fa اثرات ریفامپین و کلوگزاسیلین بر روی حاملین بینی استافیلوکوک طلائی در بیمارستان حضرت رسول اکرم(ص) بیماریهای داخلی Internal Medicine پژوهشي Research <p>  به منظور مقایسه بین ترکیب ریفا مپین و کلوگز اسیلین وهر یک از دو دارو به تنهائی در درمان ناقل بینی </p><p>  استافیلوکوک طلائی مطالعه حاضر بصورت کارازمایی بالینی دوسکور کاملا اتفاقی بر روی 45نفر از کارکنان </p><p>  بیمارستان حضرت رسول اکرم(ص) که ناقل بینی استافیلو کوک طلائی بوده اند انجام شده است.45 نفر بصورت </p><p>  اتفاقی به 3گروه 15نفره تقسیم شدند در یک گروه ترکیب ریفا مپین وکلوگز اسیلین،در گروه دیگر ریفامپین و </p><p>  دارونمای کلوگز اسیلین ودر گروه سوم کلوگز اسیلین ودارونمای ریفا مپین بکار برده شد. مدت مصرف داروها </p><p>  4روز بود. </p><p>  در بررسی نتایج،7نفر بدلیل متعدد در انتهای تحقیق از مطالعه خارج شدند واز 38 نفر باقیمانده،3هفته </p><p>  پس از اتمام مصرف داروها نمونه گیری بعمل امدکه در گروه اول از 14نفر تمام افراد کشت منفی داشتند </p><p>  (100درصد)در گروه دوم از 14نفر،10نفر کشت منفی داشتند(71درصد)ودر گروه سوم از 10 نفر،5نفر </p><p>  استفاده شد که KRUSKAL-WALLIS کشت منفی داشتند (50درصد)برای وجود اختلافبین سه گروه از تست </p><p>  استفاده شد که برای اختلاف MANN_WHITNEY بدست امد.در مقایسه بین گروها از تست (p<0.017) </p><p>  واختلاف (p<0.00036) گروه اول و دوم(29درصد)واختلاف گروه اول وسوم </p><p>  بدست امد. (p<0.29 گروه دوم و سوم (21درصد)( </p><p>  ترکیب ریفامپین وکلوگزاسیلین برای مدت 4روز یک ترکیب مناسب برای از بین بردن حالت ناقل </p><p>  استا فیلوکوک طلائی می باشد واین ترکیب نسبت به تجویز هر یک از دو دارو به تنهائی اثر بیشتری دارد ولی </p><p>  نتایج حاصله اجازه مقایسه بین ریفا مپین و کلوگز اسیلین هر کدام به تنهائی را نمی دهد. </p><p>  </p> <div style="mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt"><tbody><tr><td style="BORDER-BOTTOM: #f0f0f0 BORDER-LEFT: #f0f0f0 PADDING-BOTTOM: 0in BACKGROUND-COLOR: transparent PADDING-LEFT: 0in PADDING-RIGHT: 0in BORDER-TOP: #f0f0f0 BORDER-RIGHT: #f0f0f0 PADDING-TOP: 0in" height="479" valign="top" align="left"><p style="TEXT-JUSTIFY: inter-ideograph TEXT-ALIGN: justify LINE-HEIGHT: 17pt TEXT-INDENT: 14.85pt MARGIN: 0.45pt 0in 0pt 3.8pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">45 health personnels who were nasal carriers of staph aureus entered in this trial, seven subjects were omitted for various </span></i><i><span style="FONT-FAMILY: "Times New Roman","serif""><font size="3">reesos, </font></span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">remainders randomly divided </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt">to </span><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt mso-font-width: 114%">3 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">groups and were treated orally for </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt mso-font-width: 114%">4 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">days. <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- group I with rifampin </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 90%">& </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">cloxacilline <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- group 1/ with rifampin </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-font-width: 78%">& </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">placebo <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- group 11/ with cloxacilline </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 90%">& </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">placebo <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 16.8pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">All subjects were recultured </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 107%">3 ~eeks </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">after the completion of treatment. <p></p></span></i></p><p style="TEXT-JUSTIFY: inter-ideograph TEXT-ALIGN: justify LINE-HEIGHT: 17pt MARGIN: 0.2pt 1.65pt 0pt 2.85pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">In group I, all </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10.5pt">14 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">subjects were culture negative </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">(100% </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">cure), in group </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">1/10 </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">out of </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-font-width: 108%">14 </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">were culture negative </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-font-width: 108%">(71% </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">cure) and, in group 11/5 out of 10 </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">(50%), </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">were cultur negative. <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">K.K statistical analysis method gave </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 11.5pt">a </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">P<0.017. <p></p></span></i></p><p style="LINE-HEIGHT: 16.8pt TEXT-INDENT: 14.85pt MARGIN: 0.7pt 2.6pt 0pt 0.95pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">For comparison of three groups mamm-whitny test was used that yeilded following results: <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- difference between group I </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 90%">& </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">1/ (P<0.033)29% <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- difference between group I </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">& <i>II/(P< 0.036) 50% <p></p></i></span></p><p style="LINE-HEIGHT: 17pt MARGIN: 0in 0in 0pt 1.2pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">- difference between group </span></i><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">1/ </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 9.5pt">& <i>11/ (P<0.29)29% <p></p></i></span></p><p style="LINE-HEIGHT: 16.8pt TEXT-INDENT: 14.85pt MARGIN: 0.7pt 2.6pt 0pt 0.95pt mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">In conclusion, oral </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 107%">use </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">of rifampin and cloxacilline for four days is </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 107%">a </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">suitable combination for treatment of staph aureus carriers. <p></p></span></i></p><p style="LINE-HEIGHT: 17pt MARGIN: 0.2pt 3.1pt 0pt 0in mso-element: frame mso-element-frame-width: 346.55pt mso-element-frame-height: 359.0pt mso-element-wrap: auto mso-element-anchor-horizontal: margin mso-element-left: .05pt mso-element-top: .05pt mso-line-height-rule: exactly" class="Style"><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">*(comparision between the </span></i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt mso-font-width: 107%">use </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">of rifampin and cloxacillin alone was not possible due </span></i><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt">to </span><i><span style="FONT-FAMILY: "Arial","sans-serif" FONT-SIZE: 10pt">low number of subjects) <p></p></span></i></p></td></tr></tbody></table></div> 1- استافیلوکوک طلائی 2- ناقلین بینی 3- کلوگزاسیلین 4- ریفامپین Staph Aurues, Nasal Carriers, Cloxacillin, Rifampin 11 16 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1133&slc_lang=fa&sid=1 Seyed Jamaledin Sadjadi سیدجمال الدین سجادی 3900319475328460021233 3900319475328460021233 Yes Seyed Kamran Soltani Arabshahi سیدکامران سلطانی عربشاهی 3900319475328460021234 3900319475328460021234 No Kaveh Asadi کاوه اسدی 3900319475328460021235 3900319475328460021235 No