fa بررسی سطح سرمی هوموسیستئین در زنان باردار پرهاکلامپتیک و زنان باردار غیر پرهاکلامپتیک ترم در بیمارستان شهید اکبرآبادی تهران زنان و زایمان Gynecology پژوهشي Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">: </span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">هیپرهوموسیستئینمی در افزایش بروز مشکلات حین بارداری و زایمان نظیر پره</span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">‌</span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">اکلامپسی نقش دارد. مطالعه حاضر با هدف مقایسه سطح سرمی هوموسیستئین در زنان باردار ترم پره</span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">‌</span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">اکلامپتیک با غیر پره</span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">‌</span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">اکلامپتیک انجام گرفت.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">روش کار</span></b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">: مطالعه مورد شاهدی حاضر بر روی 50 نفر از زنان باردار ترم تک قلوی بالای 37 هفته طی سال‌های 1386-1384 انجام شده است. زنان بارداری که سابقه بیماری های نظیر فشار خون مزمن، دیابت، صرع و نیز مصرف داروهایی نظیر متوتروکسات، کاربامازپین و فنی توئین و سایر داروهای ضد تشنج را داشتند، از مطالعه خارج شدند. در صورت وجود پروتئینوری مساوی یا بالاتر از 300 میلی گرم در ادرار 24 ساعته و یا مساوی یا بالاتر از 1+ در آزمایش </span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN" dir="ltr">Dipstick</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN"><span dir="rtl"></span><span dir="rtl"></span>، به همراه فشار خون مساوی یا بالاتراز مقدار 90/140 میلی متر جیوه، خانم باردار در گروه مورد قرار می گرفت. در این مطالعه به ازای هر فرد از گروه مورد، یک نفر به عنوان گروه کنترل در نظر گرفته شد. در این مطالعه از آزمون </span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN" dir="ltr">student T-test</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN"><span dir="rtl"></span><span dir="rtl"></span> و مدل رگرسیون لجستیک در نرم افزار </span><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN" dir="ltr">SPSS</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN"><span dir="rtl"></span><span dir="rtl"></span> با سطح معنی داری 95% برای تجزیه و تحلیل داده ها استفاده شد.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">یافته</span></b><b><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN" dir="ltr">‌</span></b><b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">ها</span></b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">:</span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> در این مطالعه میانگین سطح سرمی هوموسیستئین در زنان باردار مبتلا به پره اکلامپسی به صورت معنی داری بالاتر از سایر زنان باردار بود.</span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">نتیجه</span></b><b><span style="color: black font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN" dir="ltr">‌</span></b><b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">گیری</span></b><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">: با توجه به نقش معنی دار </span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">هوموسیستئین </span><span lang="FA" style="color: black font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA mso-fareast-font-family: SimSun mso-fareast-language: ZH-CN">در بروز پره اکلامسی در زنان باردار، کنترل این ماده با استفاده از رژیم های غذایی و یا مصرف دارو توصیه می گردد.<o:p /></span></p><font face="Times New Roman" size="3"> </font> <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Background</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">: due to this fact that hyperhomocysteinemia had role in increasing incidence of pregnancy and delivery problems such as preeklampsia, it seems that performing present study for assessing serum level of homocysteine in pregnant women with preeklampsia was necessary. Present study was performed for comparing homocysteine level between term pregnant women with and without preeklampsia.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Methods</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">: Fifty term pregnant women with higher than 37 weeks gestational age between 2005 and 2007 were recruited. Pregnant women with history of chronic hypertension, diabetes, epilepsy and those using methotrexate, carbamazepine, phenytoin and other anticonvulsant drugs, were excluded. Pregnant women with more than 300 mg protein in 24-hours urine sample or +1 results with Dipstick test for proteinuria and blood pressure more than 140/90 mmhg were defined as case group. Equal and matched pregnant women were selected for control group. Independent student t-test and logistic regression model were used as statistical test. SPSS software was used for data analysis and p-values less than 0.05 were assumed as significant.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Results</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">: Mean of serum level of homocysteine in pregnant women with preeklampsia was significantly higher than other pregnant women.<o:p /></span></p><font size="3"><font face="Times New Roman"> <b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman" mso-fareast-theme-font: minor-fareast mso-fareast-language: EN-US mso-ansi-language: EN-US">Conclusion</span></b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman" mso-fareast-theme-font: minor-fareast mso-fareast-language: EN-US mso-ansi-language: EN-US">: According to the role of homocysteine in incidence of preeklampsia in pregnant women, prescribing drug and control of dietary regimen were recommended for control of serum level of homocysteine in pregnant women</span></font></font> بارداری, پره اکلامسی, هوموسیستئین Homocysteine, Preeclampsia, Pregnancy 51 57 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1648&slc_lang=fa&sid=1 Zahra Vaziri زهرا وزیری 3900319475328460028366 3900319475328460028366 No Iran University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی ایران، تهران، ایران Parvaneh Lak پروانه لک 3900319475328460028367 3900319475328460028367 Yes Iran University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی ایران، تهران، ایران Peymaneh Lak پیمانه لک 3900319475328460028368 3900319475328460028368 No Iran University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی ایران، تهران، ایران