fa بررسی آلو آنتی ژنهای HLA-B، HLA-A و HLA-C در جمعیتی از استان اصفهان ایمنی‌شناسی Immunology پژوهشي Research <p>  ، <strong><i>HLA-A </i></strong><strong><i /></strong>شامل <strong><i>HLA </i></strong>تعداد 500 نفر از مردم اصفهان که از سلامتی کامل برخوردار بودند، از نظر آنتی ژنهای گروه یک<strong><i> </i></strong></p><p> <strong><i> </i></strong>مورد آزمایش قرار گرفتند. روش آزمایش به این شکل بود که در هر نمونه لنفوسیت ها از 5 میلی لیتر <strong><i>HLA-C </i></strong><strong><i /></strong>و <strong><i>HLA-B </i></strong></p><p> <strong><i> </i></strong>از نظر <strong><i>NIH </i></strong>خون وریدی جدا می شدند و با استفاده از روش استاندارد دو مرحله ای میکرولنفوسیتوتوکسیسیتی </p><p> <strong><i> </i></strong>تحت بررسی قرار می گرفتند. نتایج بدست آمده حاکی از آن است که شیوع <strong><i>HLA-C </i></strong><strong><i /></strong>و <strong><i>HLA-B </i></strong>، <strong><i>HLA-A </i></strong>آنتی ژنهای<strong><i> </i></strong></p><p> <strong><i> </i></strong>در جمعیت مورد مطالعه بیش از سایر <strong><i>HLA-CW </i></strong><strong><i>4 </i></strong><strong><i /></strong><strong><i /></strong>و <strong><i>B </i></strong><strong><i>35 </i></strong><strong><i /></strong><strong><i>، </i></strong><strong><i>HLA-B </i></strong><strong><i>5 </i></strong><strong><i /></strong><strong><i>، </i></strong><strong><i>A9 </i></strong><strong><i>، </i></strong><strong><i>A </i></strong><strong><i>3 </i></strong><strong><i /></strong><strong><i>، </i></strong><strong><i>A </i></strong><strong><i>2 </i></strong><strong><i /></strong><strong><i>، </i></strong><strong><i>HLA-A </i></strong><strong><i>1 </i></strong>آنتی ژنهای <strong><i /></strong><strong><i /></strong></p><p> <strong><i> </i></strong>در اصفهان مشابه با <strong><i>HLA </i></strong><strong><i /></strong>می باشد. بنابراین می توان گفت که شیوع آنتی ژنهای گروه یک <strong><i>HLA </i></strong>آنتی ژنهای گروه یک<strong><i> </i></strong></p><p>  شیوع آن در تهران و مشهد است. </p><p>  </p> <span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 9.5pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">A </span><i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">random sample of 500 healthy unrelated subjects from Esfahan province were HLA typed for </span></i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 9.5pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">A, 8 </span><i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">and </span></i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 9.5pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">C </span><i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">locus antigens. The lymphocytes were separated from </span></i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-font-width: 132% mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">5 </span><i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">ml of whole peripheral blood and were typed for HLA _ </span></i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">A, 8 <i>and </i>C <i>by using the standard two stage microlymphocytotoxicity NIH technique. The findings suggest that in the study population, frequency of HLA-Al' A</i></span><i>_{<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">2</span>}<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">, </span><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">A</span>_{<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">3</span>}<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">, </span><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">A</span>_{<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">g</span>}<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US"> </span><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">HLA-8s, </span></i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10.5pt mso-font-width: 156% mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">8_3S </span><i><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">and HLA-CW</span>_{<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">4</span>}<span style="LINE-HEIGHT: 115% FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US"> </span><span style="LINE-HEIGHT: 115% FONT-FAMILY: "Calibri","sans-serif" FONT-SIZE: 10pt mso-ascii-theme-font: minor-latin mso-fareast-font-family: 'Times New Roman' mso-fareast-theme-font: minor-fareast mso-hansi-theme-font: minor-latin mso-bidi-font-family: Arial mso-bidi-theme-font: minor-bidi mso-bidi-language: AR-SA mso-ansi-language: EN-US mso-fareast-language: EN-US">antigens is higher than other HLA antigens. It has been concluded that the destribution of HLA class I antigens in Esfahan is similar to their distribution in Tehran and Mashhad</span></i> 1- آنتی ژنهای اچ ال ای 2- توزیع اچ ال ای 3- عوامل زیستی و ایمنی 4- توزیع آنتی ژنهای گروه یک اچ ال ای 5- اصفهان HLA Antigens, HLA Distribution, Immunological and Biological Factors, HLA Calss I Distribution, Esfahan 94 96 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1123&slc_lang=fa&sid=1 Minoo Adib مینو ادیب 3900319475328460021408 3900319475328460021408 Yes Rasool Abolhasani رسول ابوالحسنی 3900319475328460021409 3900319475328460021409 No Edna Abkar Shahnazar ادنا آبکار شاه نظر 3900319475328460021410 3900319475328460021410 No