TY - JOUR T1 - The effect of 12 weeks water-based Tabata training on insulin resistance, apolipoprotein A and apolipoprotein B in obese women with polycystic ovary syndrome TT - تاثیر 12 هفته تمرین تاباتا در آب بر مقاومت به انسولین، آپولیپوپروتئین A و آپولیپوپروتئین B در زنان چاق مبتلا به سندرم تخمدان پلی کیستیک JF - RJMS JO - RJMS VL - 28 IS - 5 UR - http://rjms.iums.ac.ir/article-1-6485-en.html Y1 - 2021 SP - 11 EP - 20 KW - Water-based Tabata training KW - Apolipoprotein A KW - Apolipoprotein B KW - Polycystic ovary syndrome N2 - Background & Aims: Polycystic ovary syndrome is the most common endocrine disorder of the reproductive system in women. It is associated with some diseases such as insulin resistance, type 2 diabetes, endometrial hyperplasia, increased risk of cardiovascular disease, depression and sometimes mental disorders (2). Insulin resistance is currently a common feature of polycystic ovary syndrome, which puts women at risk for type 2 diabetes, coronary artery disease, high blood pressure and obesity. According to research, 70% of women with this complication have insulin resistance (4). Insulin resistance leads to an increase in insulin levels, which stimulates androgen production in the ovarian stroma and impairs follicular development (5). In addition, research has shown that in people with polycystic ovary syndrome, some cardiovascular risk factors such as apolipoproteins (6) are also affected, which due to the mechanisms of this disease, this change in balance is formed. Research suggests that the most important way to prevent and treat infertility disorders in people with polycystic ovary syndrome is to control their diabetes and weight (16). Although the benefits of aerobic exercise have been proven in many studies, little research has been done on intense intermittent exercise. One type of intense intermittent exercise is the Tabata exercise (5). Numerous clinical studies have reported significant aerobic, metabolic, musculoskeletal, and psychological benefits for water sports programs and intermittent swimming exercises (22). Considering the above and the importance of treating polycystic ovary syndrome on the one hand and the importance of angiogenesis on the other hand, the researcher intends to investigate the effect of Tabata exercise in water and metformin on endostatin and in obese women with polycystic ovary syndrome. Methods: The present research is a quantitative and applied study that was conducted with a two-group design (experimental and control) with pre-test and post-test. The statistical population of the present study consisted of all women with a body mass index of more than 29.9 in Isfahan with polycystic ovary syndrome. 30 people were selected as a sample from the community and provided they met the inclusion criteria, which were randomly assigned to the experimental group of Tabata + metformin exercise control. Subjects then completed a personal information questionnaire and blood samples were taken after 12 hours of night fasting to determine the level of research variables. In the continuation of the experimental group, the training program consisted of 12 weeks, 3 sessions per week and each session lasted 40 minutes of Tabata training in water with a special training song for 20 minutes and 10 minutes of stretching and cooling exercises. The dose of metformin prescribed in the experimental group was 500 mgr twice a day after breakfast and dinner. 48 hours after the last training session, blood samples were taken again from all subjects. Descriptive statistics and Shapiro-Wilk tests, one-way analysis of variance and Tukey's post hoc test were used to analyze the data using SPSS / 21 software at the significance level of 0.05. Results: The results showed that exercise (F = 27.424, P = 0.001, µ = 0.329) and the interaction of exercise and time (F = 5.865, P = 0.019, µ = 0.095) had a significant effect on adiponectin in obese women with polycystic ovary syndrome. But time had no significant effect on adiponectin in obese women with polycystic ovary syndrome (F = 0.001, P = 0.972, µ = 0.001). It was also found that insulin resistance at the end of the period was significantly lower in the exercise group than the control group (P = 0.0001). In relation to apolipoprotein A, exercise (F = 0.099, P = 0.754, µ = 0.002), time (F = 1.645, P = 0.205, µ 0.029) and exercise-time interaction (F = 1.213, P = 0.275) were determined. µ = 0.021) had no significant effect on the amount of apolipoprotein A in obese women with polycystic ovary syndrome. Other findings showed exercise (F = 1.138, P = 0.291, µ = 0.020), time (F = 0.585, P = 0.448, µ = 0.010) and exercise-time interaction (F = 0.713, P = 0.402, µ = 0.013 ) Have no significant effect on the amount of apolipoprotein B in obese women with polycystic ovary syndrome. Conclusion: The results of the present study showed that 12 weeks of Tabata exercise program in water led to a significant reduction in insulin resistance in obese women with polycystic ovary syndrome. This finding of the present study is consistent with the results of research by Harrison et al. (2012) and Esmailzadeh Tolouei et al. (2015) (20-21). Probably the reason for the decrease in insulin resistance in the present study is a decrease in factors such as weight, body mass index and fat percentage in these people after exercise. Regarding apolipoprotein A, it can be said that apolipoprotein A catalyzes low-density lipoprotein in the blood vessel wall of the body, especially the vascular wall of adipose tissue, by activating the enzyme lipoprotein lipase. In sports activities, low-density lipoprotein catabolism develops. Therefore, it is necessary to increase apolipoprotein A, but since the increase in low-density lipoprotein was not significant in this study, the lack of increase in lipopathological catabolism ¬ can be considered a reason for not increasing apolipo protein A. On the other hand, it has been suggested that the increase threshold of apolipo protein A is to exercise more than one hour per session and more than twelve weeks (26). However, the training protocol was followed in the study for 12 weeks, which could be one of the reasons why apolipo protein A did not change. Finally, the fact that apolipoprotein B levels do not decrease following Tabata exercises in the present study may be justified by the fact that LDL levels do not decrease. It seems that controlling the diet by consuming less foods with high or high glycemic index and instead consuming foods with low or medium glycemic index can have a positive effect on the amount of apolipoprotein B (29). Therefore, by controlling this nutritional factor, positive changes of apolipoprotein B can be achieved after exercise. However, in the present study, subjects did not follow a specific diet. A period of Tabata training did not cause a significant change in apolipoprotein B levels in obese women with polycystic ovary syndrome. M3 ER -