TY - JOUR T1 - The effect of high Intensity Interval Training (HIIT) on adipsin, FGF21 and ABCA1 indices in obese men TT - اثر تمرین تناوبی شدید (HIIT) بر شاخص‌های آدیپسین، FGF21 و ABCA1 در مردان چاق JF - RJMS JO - RJMS VL - 28 IS - 3 UR - http://rjms.iums.ac.ir/article-1-6834-en.html Y1 - 2021 SP - 220 EP - 228 KW - High-intensity interval training (HIIT) KW - Adipsin KW - FGF21 KW - ABCA1 KW - Obese Men N2 - Background & Aims: In obese adults, the risk of metabolic syndrome is increased and obesity and inactivity are the causes of adipocytokine disorders and increased risk of cardiovascular disease in these people (2). Adipsin is one of these adipokines. The identification of adipsin as an important factor in diseases such as obesity and diabetes is not very old and the function of this protein is not yet fully known (4). However, the researchers found that the secretion of adipsin from adipose tissue triggers the synthesis of C3a, which is involved in the islets of Langerhans, where beta cells are present, stimulates insulin secretion and ultimately reduces hepatic glucose output. 5). Adipsin may also be indirectly associated with adipose tissue fat metabolism. This contradiction has caused the function of this protein to remain obscure until now (7). On the other hand, one of the organs that is directly related to obesity in the liver and fibroblast growth factor (FGF21) belongs to the subfamily hFGF (FGF19), FGF21, FGF23) (10), which is a key regulator. In maintaining energy homeostasis and metabolism of glucose and fat, so that its elimination impairs glucose homeostasis and weight gain (15) It has also attracted considerable attention as a molecule, a promising treatment for obesity and type 2 diabetes (16). Studies show that FGF21 levels are higher in obese people and develop a state of resistance to FGF21. However, anti-obesity measures of FGF21 seem to lead to weight loss by increasing the use of fats and reducing fat mass (17). Finally, it is believed that increased release of apolipoprotein-A and increased expression of ABCA1 in macrophages have a significant effect on the process of reverse cholesterol transport and plasma HDL-C formation and protect against atherosclerosis (23). Given the above and the importance and role of adipsin, FGF21 and ABCA1 in obesity and its associated complications, as well as the existence of conflicting results regarding the effect of exercise on these variables and insufficient information in this field, the question is whether intense intermittent exercise training on adipsin, Are fibroblast growth factor and ABCA1 effective in obese men? Methods: For the present applied and quasi-experimental research, among obese men with body mass index above 30 24 referring to Ilam Health House in the age range of 40-30 years, 24 people were randomly selected and divided into two groups of high intensity intermittent exercise (12 people). and control (n = 12) were divided. Then they practiced for 8 weeks and three sessions a week in such a way that the subject walked 20 meters for 30 seconds at maximum speed in a round trip and then walked for 30 seconds. The exercise in the first week consisted of 4 repetitions of activity and 4 rests, in the following weeks one activity and one rest were added each week. Blood samples were taken from the brachial vein in fasting conditions 24 hours before the start of the protocol and 48 hours after the end of the protocol after 8 weeks. Finally, descriptive statistics, Shapiro-Wilk tests and univariate analysis of covariance (ANKOVA) were used to analyze the data. Results: The results showed that high-intensity intermittent exercise (HIIT) caused a significant increase in adipsin, FGF21 and ABCA1 in obese men. Conclusion: The results showed that high-intensity intermittent exercise increased FGF21 in obese men. Consistent with this finding, Khalfi et al. (2015) investigated the effect of high-intensity intermittent exercise on serum levels of irzin and fibroblast growth hormone 21 (FGF21) and insulin resistance in obese male rats. The results showed that in the HIIT group compared to OC levels of irisin and FGF21 increased significantly, while MICT had no significant effect on both hormones (27). In another study in the same field, Toloui Azar et al. (2015) examined the effect of high-intensity interval training on serum levels of fibroblast growth factor 21, insulin resistance and lipid profile in inactive obese women. Based on the results of the present study, it seems that HIIT training with increasing 21FGF values may play an effective role in glucose homeostasis, reduce fat mass and increase energy consumption and be considered to prevent obesity and improve insulin resistance index (18). Another finding of the present study indicates a significant increase in ABCA1 in obese men. In connection with this finding, Gandmani et al. (2015) investigated the effect of eight weeks of intermittent and continuous endurance training on MicroRNAs associated with reverse cholesterol transfer in elderly Wistar rats. The results showed an increase in ABCA1 mRNA expression in the two training groups compared to the control group, but this increase was greater in periodic training than in continuous training, which is consistent with the present results (30). M3 ER -