Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1392
11
1
gregorian
2014
2
1
20
116
online
1
fulltext
fa
بررسی اثرات مکمل یاری با اسیدهای چرب لینولئیک کونژوگه بر فشار خون و ترکیب بدنی مردان جوان 20 تا 27 سال: یک کارآزمایی بالینی دوسوکور
Evaluation of the effect of conjugated linoleic acids supplementation on blood pressure and body composition of 20-27 year old males: A double-blind, placebo-controlled clinical trial
علوم تغذیه
Nutrition Sciences
پژوهشي
Research
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">:
درحالیکه اثر اسیدهای چرب لینولئیک کونژوگه (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">CLA (Conjugated Linoleic Acid</span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> <span lang="AR-SA"><font face="B Mitra" size="2">بر فشارخون و بهبود
ترکیب بدنی در بسیاری از مطالعات سلولی و حیوانی دیده شده است ولی نتایج مطالعات
انسانی بسیار متناقض است. هدف از اجرای این مطالعه تعیین اثر دو ماه مکمل یاری با </font></span></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">CLA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> بر فشارخون و ترکیب بدنی در پسران دانشجوی سالم است.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 2.85pt 0pt 0in text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">روش کار</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: این کارآزمایی بالینی دو سوکور با
تقسیم تصادفی روی 66 دانشجوی مرد سالم تمرین ندیده انجام شد. قبل و پس از مکمل
یاری هشت هفتهای با 4 کپسول هر یک حاوی 8/0 گرم </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">CLA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> و یا دارونما (روغن سویا)، توده بدون چربی و توده چربی بدن با روش
</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">BIA</span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> <span lang="AR-SA"><font face="B Mitra" size="2">(</font></span></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">bioelectrical</span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">impedance
analysis</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) اندازهگیری شد،
چربی احشایی و شکمی و دور کمر با استفاده از دستگاه </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">ViScan</span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> <span lang="AR-SA"><font face="B Mitra" size="2">اندازهگیری شد. فعالیت بدنی و رژیم غذایی افراد
به دلیل اینکه همگی در خوابگاه زندگی میکردند مشابه یکدیگر بود. آنالیزهای آماری
با استفاده از نرمافزار 16</font></span></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">SPSS</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>
انجام شد، و از آنالیزهای کوواریانس، آزمون </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">t</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> مستقل، آزمون </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">t</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> وابسته و آزمون
من ویتنی استفاده شد.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">یافتهها:</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"> </span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتایج
مطالعه نشان داد توده بدون چربی، توده چربی، چربی شکمی و احشایی، دور کمر و
فشارخون در مردان سالم جوان تمرین ندیده تحت تأثیر مکمل یاری با </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">CLA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> قرار نگرفتند.</span><span lang="FA" style="font-family: "B Mitra" font-size: 12pt mso-bidi-language: FA mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتیجه</span></b><b><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-size: 10.0pt" dir="ltr"></span></b><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">گیری</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">:
نتایج این مطالعه نشان داد که مکمل یاری با </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">CLA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> در مردان جوان سالم تمرین ندیده اثری بر ترکیب بدنی، چربیهای
شکمی و فشارخون ندارد.<o:p /></span></p><font face="Times New Roman" size="3"> </font>
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Background: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Although
the effect of <a name="OLE_LINK40"></a><a name="OLE_LINK39"><span style="mso-bookmark: OLE_LINK40"><font face="Times New Roman" size="3">Conjugated Linoleic Acids </font></span></a>(CLAs) on
blood pressure and body composition is revealed in several in vitro and animal
studies, the results of human studies are controversial. The purpose of the
current clinical double blind trial was to determine the effect of 2 months <a name="OLE_LINK38"></a><a name="OLE_LINK37"><span style="mso-bookmark: OLE_LINK38"><font face="Times New Roman" size="3">CLA
supplementation on blood pressure and body composition of non trained healthy
young male students</font></span></a>.</span><span style="font-size: 13pt mso-bidi-font-family: "B Mitra""><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Methods</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">: This
randomized, <a name="OLE_LINK42"></a><a name="OLE_LINK41"><span style="mso-bookmark: OLE_LINK42"><font face="Times New Roman" size="3">double-blind, placebo-controlled clinical trial
</font></span></a>was conducted on 66 non trained healthy male students. Before and after
eight weeks supplementation with 4</span><font size="3"><span style="font-family: Symbol font-size: 12pt mso-bidi-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">´</font></span></span><span style="font-family: "Times New Roman","serif" font-size: 12pt">0.8g.d-1
CLA or placebo (soybean oil), lean body mass and fat mass were measured with
BIA, trunk and visceral fat and waist circumference were measured with ViScan.
Physical activity amount and dietary intake of participants were similar
together, because they lived in dorms. Statistical analyses were performed
using the SPSS16 software, the statistical tests being analysis of covariance,
Independent sample t test, paired-sample t-test and Mann-Whitney U tests.<span lang="AR-SA" dir="rtl"><o:p /></span></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Results:</span></b><span style="font-size: 12pt mso-bidi-font-family: "B Mitra" mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><font face="Calibri"> </font></span><span style="font-family: "Times New Roman","serif" font-size: 12pt">CLA supplementation had no effect on
blood pressure, lean body mass, body fat mass, trunk and visceral fat and waist
circumference.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Conclusions: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">These results
show that CLA does not affect on body composition and blood pressure in non
trained young male students.<span lang="AR-SA" dir="rtl"><o:p /></span></span></p><font face="Times New Roman" size="3"> </font>
اسید لینولئیک کونژوگه، فشار خون، ترکیب بدنی، کاهش وزن، چربی شکمی
Conjugated linoleic acids, Blood pressure, Body composition, Weight loss, Trunk
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http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1498&slc_lang=fa&sid=1
Milad
Tajmanesh
میلاد
تاج منش
3900319475328460025120
3900319475328460025120
No
Iran University of Medical Sciences
دانشگاه علوم پزشکی ایران
Naheed
Aryaeian
ناهید
آریائیان
3900319475328460025121
3900319475328460025121
Yes
Iran University of Medical Sciences
دانشگاه علوم پزشکی ایران
Mostafa
Hosseini
مصطفی
حسینی
3900319475328460025122
3900319475328460025122
No
Tehran University of Medical Sciences
دانشگاه علوم پزشکی تهران
Reza
Mazaheri
رضا
مظاهری
3900319475328460025123
3900319475328460025123
No
Tehran University of Medical Sciences
دانشگاه علوم پزشکی تهران
Ramin
Kordi
رامین
کردی
3900319475328460025124
3900319475328460025124
No
Tehran University of Medical Sciences
دانشگاه علوم پزشکی تهران