RT - Journal Article T1 - Miswak sticks’ extract anti-inflammatory properties in carrageenan test JF - RJMS YR - 2019 JO - RJMS VO - 25 IS - 10 UR - http://rjms.iums.ac.ir/article-1-5368-en.html SP - 38 EP - 45 K1 - Salvadora persica L. K1 - Anti-inflammatory Effect K1 - Carrageenan K1 - Rats AB - Background: Miswak is the product of Salvadora persica L. that has antibacterial, antifungal, antiplasmudium, anticonvulsant, and gastroprotective properties. In this study, the anti-inflammatory effect of aqueous extract of miswak sticks (Salvadora persica L.) was investigated in carrageenan-induced rat paw edema. Methods: Adult male rats were divided into five groups, receiving normal saline, indomethacin (5 mg/kg), extract of Salvadora persica L. (50, 75, and 100 mg/kg), intraperitoneally. Then, carrageenan was injected into plantar surface of paw, and edema was measured using a micrometer in different times. Results: Salvadora persica L. extract at dose of 50 mg/kg reduced inflammation at 4 and 5 hours after carrageenan injection (p<0.05). Doses of 75 mg/kg (p<0.01) and 100 mg/kg (p<0.001) of this extract exerted anti-inflammatory effects at 4, 5, and 6 hours after carrageenan injection. Indomethacin also decreased edema, significantly compared to saline-injected group (p<0.0001). Conclusion: Our data revealed that Salvadora persica L. extract possesses anti-inflammatory properties. However, further experiments on the possible use of this plant in inflammatory disorders are required. LA eng UL http://rjms.iums.ac.ir/article-1-5368-en.html M3 ER -