TY - JOUR JF - RJMS JO - RJMS VL - 24 IS - 160 PY - 2017 Y1 - 2017/10/01 TI - vitamin D receptor gene polymorphisms and risk of coronary artery disease: findings from a meta-analysis with 5259 cases TT - بررسی ارتباط پلی مورفیسم‌های‌ شایع ژن گیرنده ویتامین D با خطر ابتلا به بیماری عروق کرونر قلب: شواهد حاصل از یک مطالعه متاآنالیز با 5259 مورد بیمار N2 - Background:Previous studies evaluating the association between ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene (VDR) and risk of coronary artery disease (CAD) have produced inconsistent results. The present meta-analysis of eligible studies was conducted to reveal whether this polymorphism plays a role in susceptibility to CAD. Methods: Literature search of Medline and EMBASE databases were conducted to identify all eligible studies. Odd ratios (OR) and their corresponding 95% confidence intervals (CIs) were calculated to assess the strength of association in the dominant model, recessive model, allelic model, homozygotes contrast, and heterozygote contrast. Results: a total of nine case-control studies with 5259 CAD cases and 1981 healthy controls were included in this meta-analysis. Overall, we found no significant association between the ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene and CAD risk in any genetic model tested (P ˃ 0.05). Moreover, in subgroup analysis by ethnicity, no significant association was evident between these polymorphisms and susceptibility to CAD in Caucasians and east-Asians in all models. Conclusion: This meta-analysis suggests that ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene might not be associated with susceptibility to CAD. Further studies are needed to confirm our results. SP - 79 EP - 89 AU - alizadeh, shahab AU - Hassani, Hossein AU - alizadeh, hamzeh AU - jafarian, Kurosh AD - Tehran University of Medical Sciences KW - vitamin D receptor KW - polymorphism KW - coronary artery disease KW - meta-analysis UR - http://rjms.iums.ac.ir/article-1-4662-en.html ER -