TY - JOUR T1 - Comparison of the Efficacy of Transdermal Fentanyl in the Treatment of Chronic Soft Tissue Cancer Pain with Placebo in a Double Blind Randomized Clinical Trial TT - مقایسه اثربخشی چسب فنتانیل بین جلدی در درمان درد مزمن بیماران مبتلا به سرطان بافت نرم در مقایسه با دارونما در یک کارآزمایی بالینی تصادفی شده دو سوکور JF - RJMS JO - RJMS VL - 16 IS - 0 UR - http://rjms.iums.ac.ir/article-1-1271-en.html Y1 - 2009 SP - 0 EP - 0 KW - Transdermal fentanyl patch KW - Chronic pain KW - Soft tissue malignancy N2 -   Background and Aim: Pain due to cancer is one of the major problems of patients affected by malignancies. There are many methods for management of cancer pain and opioid consumption is the most important method. Fentanyl is a synthetic opioid which is represented as a transdermal patch used for chronic cancer pain relief. In this study we evaluated the effectiveness of transdermal fentanyl patch as compared to placebo in cancer pain.   Patients and Methods: This study was designed and performed as a double blind randomized clinical trial. Patients affected by soft tissue tumors with chronic pain who had referred to Cancer institute of Imam Khomini Hospital during 2006-07 were included and divided randomly into transdermal fentanyl patch and placebo groups. The appearance of the patches in both groups was the same. Pain severity was measured with Visual Analogue Scale(VAS) 24, 48 and 72 hours after the initiation of treatment. Data analysis was done by SPSS V. 13 software.Quantitative data were shown with mean(SD) and qualitative data were presented with frequency. Chi- square and t-tests were used for comparison of the data between the two groups.Repeated measurement analysis of variance was used for evaluating the effect of time and its relation with the medicine. p M3 ER -