fa مقایسه اثر روزه داری ماه رمضان و فعالیت ورزشی هوازی منظم بر شاخص‌های لیپوکالین 2 (LCN2)، پروفایل لیپیدی و مقاومت انسولینی افراد چاق غیر فعال طب ورزش Sports Medicine پژوهشي Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: هدف از این تحقیق مقایسه اثر روزه داری ماه رمضان (به عنوان یک الگوی رژیمی) و فعالیت ورزشی هوازی منظم بر شاخص‏های لیپوکالین-2 (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">LCN2</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>)، <a name="OLE_LINK62"></a><a name="OLE_LINK61"><span style="mso-bookmark: OLE_LINK62"><font face="B Mitra" size="2">پروفایل </font></span></a>لیپیدی و مقاومت انسولینی افراد چاق غیرفعال بود.</span><span lang="FA" style="font-family: "B Mitra" font-size: 12pt mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">روش کار</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: این تحقیق از نوع تحقیقات شبه تجربی با طرح اندازه‏های تکراری بود. در این مطالعه 18 مرد چاق 40 تا 50 ساله با نمایه توده بدنی بیش از 30 کیلوگرم بر متر مربع به صورت فراخوان عمومی جهت شرکت در این طرح تحقیقی از میان 70 داوطلب به طور تصادفی انتخاب شدند و پس از دارا بودن شرایط لازم به دو گروه روزه دار (9</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">N=</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) و گروه روزه‏دار و فعالیت ورزشی (9 </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">N=</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) تقسیم شدند. سپس در حالی که گروه روزه دار تنها روزه داری را به عنوان اثر مداخله‏ای انجام می‏داد، گروه روزه دار و فعالیت ورزشی علاوه بر روزه داری، فعالیت ورزشی را به صورت 27 جلسه در ماه انجام می‏دادند. جهت بررسی متغیرهای مورد نظر از افراد چهار نوبت متفاوت نمونه‏گیری خونی به عمل آمد. در نهایت جهت تجزیه و تحلیل داده‏ها از آمار اندازه‏های مکرر تحلیل واریانس در سطح <a name="OLE_LINK36"></a><a name="OLE_LINK35"><span style="mso-bookmark: OLE_LINK36"><font face="B Mitra" size="2">05/</font></span></a>0</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p<</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> استفاده گردید.</span><span lang="FA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-justify: inter-ideograph" dir="rtl"><b><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">یافته ها:</span></b><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"> </span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتایج تحقیق نشان داد که سطوح </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">LCN2</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> در هر دو گروه طی ماه رمضان کاهش می یابد. با این حال، این اثر کاهشی تنها در گروه روزه‏دار و فعالیت ورزشی معنادار بود (<a name="OLE_LINK38"></a><a name="OLE_LINK37"><span style="mso-bookmark: OLE_LINK38"><font face="B Mitra" size="2">05/0 </font></span></a></span><span style="mso-bookmark: OLE_LINK38"></span><span style="mso-bookmark: OLE_LINK37"></span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p<</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>). همچنین، میزان مقاومت انسولینی در هر دو گروه کاهش یافته بود که این کاهش در گروه روزه‏دار معنادار بود (05/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p<</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>). به علاوه، سطوح </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">LCN2</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> تنها در هفته چهارم ماه رمضان با مقادیر مقاومت انسولینی افراد چاق ارتباط معناداری داشت (05/0 </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p<</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>).</span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 12pt mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتیجه</span></b><b><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-size: 10.0pt" dir="ltr">‌</span></b><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">گیری</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: با توجه به نتایج تحقیق به نظر می‏رسد کاهش یافتن سطوح </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">LCN2</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> توسط روزه داری و همچنین روزه داری و فعالیت ورزشی عاملی در کاهش مقاومت انسولینی افراد چاق باشد.<o:p /></span></p><font face="Times New Roman" size="3"> </font> <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Background: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">The aim of this study was to compare the effects of fasting during Ramadan (</span><font size="3"><span style="font-family: "Times New Roman","serif"">as </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">a dietary pattern</span><span style="font-family: "Times New Roman","serif"">) </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">and regular aerobic exercise on LCN2</span><span style="font-family: "Times New Roman","serif"">, </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">lipid profile and insulin resistance indexes in non-active obese </span></font><span style="font-family: "Times New Roman","serif" font-size: 12pt">men.</span><span style="font-size: 13pt mso-bidi-font-family: "B Mitra""><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Methods</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">:</span><b><span style="font-size: 12pt mso-bidi-font-family: "B Mitra""><font face="Calibri"> </font></span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">This study was a semi-experimental research with a repeated measures design. In this study 18 obese men with a range of 40 to 50 years old and BMI over 30 kg per square meter after a public call among of 70 subjects were selected randomly. Subjects were divided into fasting (N=9) and fasting and exercise (N=9) groups</span><font size="3"><span style="font-family: "Times New Roman","serif"">.</span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> T</span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">he first group did only fasting and the second group did </span><span style="font-family: "Times New Roman","serif" font-size: 12pt">exercise </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">for 27 sessions</span><span style="font-family: "Times New Roman","serif" font-size: 12pt">i</span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">n addition to fasting</span><span style="font-family: "Times New Roman","serif"">.</span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt"> In order to evaluate the changes in the month of Ramadan</span><span style="font-family: "Times New Roman","serif"">, </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">blood samples were taken four different times</span><span style="font-family: "Times New Roman","serif"">. </span><span style="font-family: "Times New Roman","serif" font-size: 12pt">Repeated measures analysis of variance in the level of p <0/05 were used to analyse the data.<span lang="AR-SA" dir="rtl"><o:p /></span></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Results:</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt"> </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">Results showed that LCN2 levels in both groups decreased <a name="OLE_LINK34"></a><a name="OLE_LINK33"><span style="mso-bookmark: OLE_LINK34"><font face="Times New Roman" size="3">in </font></span></a>Ramadan <a name="OLE_LINK45"></a><a name="OLE_LINK44"><span style="mso-bookmark: OLE_LINK45"><font face="Times New Roman" size="3">month</font></span></a></span><span style="mso-bookmark: OLE_LINK45"></span><span style="mso-bookmark: OLE_LINK44"></span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">however</span><span style="font-family: "Times New Roman","serif" font-size: 12pt">, this </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">reduction was significant only in the fasting and exercise</span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> group (p<0/05). </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">Also</span><span style="font-family: "Times New Roman","serif" font-size: 12pt">, </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">both groups had decreased levels of insulin resistance</span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> that </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">significant reduction was noticed in the fasting</span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> group (p<0/05). </span><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">In addition, LCN2 levels in the fourth week of Ramadan was significantly associated with levels of insulin resistance in obese men</span><span style="font-family: "Times New Roman","serif" font-size: 12pt"> (p<0/05).<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Conclusions: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-font-size: 11.0pt">Results of the research showed that reduced levels of LCN2 by both fasting and exercise may lead to decrease of insulin resistance in obese men.<o:p /></span></p><font face="Times New Roman" size="3"> </font> لیپوکالین 2 (LCN2)، مقاومت انسولینی، فعالیت ورزشی، چاق Lipocalin-2 (LCN2), Insulin resistance, Exercise, Obese 16 29 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1445&slc_lang=fa&sid=1 Nahid Bijeh ناهید بیژه 3900319475328460023927 3900319475328460023927 No Ferdowsi University of Mashhad دانشگاه فردوسی مشهد Sadegh Abbasian صادق عباسیان 3900319475328460023928 3900319475328460023928 Yes University of Tehran دانشگاه تهران