fa بررسی علائم بالینی، یافته های آزمایشگاهی و میزان مرگ و میر نوزادان مبتلا به سپسیس بیماری‌های اطفال Pediatric Disease پژوهشي Research <p style="DIRECTION: rtl">  در این مطالعه شیوع علائم بالینی ، یافته های آزمایشگاهی و میزان مرگ و میر نوزادان مبتلا به سپسیس در 100 نوزاد با کشت خون مثبت بستری در بخش نوزادان بیمارستان حضرت علی اصغر (ع) بمدت 2 سال (70-1368)بررسی شده است. 56درصد بیماران در زمان بستری بیش از یک هفته (عفونت دیررس) و 44 </p><p style="DIRECTION: rtl">  درصد سن کمتر از یک هفته داشته اند (عفونت زودرس) . 67 درصد نوزادان پسر و 33 درصد دختر بوده اند. از نظر شیوع علائم بالینی : در 74درصد آنها رفلکسهای نوزادی کاهش یافته بود و سایر علائم بدین شرح  وجود داشته است : شیر نخوردن( 44درصد)، لتارژی( 34 درصد)،زردی (31درصد)، هیپوترمی(18درصد)، تحریک پذیری( 17 درصد) سایر علائم با شیوع کمتری وجود داشت. از نظر علائم آزمایشگاهی : در 22 درصد بیماران طولانی و بالاخره در 26 درصد  طولانی و بالا خره در 26 درصد PT لکوپنی، در 28 درصد باندمی، در 36 درصد ترومبوسیتوپنی، در 20 درصد طولانی وجود داشته است. PPT آنها از نظر پیش آگهی 82 درصد نوزادان با درمان مناسب بهبود یافته و بدون هیچ عارضه ای بیمارستان را ترک نموده اند. </p><p>  </p> <div style="mso-element: frame mso-element-frame-width: 347.25pt mso-element-frame-height: 317.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt"><tbody><tr><td style="BORDER-BOTTOM: #f0f0f0 BORDER-LEFT: #f0f0f0 PADDING-BOTTOM: 0in BACKGROUND-COLOR: transparent PADDING-LEFT: 0in PADDING-RIGHT: 0in BORDER-TOP: #f0f0f0 BORDER-RIGHT: #f0f0f0 PADDING-TOP: 0in" height="423" valign="top" align="left"><p style="TEXT-JUSTIFY: inter-ideograph TEXT-ALIGN: justify LINE-HEIGHT: 19.9pt TEXT-INDENT: 15.8pt MARGIN: 0.45pt 1.2pt 0pt 2.15pt mso-element: frame mso-element-frame-width: 347.25pt mso-element-frame-height: 317.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">In order to evaluate the frequency of clinical and laboratory findings of neonatal sepsis in Tehran, </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 11pt mso-font-width: 105%">a </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">retrospective study was carried out in 100 newborns who were admittedin newborn service of Ali Asghar Children Hospital with diagnosis of neonatal sepsis and eventually had positive blood cultures. <p></p></span></i></p><p style="TEXT-JUSTIFY: inter-ideograph TEXT-ALIGN: justify LINE-HEIGHT: 19.9pt TEXT-INDENT: 15.8pt MARGIN: 0.45pt 1.2pt 0pt 2.15pt mso-element: frame mso-element-frame-width: 347.25pt mso-element-frame-height: 317.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">56% of this patients were above </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt mso-font-width: 108%">1 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">week of age (late neonatal sepsis) and </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">44% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">were below </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">1 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">week (early neonatal sepsis). Among infected newborns, </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">67% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">were male and </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">33% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">were female. The frequency of clinical findings was: decreased reflexes </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">(74%), </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">poor feeding </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">44% , </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">lethargy 34%, Jaundice </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">31%, </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">hypothermia </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">25%, </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">respiratory distress </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">24% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 3.5pt mso-font-width: 92%">J </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">vomiting 19%, cyanosis </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">18% , </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">hyperthermia </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">18% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">and irritability 17%. <p></p></span></i></p><p style="LINE-HEIGHT: 19.9pt TEXT-INDENT: 14.85pt MARGIN: 0.45pt 4.8pt 0pt 0.7pt mso-element: frame mso-element-frame-width: 347.25pt mso-element-frame-height: 317.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">Other findings included: Leukopenia </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">22% , </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">increased band cells </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">28% , </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">thrombocytopenia </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">36%, </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">prolonged PIT </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">26% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">and PT 20% . <p></p></span></i></p><p style="LINE-HEIGHT: 19.9pt TEXT-INDENT: 14.85pt MARGIN: 0.45pt 4.8pt 0pt 0.7pt mso-element: frame mso-element-frame-width: 347.25pt mso-element-frame-height: 317.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">With early diagnosis and treatment </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9pt mso-font-width: 105%">82% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">of the patients recovered completely. <p></p></span></i></p></td></tr></tbody></table></div> 1- سپسیس نوزادی 2- عفونت زودرس 3- لکوپنی 4- مرگ و میر نوزادی 1) Sepsis 2) Leukopenia 3) Early neonatal sepsis 4) Late neonatal sepsis 248 253 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1206&slc_lang=fa&sid=1 A. Arab Mohammad Hosseini عبداله عرب محمد حسینی 3900319475328460021052 3900319475328460021052 Yes