: شاهد سالم، شاهد
آزمایشگاهی، تجربی 1 (تیمار با غلظت </span><span style="color: black font-family: " dir="ltr">μg/ml</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span> 100 عصاره) و تجربی 2 (تیمار
با غلظت </span><span style="color: black font-family: " dir="ltr">μg/ml</span><span dir="rtl"></span><span dir="rtl"></span><span style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA"><font face="B Lotus" size="3">200 عصاره)
تقسیم شدند. در</font></span></span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">روز</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">هشتم انکوباسیون در انتهای
پهن تخم مرغها پنجرهای باز شد و روی پرده</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">کوریوآلانتوئیک
اسفنج ژلاتینی قرار داده شد. به گروههای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">تیمار 10
میکرولیتر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">عصاره
آنغوزه، به</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">گروه
شاهد 10 میکرولیتر آب مقطر و به گروه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">شاهد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">آزمایشگاهی 10 میکرولیتر
حلال</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">دی</span><span style="color: black font-family: " dir="ltr"></span><span lang="FA" style="color: black font-family: ">متیل</span><span style="color: black font-family: " dir="ltr"></span><span lang="FA" style="color: black font-family: ">سولفوکساید</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">تزریق شد.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">روز</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">دوازدهم انکوباسیون</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">از</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">عروق</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">تمام</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">نمونهها</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">عکس</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">برداری</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">شد و مجموع طول و تعداد
عروق خونی در اطراف محل تیمار</span><span lang="FA" style="color: black font-family: "> </span><span lang="AR-SA" style="color: black font-family: ">توسط </span><span lang="FA" style="color: black font-family: ">آنالیز واریانس یکطرفه (</span><span style="color: black font-family: " dir="ltr">ANOVA</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span>) و آزمون تعقیبی </span><span style="color: black font-family: " dir="ltr">Tukey</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span> در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">سطح 05/0</span><span style="color: black font-family: " dir="ltr">p<</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span> تحلیل</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">شد.<o:p /></span><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal mso-layout-grid-align: none" dir="rtl"><span lang="FA" style="color: black font-family: ">یافتهها:</span><b><span lang="FA" style="color: black font-family: "> </span></b><span lang="FA" style="color: black font-family: ">میانگین</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">تعداد و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">مجموع طول انشعابات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">عروقی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">گروه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">شاهد
آزمایشگاهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">در
مقایسه با</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">تعداد و
مجموع</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">طول
انشعابات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">عروقی در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">گروه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">شاهد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">اختلاف</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">معنی</span><span style="color: black font-family: " dir="ltr"></span><span lang="FA" style="color: black font-family: ">داری نشان</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">نداد.
میانگین</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">تعداد و
مجموع</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">طول
انشعابات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">عروقی در
غلظتهای 100 و 200 میکروگرم بر میلیلیتر عصاره اتانولی صمغ آنغوزه در مقایسه با
گروه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">شاهد
کاهش</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">معنی</span><span style="color: black font-family: " dir="ltr"></span><span lang="FA" style="color: black font-family: ">داری</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">نشان</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">داد (05/0</span><span style="color: black font-family: " dir="ltr">p<</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "><span dir="rtl"></span><span dir="rtl"></span>).</span><b><span lang="FA" style="color: black font-family: "><o:p /></span></b></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal mso-layout-grid-align: none" dir="rtl"><span lang="FA" style="color: black font-family: ">نتیجهگیری:</span><b><span lang="FA" style="color: black font-family: "> </span></b><span lang="FA" style="color: black font-family: ">عصاره</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">اتانولی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">صمغ آنغوزه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">مطابق</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">با</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">روشهای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">این</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">پژوهش</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">اثر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">مهاری</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">بر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">رگزایی
در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">پرده
کوریوآلانتوئیک</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">جنین</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">جوجه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="color: black font-family: ">دارد. بهنظر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: " dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="color: black font-family: ">میرسد از ترکیبات موجود در
صمغ آنغوزه میتوان جهت مهار رگزایی در بافتهای سرطانی استفاده کرد. </span><b><span lang="FA" style="color: black font-family: "><o:p /></span></b></p><font face="Times New Roman" size="3"> </font>
<p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: ltr mso-layout-grid-align: none tab-stops: 22.85pt center 234.0pt"><b><span style="color: black font-family: ">Background:</span></b><b><span style="color: black font-family: "> </span></b><span class="hps"><span lang="EN" style="color: black font-family: ">Inhibition of</span></span><span lang="EN" style="color: black font-family: "> <font size="2"><font face="Times New Roman"><span class="hps">angiogenesis</span> <span class="hps">is
the</span> <span class="hps">main goal of</span> <span class="hps">cancer treatment
and other</span> <span class="hps">diseases</span>. </font></font></span><i><span style="color: black font-family: "><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font face="Times New Roman" size="2">Ferula
assa-foetida</font></u></span></a></span></i><span style="color: black font-family: "> i<font size="2"><font face="Times New Roman"><span class="hps">s</span><span class="longtext"> </span><span class="hps">a</span><span class="longtext"> </span><span class="hps">medicinal plant</span><span class="longtext"> </span><span class="hps">with</span><span class="longtext"> </span><span class="hps">cytotoxic effects</span><span class="longtext">.</span></font></font></span><span style="color: black font-family: "> </span><span style="color: black font-family: ">The aim of this study was to
investigate the </span><span class="hps"><span lang="EN" style="color: black font-family: ">anti-angiogenic
effects</span></span><span lang="EN" style="color: black font-family: "> <span class="hps"><font face="Times New Roman" size="2">of</font></span></span><span lang="EN" style="color: black font-family: "> </span><i><span style="color: black font-family: "><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font face="Times New Roman" size="2">Ferula
assa-foetida</font></u></span></a></span></i><span style="color: black font-family: ">'s resin. <o:p /></span></p><font face="Times New Roman" size="3"> </font><span class="hps"><b><span style="color: black font-family: ">Methods</span></b></span><b><span style="color: black font-family: ">:</span></b><span style="color: black font-family: "> 40
Hy-line fertilized eggs were divided into 4 groups: control, sham, </span><span class="hps"><span lang="EN" style="color: black font-family: ">experimental 1</span></span><span style="color: black font-family: "> (</span><span class="hps"><span lang="EN" style="color: black font-family: ">treated</span></span><span lang="EN" style="color: black font-family: "> <font face="Times New Roman"><font size="2"><span class="hps">with</span> <span class="hps">100 </span></font></font></span><span style="color: black font-family: ">μg/ml</span><span style="color: black font-family: "> <span class="hps"><span lang="EN"><font face="Times New Roman" size="2">of </font></span></span></span><span style="color: black font-family: ">extract), </span><span class="hps"><span lang="EN" style="color: black font-family: ">experimental 2</span></span><span style="color: black font-family: "> (</span><span class="hps"><span lang="EN" style="color: black font-family: ">treated</span></span><span lang="EN" style="color: black font-family: "> </span><span style="color: black font-family: ">with</span><span style="color: black font-family: "> <span class="hps"><span lang="EN"><font face="Times New Roman" size="2">200 </font></span></span></span><span style="color: black font-family: ">μg/ml</span><span style="color: black font-family: "> <span class="hps"><span lang="EN"><font face="Times New Roman" size="2">of </font></span></span></span><span style="color: black font-family: ">extract). On the eighth day of incubation it <span class="hps"><font face="Times New Roman" size="2">was </font></span></span><span class="hps"><span lang="EN" style="color: black font-family: ">created a window in</span></span><span class="shorttext"><span lang="EN" style="color: black font-family: "> </span></span><span class="hps"><span lang="EN" style="color: black font-family: ">the bottom of</span></span><span class="shorttext"><span lang="EN" style="color: black font-family: "> </span></span><span class="hps"><span lang="EN" style="color: black font-family: ">the eggs</span></span><span style="color: black font-family: "> and gelatin sponge was
placed on chorioallantoic membrane. 10 microliters of</span><span class="hps"><span style="color: black font-family: "> </span></span><i><span style="color: black font-family: "><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font face="Times New Roman" size="2">Ferula
assa-foetida</font></u></span></a></span></i><span style="color: black font-family: ">'s resin</span><span class="hps"><span lang="EN" style="color: black font-family: "> extract was injected</span></span><span style="color: black font-family: "> to
treated groups. 10 microliters of</span><span class="hps"><span lang="EN" style="color: black font-family: "> distilled water</span></span><span lang="EN" style="color: black font-family: "> </span><span class="hps"><span lang="EN" style="color: black font-family: ">was injected</span></span><span style="color: black font-family: "> to
control group and 10 microliters of </span><span style="color: black font-family: ">dimethyl sulfoxide</span><span class="MsoCommentReference"><span style="color: black font-size: 10pt"><font face="Calibri"> </font></span></span><span class="hps"><span lang="EN" style="color: black font-family: ">was injected</span></span><span style="color: black font-family: "> to
sham-exposed group. All samples were photographed on the 12th day of incubation
and the length and numbers of vessels were analyzed by ANOVA and Tukey’s<font size="2"><font face="Times New Roman"><span class="st"> post hoc</span> <span class="longtext">(p<span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span>></span></span><span dir="ltr"></span><span dir="ltr"></span><em><span style="font-style: normal"><span dir="ltr"></span><span dir="ltr"></span>0.05)<span dir="rtl"></span><span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> </span></span></em></font></font></span><span style="color: black font-family: Times-Roman font-size: 10pt mso-bidi-font-family: Times-Roman"><o:p /></span><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: ltr"><span class="hps"><b><span style="color: black font-family: ">Results</span></b></span><b><span style="color: black font-family: ">: </span></b><span style="color: black font-family: ">The mean of number and length for
vessels in the control group and mean of number and length in sham-exposed
group was not significant. There was a significant decrease in mean number and
length of vessels <font size="2"><font face="Times New Roman"><span class="hps">at</span><span class="longtext"> </span><span class="hps">concentration of 100 and 200</span><span class="longtext"> </span></font></font></span><span style="color: black font-family: ">μg/ml<span class="hps"><font face="Times New Roman" size="2"> of</font></span></span><span class="longtext"><span style="color: black font-family: "> </span></span><i><span style="color: black font-family: "><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font face="Times New Roman" size="2">Ferula
assa-foetida</font></u></span></a></span></i><span style="color: black font-family: ">'s resin</span><span style="color: black font-family: "> <span class="hps"><font face="Times New Roman" size="2">extract </font></span></span><span class="hps"><span lang="EN" style="color: black font-family: ">compared </span></span><span style="color: black font-family: ">with control group.<o:p /></span></p><font face="Times New Roman"><font size="3"> </font><span class="hps"><b><span style="color: black line-height: 115% font-family: ">Conclusion</span></b></span><b><span style="color: black line-height: 115% font-family: ">: </span></b><span class="hps"><span lang="EN" style="color: black line-height: 115% font-family: ">According
to</span></span><span class="longtext"><span lang="EN" style="color: black line-height: 115% font-family: "> </span></span><span class="hps"><span lang="EN" style="color: black line-height: 115% font-family: ">this research,</span></span><span class="longtext"><span lang="EN" style="color: black line-height: 115% font-family: "> </span></span><span style="color: black line-height: 115% font-family: ">ethanolic</span><span style="color: black line-height: 115% font-family: "> extract of <i><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font size="2">Ferula
assa-foetida</font></u></span></a></i>'s resin has an inhibitory effect on angiogenesis in
chick chorioalantoic membrane.</span><span style="color: black line-height: 115% font-family: "> <font size="2"><span class="hps"><span lang="EN">It seems</span></span><span lang="EN"> <span class="hps">that</span> <span class="hps">compounds</span> <span class="hps">of </span></span></font></span><i><span style="color: black line-height: 115% font-family: "><a href="http://www.google.com/search?q=ferula+assafoetida&hl=en&prmd=imvns&tbm=isch&tbo=u&source=univ&sa=X&ei=LkEAUNC2IpP54QSpsMmeCA&ved=0CF0QsAQ&biw=1024&bih=661"><span style="color: black text-decoration: none text-underline: none"><u><font size="2">Ferula
assa-foetida</font></u></span></a></span></i><span style="color: black line-height: 115% font-family: ">'s resin</span><span style="color: black line-height: 115% font-family: "> <font size="2"><span class="hps"><span lang="EN">can</span></span><span lang="EN"> <span class="hps">be used</span>
<span class="hps">to inhibit</span> <span class="hps">angiogenesis</span> <span class="hps">in</span> <span class="hps">cancer</span> <span class="hps">tissues</span></span></font></span></font>
رگ زایی, صمغ آنغوزه, پرده کوریوآلانتوئیک, جنین جوجه
Angiogenesis, Resin of Ferula assa-foetida, Chorioalantoic Membrane, Chick Embryo
80
87
http://rjms.iums.ac.ir/browse.php?a_code=A-10-1854-2&slc_lang=fa&sid=1
Seyed Damoon
Sadoughi
سیددامون
صدوقی
damoon.sadughi@Gmail.com
3900319475328460029370
3900319475328460029370
Yes
Islamic Azad University, Mashhad, Iran
دانشگاه آزاد اسلامی، واحد مشهد،مشهد، ایران
Saide
Zafar-Balanezhad
سعیده
ظفربالانژاد
Mojgan_zafar@yahoo.com
3900319475328460029371
3900319475328460029371
No
Islamic Azad University, Mashhad, Iran.
دانشگاه آزاد اسلامی، واحد مشهد،مشهد، ایران
Javad
Baharara
جواد
بهارآرا
Baharara@yahoo.com
3900319475328460029372
3900319475328460029372
No
Islamic Azad University, Mashhad, Iran.
دانشگاه آزاد اسلامی، واحد مشهد،مشهد، ایران
Khadijeh
Nejhad Shahrokhabadi
خدیجه
نژادشاهرخ آبادی
Shahrokhabay@yahoo.com
3900319475328460029373
3900319475328460029373
No
Islamic Azad University, Mashhad, Iran
دانشگاه آزاد اسلامی، واحد مشهد،مشهد، ایران
Raheleh
Rahbarian
راهله
رهباریان
Ra_rahbarian@yahoo.com
3900319475328460029374
3900319475328460029374
No
Sciences Faculty, Payam-e-Noor University, Tehran, Iran
دانشگاه پیام نور، تهران، ایران
Heshmat
Sepehri-Moghadam
حشمت
سپهری مقدم
Sepehri.h@pnurazavi.ac.ir
3900319475328460029375
3900319475328460029375
No
Payam-e-Noor University, Tehran, Iran
دانشگاه پیام نور، تهران، ایران