TY - JOUR T1 - Study of the Correlation between Acetaminophen Consumption and CSF Glucose in Febrile Convulsion TT - ارتباط مصرف استامینوفن با قند مایع نخاع در تب و تشنج JF - RJMS JO - RJMS VL - 16 IS - 0 UR - http://rjms.iums.ac.ir/article-1-1231-en.html Y1 - 2009 SP - 0 EP - 0 KW - CSF Glucose KW - Acetaminophen KW - Febrile Convulsion N2 -    Background & Aim : Hyperglycemia and hyperglycorrha ch ia are common associations of febrile seizures. Rapid release of cortisol and adrenaline after seizures as a stress reaction induces elevated glucose concentration. During fever release of interleukin-1 beta, an endogenous pyrogenic cytokine, inhibits insulin release and stimulates the secretion of cortisol. This may explain the correlation between CSF glucose concentration and body temperature in the present report . The purpose of our study was to assess the correlation between acetaminophen consumption and CSF glucose in febrile convulsion.   Patients and Method : In this cross-sectional analytic study ,we analyzed CSF samples taken from 63 children with febrile convulsion whose ages ranged from 3 to18 months. Comaprisons between the mean CSF glucose concentrations in the children who had taken and not taken acetaminophen within 6 hours before convulsion were made using Students' t-test and Mann-whitney test.   Results: CSF glucose levels were significantly higher (P =0. . 0001) in children who had not taken acetaminophen (82±8 mg/dL, n =) as compared with children who had taken acetaminophen (53±4 mg/dL, n=).   Conclusion: The use of acetaminophen decreases CSF glucose concentration in febrile convulsive children. M3 ER -