Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1393
8
1
gregorian
2014
11
1
21
125
online
1
fulltext
fa
تاثیر تروگزروتین بر پراکسیداسیون لیپیدی و آسیب بافتی ناشی از آسیب ایسکمی- رپرفیوژن در قلب موش دیابتی
The effect of troxerutin on lipid peroxidation and tissue injury induced by myocardial ischemia reperfusion injury in diabetic rat
آموزش بهداشت
Educational Health
پژوهشي
Research
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">:
</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دیابت یکی از ریسک فاکتورهای اصلی بیماری
ایسکمیک قلبی می باشد. تروگزروتین</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (TXR)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، یک بیوفلاونوئید
طبیعی دارای ویژگیهای بیولوژیکی آنتی اکسیداتیو و ضدالتهاب می باشد. هدف مطالعه حاضر،
بررسی تداخل بیماری دیابت نوع یک با تاثیر محافظتی تروگزروتین بر پراکسیداسیون لیپیدی
و آسیب بافتی ناشی از آسیب ایسکمی-رپرقیوژن میوکارد موش صحرایی است</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">روش کار</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">: رتهای نر نژاد ویستار (300-250گرم) به 4 گروه کنترل، کنترل</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>+TXR</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، دیابت و دیابت</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>+TXR </span><span dir="rtl"></span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span><font size="2"><font face="B Mitra"><span style="mso-spacerun: yes"> </span><span lang="FA">تقسیم شدند. جهت ایجاد دیابت مزمن
(10هفته) از روش تزریق داخل صفاقی </span></font></font></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">mg/kg</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>
<span lang="FA"><font face="B Mitra" size="2">50 داروی استرپتوزوتوسین به صورت تک دوز استفاده شد. بعد از 6 هفته دیابتی
شدن، گروه های دریافت کننده</font></span></span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> TRX </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">از طریق گاواژ به مدت 4 هفته با</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">TXR</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>،
</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">mg/kg</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> 150 تیمار شدند.
قلب رتها ایزوله شده و سریعا</span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 10pt mso-ansi-font-size: 9.0pt mso-bidi-language: FA">̋</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> در روی دستگاه لانگندروف، 30دقیقه ایسکمی
ناحیه ای و 60دقیقه رپرفیوژن تجربه کردند. سطوح پراکسیداسیون لیپیدی</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
(MDA) </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">از سوپرناتانت بطن چپ و میزان کراتین کیناز</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (CK)
</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">از جریان کرونری با استفاده از کیت های اختصاصی
و روش اسپکتوفتومتری اندازه گیری گردید</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">یافتهها</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">: استرپتوزوتوسین باعث افزایش قند خون در گروه های دیابتی نسبت
به گروه کنترل شد. تروگزروتین توانست قند خون را در گروه دیابتی دریافت کننده</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> TXR </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">کاهش دهد اما این کاهش از لحاظ آماری معنی دار نبود. سطوح</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> MDA </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">در گروه دیابتی ایسکمی-رپرفیوژن شده نسبت به کنترل شدیدا</span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 10pt mso-ansi-font-size: 9.0pt mso-bidi-language: FA">̋</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">افزایش یافت و</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> TXR </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">توانست سطوح</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> MDA </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">را در گروه دیابتی کاهش دهد </span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>(p<0.05)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>. دیابت در قلب ایسکمی-رپرفیوژن شده، باعث آزادشدن مقادیر زیادی</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> CK </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نسبت به گروه کنترل شد. تجویز</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> TXR </span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">باعث کاهش سطح این آنزیم در گروه دیابتی شد</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نتیجه گیری</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">: تروگزروتین با جلوگیری از تشدید استرس اکسیداتیو و احتمالا</span><span lang="FA" style="font-family: "Times New Roman","serif" font-size: 10pt mso-ansi-font-size: 9.0pt mso-bidi-language: FA">̋</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> فعال سازی سیستم دفاعی آنتی اکسیداتیو، پراکسیداسیون
لیپیدی و آسیب بافتی را به ویژه در رتهای دیابتی کاهش داده و می تواند اثرات محافظتی
در آسیب قلبی ناشی از ایسکمی و رپرفیوژن داشته باشد</span><span dir="ltr"></span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-ansi-font-size: 9.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font>
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Background: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Diabetes
is a main risk factor of ischemic heart disease. Troxerutin, a natural
bioflavonoid rutin, has many biologic properties, such anti-oxidative and
anti-inflammatory effects. The purpose of this study was to investigate the
interaction of diabetes with the protective effect of troxerutin on lipid
peroxidation and tissue injury induced by myocardial ischemia reperfusion
injury in rats.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Methods</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">: Male Wistar
rats (250-300 g) were divided into 4 groups: control, control+ drug, diabetic
and diabetic+drug. Diabetes was induced by single injection of streptozotocin
(50 mg/kg intraperitoneally) and the diabetic period was 10 weeks. After 6
weeks of diabetes, treatment groups were received 150 mg/kg/day troxerutin in
distilled water by oral gavage for 4 weeks. The hearts were removed quickly,
mounted on Langendorff apparatus, and then subjected to 30-minutes regional
ischemia followed by 60-minutes reperfusion. The levels of lipd peroxidation
(MDA) of left ventricular supernatant and level of creatine kinase (CK) release
in coronary flow were measured by spectrophotometric method using special kits.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Results</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">: STZ increased
blood glucose in the diabetic group than in the control group. Troxerutin could
reduce blood glucose in diabetic group, but this reduction was not
statistically significant. MDA levels were increased in diabetic rats compared
to control ones and troxerutin treatment could reduce MDA levels in diabetic
group (p<0.05). Diabetes causes release of large amounts of CK compared to
the control group. TXR administration reduces the level of this enzyme in the
diabetic group.<o:p /></span></p><font size="3"><font face="Times New Roman">
<b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: AR-SA mso-fareast-font-family: "Times New Roman" mso-fareast-theme-font: minor-fareast mso-ansi-language: EN-US mso-fareast-language: EN-US">Conclusion</span></b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: AR-SA mso-fareast-font-family: "Times New Roman" mso-fareast-theme-font: minor-fareast mso-ansi-language: EN-US mso-fareast-language: EN-US">:
Troxerutin reduced lipid peroxidation and tissue injury probably by preventing
oxidative stress and activation antioxidative system especially in diabetic
rats and can have the protective effects on damage induced by myocardial
ischemia and reperfusion</span></font></font>
تروگزروتین, پراکسیداسیون لیپیدی, ایسکمی, رپرفیوژن, دیابت
Troxerutin, Lipd peroxidation, Ischemia, Reperfusion, Diabetes
37
45
http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1615&slc_lang=fa&sid=1
Fatemeh
Heidarzadeh
فاطمه
حیدرزاده
3900319475328460027443
3900319475328460027443
No
Tabriz University, Tabriz, Iran
دانشکده علوم طبیعی، دانشگاه تبریز، تبریز، یران
Reza
Badalzadeh
رضا
بدل زاده
3900319475328460027444
3900319475328460027444
Yes
Tabriz University of Medical Sciences, Tabriz, Iran
دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران
Homeira
Hatami
حمیرا
حاتمی
3900319475328460027445
3900319475328460027445
No
Tabriz University, Tabriz, Iran
دانشکده علوم طبیعی، دانشگاه تبریز، تبریز، ایران