fa مقایسه سطح سرمی LP(a)‌با LDL، VLDL و HDL در بیماران مبتلا به انفارکتوس حاد میوکارد و آنژین صدری ناپایدار قلب و عروق Cardio Muscular Disease پژوهشي Research <b style="mso-ansi-font-weight: normal"><span lang="FA"><p></p></span></b><p></p><h4 dir="rtl"><span></span></h4><h4 dir="rtl"><span>    زمینه و هدف: بیماری‌های آنژین صدری پایدار و ناپایدار و انفارکتوس حاد میوکارد در اثر آترواسکلروز شریان کرونر اتفاق می‌افتند. هدف از این مطالعه مقایسه سطح لیپو پروتئین </span><span style="mso-bidi-language: FA" dir="ltr"><font face="Times New Roman">a</font></span><span style="FONT-FAMILY: " lang="FA">‌ با </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">LDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">VLDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> و </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">HDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> در بیماران مبتلا به انفارکتوس حاد میوکارد و آنژین صدری ناپایدار می‌باشد.</span><h4 dir="rtl"><span>روش بررسی: این مطالعه مقطعی بر روی بیمارانی که طی سال‌های 85 و 86 بدلیل انفارکتوس حاد میوکارد یا آنژین صدری ناپایدار در بیمارستان یحیی نژاد بابل بستری شده بودند انجام گردید. بیماران بر اساس مثبت یا منفی شدن ترپونین در دو گروه انفارکتوس حاد میوکارد و آنژین صدری ناپایدار تقسیم شدند. پس از انجام آزمایش لیپیدهای خون، اطلاعات در پرسشنامه‌ی تنظیم شده وارد گردید. سپس داده‌ها وارد نرم افزار </span><font face="Times New Roman"><span dir="ltr">SPSS </span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span><font face="B Yagut"><span style="mso-spacerun: yes"> </span>شده و توسط آزمون‌های </font></span><font face="Times New Roman"><span dir="ltr">chi-square</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> و </span><font face="Times New Roman"><span dir="ltr">T-Test</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> مورد تجزیه و تحلیل قرار گرفت. 05/0</span><span dir="ltr"></span><span dir="ltr"><span dir="ltr"></span><font face="Times New Roman"><</font></span><span dir="rtl"></span><span style="FONT-FAMILY: "><span dir="rtl"></span> </span><font face="Times New Roman"><span dir="ltr">P</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> معنی‌دار تلقی شد.<p></p></span></h4><h4 dir="rtl"><span>یافته‌ها: از 218 بیمار مورد مطالعه، 188 بیمار آنژین صدری ناپایدار و 30 بیمار انفارکتوس میوکارد داشتند. میانگین ایندکس‌های لیپید اندازه‌گیری شده </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">LDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 05/3</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>19/145، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">VLDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 48/1</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>89/30، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">LP(a)</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 31/5</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>15/65، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">TG</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 41/7</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>41/154، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">CHOL</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 68/3</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>41/221 و </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">HDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> 69/0</span><span dir="ltr"></span><span style="FONT-FAMILY: Symbol mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol" dir="ltr"><span dir="ltr"></span><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><span dir="rtl"></span><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>48/44 بود. در مقایسه‌ی میانگین لیپیدهای سرم در دو گروه، سطح </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">LDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">LP(a)</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>، </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">CHOL</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> و </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">HDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> اختلاف معنی‌‌داری داشت (05/0</span><span dir="ltr"></span><span style="mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman"><</font></span><span dir="rtl"></span><span style="FONT-FAMILY: "><span dir="rtl"></span> </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">P</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>). ولی در مورد </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">VLDL-C</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span> و </span><span style="mso-bidi-language: FA" dir="ltr"><font face="Times New Roman">TG</font></span><span style="FONT-FAMILY: " lang="FA">‌ اختلاف معنی‌داری مشاهده نشد (05/0</span><span dir="ltr"></span><span style="mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman">></font></span><span dir="rtl"></span><span style="FONT-FAMILY: "><span dir="rtl"></span> </span><font face="Times New Roman"><span style="mso-bidi-language: FA" dir="ltr">P</span><span dir="rtl"></span></font><span style="FONT-FAMILY: " lang="FA"><span dir="rtl"></span>).<p></p></span></h4><span><strong>نتیجه‌گیری:</strong> از این مطالعه‌ می‌توان نتیجه گرفت که رابطه‌ی معنی‌داری بین </span><span>LDL-C</span><span dir="rtl"></span><span dir="rtl" lang="FA"><span dir="rtl"></span> و کلسترول و </span><span>HDL-C</span><span dir="rtl"></span><span dir="rtl" lang="FA"><span dir="rtl"></span> پایین با </span><span>Lp(a)</span><span dir="rtl"></span><span dir="rtl" lang="FA"><span dir="rtl"></span> بالا در بیماران مبتلا به </span><span>UA</span><span dir="rtl"></span><span dir="rtl" lang="FA"><span dir="rtl"></span> و </span><span>AMI</span><span dir="rtl"></span><span dir="rtl" lang="FA"><span dir="rtl"></span> وجود دارد.</span> </h4> <p style="MARGIN: 0cm 0cm 0pt" class="Style2"><font face="Verdana"><strong></strong></font></p><p style="MARGIN: 0cm 0cm 0pt" class="Style2"><font face="Verdana"><strong>    Background & Aim: </strong>Stable and unstable angina and acute MI<span style="mso-spacerun: yes">  </span>happen due to atherosclerosis of coronary artery. The purpose of this study is comparing<span style="mso-spacerun: yes">  </span>the level of LP(a) with LDL-C, VLDL-C and HDL-C in patients with MI and unstable angina.</font></p><p style="MARGIN: 0cm 0cm 0pt" class="Style2"><font face="Verdana"><b>Patients and Method: </b>This cross-sectional study was performed on patients suffering from MI or unstable angina who were admitted to<span style="mso-spacerun: yes">  </span><p lace w:st="on" ><p lacename w:st="on" >Yahyanejad</placename /> <p lacetype w:st="on" >Hospital</placetype /></place /> in Babol between 2006 and 2007.The <span style="mso-spacerun: yes"> </span>patients were divided into MI group and unstable angina group based on the positive or negative result of troponin test. After<span style="mso-spacerun: yes">  </span>lipid profile test, information was recorded in a questionnaire. Then the data were analyzed by spss14, Chi-square<span dir="rtl"></span></font><span style="FONT-FAMILY: " dir="rtl"><span dir="rtl"></span> </span><font face="Verdana">and<span dir="rtl"></span></font><span style="FONT-FAMILY: " dir="rtl"><span dir="rtl"></span> </span><font face="Verdana">t-test. p<0.05 was considered significant.</font></p><p style="MARGIN: 0cm 0cm 0pt" class="Style2"><font face="Verdana"><b>Results: </b>Among 218 patients in this study, 188 patients suffered from unstable angina and 30 patients suffered from MI.The mean of serum lipids was: LDL-C= 145.19</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">3.05, <span style="mso-spacerun: yes"> </span>VLDL-C= 30.89</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">1.48, Lp(a)= 65.15</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">5.31, TG= 154.41</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">7.41, CHOL= 221.41</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">3.68,and HDL-C= 44.48</font><span style="FONT-FAMILY: Symbol mso-ascii-font-family: Verdana mso-hansi-font-family: Verdana mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">±</font></span></span><font face="Verdana">0.69. Comparing the means of serum lipids in both groups of MI and unstable angina revealed a significant difference between levels of LDL-C, Lp(a), cholesterol ,and HDL-C (p<0.05), but in terms of VLDL-C and TG the difference <span style="mso-spacerun: yes"> </span>was not significant (p>0.05).<span style="FONT-FAMILY: " dir="rtl" lang="AR-SA"></span></font><p></p><p style="MARGIN: 0cm 0cm 0pt" class="Style2"><font face="Verdana"><b>Conclusion: </b>It can be concluded that a significant correlation exists between LDL-C,<span style="mso-spacerun: yes">  </span>cholesterol, low HDL and high Lp(a) in patients with unstable angina and AMI. </font></p></p><p></p> کلیدواژه‌ها: 1- انفارکتوس حاد میوکارد 2- آنژین صدری ناپایدار 3- لیپوپروتئین a Key Words: 1)Acute Myocardial Infarction (AMI) 2)Unstable Angina 3)Lp(a) 56 62 http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-946&slc_lang=fa&sid=1 KH Amouzadeh خسرو عموزاده 3900319475328460016597 3900319475328460016597 Yes S Abrotan سعید ابروتن 3900319475328460016598 3900319475328460016598 No M Montazeri محمد منتظری 3900319475328460016599 3900319475328460016599 No M Montazeri محمود منتظری 3900319475328460016600 3900319475328460016600 No