fa اثر 4 هفته تمرین شنا بر روی استئوآرتریت زانوی موش صحرایی القا شده با تزریق مونوسدیم یدواستات طب ورزش Sports Medicine پژوهشي Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in -1.8pt 0pt -1.4pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">زمینه و هدف</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: استئوآرتریت (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">OA=</span><span dir="ltr"><a href="mw:C11:osteoarthritis"><span style="color: windowtext font-family: "Times New Roman","serif" font-size: 9pt text-decoration: none mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra" text-underline: none"><u>Osteoarthritis</u></span></a></span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) شایع­ترین بیماری مفاصل سینوویال می­باشد که افراد مسن در سرتاسر جهان را گرفتار می­کند و می­تواند به درد مزمن و ناتوانی شدید بیمار منجر شود. هدف از تحقیق حاضر بررسی اثر درمانی یک دوره تمرین شنا بر استئوآرتریت ناشی از مونو سدیم یدواستات (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">MIA= Monosodium Iodo Acetate</span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) در مفصل زانوی موش صحرایی نر بود.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in -1.8pt 0pt -1.4pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">روش­ کار</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: در تحقیق تجربی حاضر 18 سر موش صحرایی نر نژاد ویستار (میانگین وزن 173 ±1گرم، و سن 8 هفته) به طور تصادفی به سه گروه کنترل سالم، کنترل پایه و شنا تقسیم شدند. برای ایجاد استئوآرتریت تزریق درون ­مفصلی مونو سدیم یدواستات (50 میکرولیتر) در زانوی راست نمونه­ها انجام گرفت و در زانوی چپ آنها سالین تزریق شد. برنامه تمرینی این پژوهش شامل شنا با شدت متوسط و به مدت 28 روز بود. پس از اتمام دوره حیوانات را کشته و مفاصل زانوی هر دو پای آزمودنی­ها مورد بررسی هیستوپاتولوژیکی قرار گرفتند. از آزمون آماری تحلیل واریانس یک­طرفه (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">p<0/05</span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) و سپس آزمون تعقیبی توکی به منظور تجزیه و تحلیل کمی یافته­ها استفاده شد.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in -1.8pt 0pt -1.4pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">یافته­ها</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: نتایج به دست آمده نشان داد که شنا با شدت متوسط به مدت 4 هفته، اثر خوبی بر روی علائم استئوآرتریت زانوی موش­های صحرایی در 3 شاخص هیستوپاتولوژیکیِ نسبت عمق ضایعه (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">p=0/001</span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>)، عرض کل ناحیه­ی تخریب شده (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">p=0/001</span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) و عرض ناحیه­ی تخریب شده به طور معنی­دار (</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Mitra"" dir="ltr">p=0/001</span><span dir="rtl"></span><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>) گردید.</span><span lang="FA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in -1.8pt 0pt -1.4pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتیجه­گیری</span></b><span lang="FA" style="font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">: نتایج تحقیق حاضر نشان می­دهد که تمرین شنا با شدت متوسط، تأثیر مفیدی بر شدت زخم­های غضروفی ناشی از تزریق مونوسدیم یدواستات دارد. از این رو می­توان این<font size="2"><font face="B Mitra"><span style="mso-spacerun: yes"> </span>برنامهبرنامه را برای درمان استئوآرتریت زانو توصیه کرد.<o:p /></font></font></span></p><font face="Times New Roman" size="3"> </font> <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal vertical-align: top text-justify: kashida text-kashida: 0%"><b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA"><font size="3">Background</font></span></b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA"><font size="3">: Osteoarthritis is the most common form of synovial joint diseases which affect old people all around the world and can lead to chronic pain and severe disability.<span style="mso-spacerun: yes"><font face="Times New Roman"> </font></span></font><font size="3">The aim of present study was to investigate the therapeutic effect of swimming exercise on MIA-induced osteoarthritis in male rats’ knee joint.<o:p /></font></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA"><font size="3">Methods:</font></span></b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA"><font size="3"> Eighteen Wistar male rats (weight of 173±1 g, 8 weeks old) were randomly divided into 3 experimental groups: intact control, monosodium Iodoacetate (MIA) only and swimming. Intra-articular injection of MIA (50µl) was applied on rats’ right knee, similarly saline was injected in left knees. Training program used in the study was swimming with moderate intensity for 28 days. After the completion of the protocol, rats were killed and both knees of the animals were assessed histopathologically. One-way ANOVA (p<0/05) and post-hoc Tukey test were used for statistical<span style="mso-spacerun: yes"><font face="Times New Roman"> </font></span></font><font size="3">analysis of data.<o:p /></font></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><font size="3"><b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA">Results: </span></b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA">Results indicated that moderate swimming training for 4 weeks significantly improved osteoarthritic symptoms of rats’ knee in 3 histopathological measures of Depth Ratio of Lesions (p=0/001), Total Degeneration Width (p=0/001) and Significant Degeneration Width (P=0/001).<o:p /></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><font size="3"><b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA">Conclusion:</span></b><span style="font-family: "Times New Roman","serif" mso-ascii-theme-font: major-bidi mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-bidi-language: FA"> The findings of the present study showed that a moderate swimming training program exerts a beneficial influence on cartilage lesions induced by monosodium iodo acetate injection. Thus, the training protocol used in this study can be recommended for the treatment of osteoarthritis.<o:p /></span></font></p><font face="Times New Roman" size="3"> </font> تمرین شنا، استئوآرتریت زانو، مونوسدیم یدواستات، موش صحرایی. Swimming Training, Knee Osteoarthritis, Monosodium Iodoacetate, Rats. 83 91 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1381&slc_lang=fa&sid=1 Seyyed Hossein Mirkarimpour سید حسین میرکریم پور 3900319475328460022542 3900319475328460022542 Yes University of Tehran دانشگاه تهران Mohammad Hossein Alizadeh محمد حسین علیزاده 3900319475328460022543 3900319475328460022543 No University of Tehran دانشگاه تهران Mohammad Fallah Mohammadi محمد فلاح محمدی 3900319475328460022544 3900319475328460022544 No Guilan University دانشگاه گیلان Masoud Adibmoradi مسعود ادیب مرادی 3900319475328460022545 3900319475328460022545 No University of Tehran دانشگاه تهران Aydin Dilmaghanian آیدین دیلمقانیان 3900319475328460022546 3900319475328460022546 No University of Tehran دانشگاه تهران