fa تاثیر هشت هفته تمرین هوازی بر عوامل خطرزای هورمونی و قلبی-عروقی زنان مبتلا به سرطان سینه فیزیولوژی ورزش Exercise Physiology پژوهشي Research <font face="Times New Roman" size="3"> </font><p class="MsoNoSpacing" style="margin: 0cm -0.05pt 0pt 0cm text-align: justify line-height: 115% mso-pagination: none" dir="rtl"><b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt">زمینه وهدف:</span></b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt"> افزایش و کاهش برخی از هورمون­ها در بدن و تجمع آن در بافت سینه، خطر ابتلا به سرطان سینه را بالا می­برد. </span><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">هدف از پژوهش حاضر، تاثیر هشت هفته تمرین هوازی بر گلوبولین متصل به هورمون جنسی، هورمون رشد شبه انسولین-1 و لیپوپروتئین­های سرم بیماران مبتلا به سرطان سینه بود. </span><span lang="FA" style="color: black font-family: "Times New Roman","serif" mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt text-align: justify line-height: 115% mso-pagination: none" dir="rtl"><b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">روش کار</span></b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">: 24 زن 45-55 سال مبتلا به سرطان سینه انتخاب و به­طور تصادفی به دو گروه هوازی (12</span><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt">=</span><font face="Calibri"><span style="color: black line-height: 115% font-size: 12pt mso-bidi-font-family: "B Nazanin"" dir="ltr">n</span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span>) و کنترل (12</span><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt">=</span><font face="Calibri"><span style="color: black line-height: 115% font-size: 12pt mso-bidi-font-family: "B Nazanin"" dir="ltr">n</span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span>) تقسیم شدند. آزمودنی­های گروه­ تمرینی به­مدت 8 هفته، 3 روز در هفته و به­مدت 60-90 دقیقه در روز به فعالیت ورزشی پرداختند. در این مدت، گروه کنترل هیچ­گونه فعالیت ورزشی منظم نداشتند. قبل و بعد از هشت هفته، از کلیه آزمودنی­ها نمونه­گیری خونی انجام شد. با استفاده از روش آزمون تحلیل واریانس یک­طرفه، تجزیه و تحلیل آماری داده­ها انجام گرفت و در صورت معنی­دار بودن، از آزمون تعقیبی توکی برای تعیین محل اختلاف استفاده شد.<b><o:p /></b></span></p><font face="Times New Roman" size="3"> </font><h3 style="background: white margin: 0cm 0cm 0pt text-align: justify" dir="rtl"><font style="background-color: rgb(255, 255, 255)"><font><font><font><font><font><font><font><font><font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-fareast-font-family: Calibri mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">یافته­ها</span><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-fareast-font-family: Calibri mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">: نتایج نشان داد که تفاوت معنی­داری بین میزان گلوبولین متصل به هورمون</span><span lang="FA" style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-fareast-font-family: Calibri">‌</span><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-fareast-font-family: Calibri mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">های جنسی زنان </span><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-bidi-font-family: "B Nazanin"" dir="ltr">SHBG</span><span dir="rtl"></span><span dir="rtl"></span></font></font><span style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-fareast-font-family: Calibri mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span><font> </font><span lang="FA"><font face="B Nazanin" size="3">(</font></span></span><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-fareast-font-family: Calibri mso-bidi-font-family: "B Nazanin""><a href="http://en.wikipedia.org/wiki/Sex_hormone-binding_globulin"><span style="color: black text-decoration: none mso-fareast-font-family: "Times New Roman" text-underline: none" dir="ltr"><u><font face="Times New Roman" size="3">Sex hormone-binding globulin</font></u></span></a></span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span>)، </span></font><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-bidi-font-family: "B Nazanin"" dir="ltr">LDL</span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span> (</span></font><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-bidi-font-family: "B Nazanin""><a href="http://en.wikipedia.org/wiki/Low-density_lipoprotein"><span style="color: black text-decoration: none text-underline: none" dir="ltr"><u><font face="Times New Roman" size="3">Low-density lipoprotein</font></u></span></a></span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span>) و کلسترول تام در قبل و بعد از هشت هفته فعالیت هوازی مشاهده می­شود. همچنین فعالیت ورزشی موجب کاهش معنی­دار وزن (001/0</span></font><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt font-weight: normal mso-bidi-font-family: "B Nazanin"" dir="ltr">p=</span><span dir="rtl"></span><span dir="rtl"></span></font><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt font-weight: normal mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""><span dir="rtl"></span><span dir="rtl"></span>) در آزمودنی­های گروه تمرین نسبت به گروه کنترل شد. <o:p /></span></font></h3><font face="Times New Roman" size="3"> </font><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt text-align: justify line-height: 115% mso-pagination: none" dir="rtl"><b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">نتیجه­گیری:</span></b><span lang="FA" style="color: black line-height: 115% font-family: "B Nazanin" font-size: 12pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""> نتایج تحقیق نشان می­دهد که فعالیت­های ورزشی هوازی بر سرطان سینه تاثیر مثبت دارد و می­تواند در کاهش عوارض این بیماران در کنار دارودرمانی و سایر مداخلات پزشکی کمک کنند.<b><o:p /></b></span></p><font face="Times New Roman" size="3"> </font> <font face="Times New Roman" size="3"> </font><p align="right" class="MsoNoSpacing" style="margin: 0cm -0.05pt 0pt 0cm text-align: left line-height: 115% mso-pagination: none" dir="rtl"><font face="Calibri"><b><span style="color: black line-height: 115% font-size: 12pt" dir="ltr">Background: </span></b><span class="hps"><span style="color: black line-height: 115% font-size: 12pt" dir="ltr">Increase</span></span><span style="color: black line-height: 115% font-size: 12pt" dir="ltr"> <font size="3"><span class="hps">and</span> <span class="hps">decrease of</span> <span class="hps">some hormones</span> <span class="hps">in the body</span> <span class="hps">and accumulation</span> <span class="hps">in</span> <span class="hps">breast tissue</span>, <span class="hps">can increase the risk of breast cancer</span>. <span class="hps">The purpose of this study was to examine the effects of eight weeks aerobic training</span> <span class="hps">on</span> <span class="hps">the sexual hormone</span> <span class="hps">binding</span> <span class="hps">globulin</span>, <span class="hps">insulin-like growth</span> <span class="hps">hormone</span>-1 and <span class="hps">lipoproteins in</span> <span class="hps">patients with</span> <span class="hps">breast</span> <span class="hps">cancer.<o:p /></span></font></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: left unicode-bidi: embed direction: ltr"><font face="Calibri"><b><span style="color: black line-height: 115% font-size: 12pt">Methods: </span></b><span style="color: black line-height: 115% font-size: 12pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "Times New Roman"">Twenty four women aged 45-55 years with breast cancer were selected and randomly divided into two groups: aerobic training (n=12) and control (n=12). Training group participated in an 8 weeks aerobic training program, three days a week and 60-90 minutes each day. In this period, the control group performed no regular exercise. Blood samples were taken before and after 8 weeks. Data were analyzed using independent T- test.<o:p /></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: left unicode-bidi: embed direction: ltr"><font face="Calibri"><b><span style="color: black line-height: 115% font-size: 12pt">Results: </span></b><span style="color: black line-height: 115% font-size: 12pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "Times New Roman"">The results showed that there were significant differences between two groups in SHBG (</span></font><b><span style="color: black line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-family: "B Nazanin""><a href="http://en.wikipedia.org/wiki/Sex_hormone-binding_globulin"><span style="color: black font-weight: normal text-decoration: none text-underline: none"><u><font face="Times New Roman" size="3">Sex hormone-binding globulin</font></u></span></a>)</span></b><span style="color: black line-height: 115% font-size: 12pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "Times New Roman""><font face="Calibri">, LDL (Low-density lipoprotein) and total cholesterol prior and post eight weeks of aerobic exercise training. Exercise also significantly reduced exercise group’s weight (p=0.001) compared with the controls. <o:p /></font></span></p><font size="3"><font face="Times New Roman"> </font><b><span style="color: black line-height: 115% font-family: "Calibri","sans-serif" font-size: 12pt mso-bidi-language: FA mso-fareast-font-family: Calibri mso-bidi-font-family: Arial mso-ansi-language: EN-US mso-fareast-language: EN-US">Conclusion:</span></b><span style="color: black line-height: 115% font-family: "Calibri","sans-serif" font-size: 12pt mso-bidi-language: FA mso-fareast-font-family: Calibri mso-bidi-font-family: Arial mso-ansi-language: EN-US mso-fareast-language: EN-US"> It is concluded that aerobic exercise has a positive impact on breast cancer and can decrease its side effects and be helpful with medical service</span></font> گلوبولین متصل به هورمون جنسی, هورمون رشد شبه انسولین 1, فعالیت ورزشی, سرطان سینه Sexual hormones, binding globulin, Insulin-Like growth hormone- 1, Exercise, Breast cancer 35 43 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1726-3&slc_lang=fa&sid=1 Mohsen Salesi محسن ثالثی mhsnsls@gmail.com 3900319475328460029290 3900319475328460029290 No Shiraz University, Shiraz, Iran دانشگاه شیراز، شیراز، ایران Zahra Khoshneshin Ghashghaee زهرا خوش نشین قشقایی z_khgh@yahoo.com 3900319475328460029291 3900319475328460029291 Yes Shiraz, Iran موسسه آموزش عالی زند، شیراز، ایران Farhad Daryanoosh فرهاد دریانوش daryanoosh@shirazu.ac.ir 3900319475328460029292 3900319475328460029292 No Shiraz University, Shiraz, Iran دانشگاه شیراز، شیراز، ایران Sedigheh Tahmasebi صدیقه طهماسبی tahmasebikh@gmail.com 3900319475328460029293 3900319475328460029293 No Shiraz University of Medical Sciences, Shiraz, Iran دانشگاه علوم پزشکی شیراز، شیراز، ایران Abdolrasool Taleie عبدالرسول طالعی taleiar@gmail.com 3900319475328460029294 3900319475328460029294 No Shiraz University of Medical Sciences, Shiraz, Iran دانشگاه علوم پزشکی شیراز، شیراز، ایران