@ARTICLE{Pazoki Toroudi, author = {Pazoki Toroudi, H.R and Tavakkoli Hosseini, M and Tahergorabi, Z and }, title = {The Effect of Water Immersion Stress on Late Phase Isolated Stomach Fundus Strip Motility of Rat}, volume = {13}, number = {50}, abstract ={    Background & Aim: Gastric ulcer is the result of imbalance between the effect of protective and destructive factors on gastric mucosal layer. There are so many proposed destructive factors including acid, bile, nonsteroidal anti-inflammatory drugs(NSAIDS) and increased gastric motility. In this study we examined the time course effect of water immersion stress on gastric motility. Material & Methods: Male wistar rats were immersed in 20-25˚C water for 2 hours. After water immersion the rats were sacrificed at 30 min, 1 h, 6 h, 12 h and 24 h intervals and the stomaches were excised. Transverse strips of the fundus region were prepared and placed in organ bath containing modified Krebs solution perfused with carbogen gas(95% O2, 5% CO2) at 37˚C. The contractile activity of the strip was recorded using an isotonic transducer(preload 2g) on NarcoBioSystem physiograph. The amplitude and frequency of the spontaneous contractions were compared to their relevant control groups using student t-test(Pvalue }, URL = {http://rjms.iums.ac.ir/article-1-561-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-561-en.pdf}, journal = {Razi Journal of Medical Sciences}, doi = {}, year = {2006} }