TY - JOUR T1 - A STUDY OF NATURAL OCCURRING ANTICOAGULANT AND ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH HISTORY OF THROMBOSIS IN TEHRAN TT - بررسی سطح مهارکننده‌های طبیعی انعقاد و آنتی‌فسفولیپید آنتی بادی در بیماران با سابقه ترمبوز عروقی در شهر تهران JF - RJMS JO - RJMS VL - 9 IS - 29 UR - http://rjms.iums.ac.ir/article-1-281-en.html Y1 - 2002 SP - 266 EP - 272 KW - 1) Thrombosis 2) Antithrombin 3) Protein C 4) Protein S 5) Antiphospholipid antibodies N2 - ABSTRACT Thrombophilia is a clinical problem throughout the world and it is particularly a major problem in western countries. Factors causing thromboembolic diseases are numerous and they may be inherited or aquired. In order to investigate causes of venous thrombosis. The level of antithrombin (AT), protein C, protein S and the presence of antiphospholipid antibodies (APA) in 300 patients with a history of thrombosis measured. The activity of AT was examined by chromogenic, protein C and protein S by clotting assaies and APA was also detected using ELISA method. A deficiency in one or more of natural anticoagulant determined in 35 out of 156 patients (22.43%) without receiving anticoagulant drugs and 87 out of 144 patients (60.41%) with a recent history of anticoagulant therapy. A significant differences (P M3 ER -