fa اثر دریافت آب انار بر پروفایل چربی در بیماران مبتلا به کبد چرب غیر الکلی علوم تغذیه Nutrition Sciences پژوهشي Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: با توجه به نقش استرس اکسیداتیو در ایجاد کبد چرب غیر الکلی و کاهش آنتی اکسیدان های سرم در این بیماران، مطالعه حاضر با هدف بررسی اثر دریافت آب انار به همراه رژیم کاهش وزن، در این بیماران انجام گرفت.</span><span lang="FA" style="font-family: "B Mitra" font-size: 12pt mso-bidi-language: FA mso-fareast-font-family: SimSun"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">روش کار</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: در این کارآزمایی نیمه تجربی (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">IRCT: 201102232709N17</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>)، 35 بیمار داوطلب با تشخیص کبد چرب غیر الکلی انتخاب شدند. برای هر فرد در ابتدای مطالعه رژیم کاهش وزن تنظیم گردید. به مدت 3 ماه 1 لیوان آب انار (250 میلی لیتر) جایگزین 2 واحد میوه مورد نیاز افراد شد. دریافت های غذایی، فعالیت فیزیکی، شاخص های تن سنجی، غلظت لیپیدهای سرم و آنزیم های کبدی در ابتدا و انتهای مطالعه اندازه گیری شد. آنالیز آماری با استفاده از نرم افزار </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">SPSS</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> شماره 19 و آزمون های</span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span> paired t test</span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">و </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">Wilcoxon</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> انجام شد.</span><span lang="FA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">یافته‌ها:</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"> </span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">از بین 35 فردی که وارد پژوهش شدند، 33 نفر (9 زن و 24 مرد) مطالعه را به پایان رساندند. در پایان مطالعه کاهش معنی دار در وزن و نمایه توده بدن بیماران مشاهده گردید. دریافتآب انار به همراه رژیم غذایی منجر به کاهش معنی دار در آنزیم های کبدی و افزایش معنی دار در غلظت <span style="mso-spacerun: yes"><font face="B Mitra" size="2"> </font></span></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">HDL-C</span><span dir="rtl"></span><span style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> <span lang="AR-SA"><font face="B Mitra" size="2">(01/0</font></span></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p=</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) گردید. سایر متغیر های پروفایل چربی تغییر معنی دار نداشت.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتیجه</span></b><b><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-size: 10.0pt" dir="ltr">‌</span></b><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">گیری</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: نتایج این مطالعه نشان داد که دریافت آب انار به همراه رژیم غذایی کاهش وزن می تواند در بهبود وضعیت این بیماران و کاهش خطر بیماری های قلبی-عروقی در آنها موثر باشد.<o:p /></span></p><font face="Times New Roman" size="3"> </font> <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: ">Background: </span></b><span style="font-family: ">Regarding the role of oxidative stress in the pathogenesis of non alcoholic fatty liver disease and decrease of serum antioxidants concentration in these patients, this study was conducted to investigate the effect of pomegranate juice intake in weight loss diet of these patients. </span><span style="font-size: 12pt"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: ">Methods</span></b><span style="font-family: ">: In this quasi-experimental trial (IRCT: 201102232709N17), 35 patients with the diagnosis ofnon alcoholic fatty liver disease were selected. Initially, a weight loss diet was designed for each participant. One glass of pomegranate juice (250 mililiter) was substituted for required 2 servings of fruit for 3 months. Dietary intake, physical activity, anthropometric indices, and lipid profile before and after the study were measured. Statistical analysis<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>were carried out using SPSS 19.0 by Wilcox on and paired t tests.<span lang="AR-SA" dir="rtl"><o:p /></span></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: ">Results:</span></b><span style="font-family: "> From 35 participants, 33 (9 women and 24 men) completed the study. Pomegranate juice intake along with weight loss diet resulted in significant decrease in liver enzymes and increase in HDL-cholesterol (p= 0.01). Other lipid profile variables had no significant changes.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: ">Conclusions: </span></b><span style="font-family: ">According to the results of this study, pomegranate juice intake along with weight loss diet can be effective in improving clinical status of these patients and decreasing cardio-vascular risk.<span lang="AR-SA" dir="rtl"><o:p /></span></span></p><font face="Times New Roman" size="3"> </font> کبد چرب غیر الکلی، لیپوپروتئین ها، رژیم غذایی non-alcoholic fatty liver disease, lipoproteins, diet. 30 39 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1446&slc_lang=fa&sid=1 Golnaz Ekhlasi گلناز اخلاصی 3900319475328460023983 3900319475328460023983 No Iran University of Medical Sciences دانشگاه علوم پزشکی ایران Farzad Shidfar فرزاد شیدفر 3900319475328460023984 3900319475328460023984 Yes Iran University of Medical Sciences دانشگاه علوم پزشکی ایران Shahram Agah شهرام آگاه 3900319475328460023985 3900319475328460023985 No Iran University of Medical Sciences دانشگاه علوم پزشکی ایران Shahin Merat شاهین مرات 3900319475328460023986 3900319475328460023986 No Tehran University of Medical Sciences دانشگاه علوم پزشکی تهران Khanom Agha Fatemeh Hosseini خانم آغا فاطمه حسینی 3900319475328460023987 3900319475328460023987 No Tehran University of Medical Sciences دانشگاه علوم پزشکی تهران