TY - JOUR JF - RJMS JO - RJMS VL - 25 IS - 12 PY - 2019 Y1 - 2019/3/01 TI - The effect of an 8-week resistance training on ActRIIβ in fast- and slow-twitch skeletal muscles and plasma levels of GDF8, GDF11 and GASP-1 in old male rats TT - تأثیر هشت هفته تمرین مقاومتی بر ActRIIB عضله اسکلتی تند و کند انقباض و سطوح پلاسمایی GDF8، GDF11 و GASP-1 در رت‌های نر پیر N2 - Background: Changing the concentration of growth factors and their receptors can affect sarcopenia (age-related muscular atrophy). The aim of this study was to determine the effects of an 8-week resistance training on ActRIIβ in fast- and slow-twitch (FT & ST) skeletal muscles and plasma levels of GDF8, GDF11 and GASP1 in old male rats. Methods: This study was conducted as a two-group experimental design with 14 old male rats with age range 24 to 27 months and weighing 440±24g. After the familiarization training, the rats were randomly divided into 2 groups of 7 control and training. The training protocol was included 8 weeks climbing from a 1 meter ladder. 5cc blood was taken from the left ventricle, 48 hours after the last session, for measurement of GDF8, GDF11 and GASP-1 by ELISA method. The soleus (SOL) muscle (ST) and flexor hallucis longus (FHL) muscle (FT) of rats were taken for measurement of ActRIIB by IHC method. Independent t-test was applied for statistical analysis of the data (p<0.05). Results: Comparisons between groups showed that 8-week resistance training have a significant effects on GDF11 (p=0.001), GDF8/GDF11 (p=0.001), GDF8 (p=0.027) and ActRIIβ in SOL muscle (p=0.013), but no between-groups differences were observed in GASP-1 (p=0.704) and ActRIIβ in FHL muscle (p=0.325). Conclusion: It seems that resistance training can reduce sarcopenia by favorable effects on growth factors and their receptors. However, more studies are needed in this regard. SP - 104 EP - 115 AU - Masoudian, Behnam AU - Azamian Jazi, Akbar AU - Faramarzi, Mohammad AU - Talebi, Ardeshir AD - Shahrekord University, Shahrekord, Iran KW - Resistance Training KW - ActRIIβ KW - GDF11 KW - GDF8 KW - GASP-1 KW - Old UR - http://rjms.iums.ac.ir/article-1-5339-en.html ER -