RT - Journal Article T1 - Adult Still’s disease (ASD) JF - RJMS YR - 2015 JO - RJMS VO - 22 IS - 132 UR - http://rjms.iums.ac.ir/article-1-3886-en.html SP - 63 EP - 72 K1 - Adult Still’s disease K1 - systemic inflammatory disorder AB - Adult Still's Disease (ASD) is an uncommon systemic inflammatory disorder of unknown etiology and pathogenesis characterized by high quotidian fever accompanied by systemic manifestations. There is no single diagnostic test for AOSD diagnosis is often clinical, and it is always necessary to exclude common disease mimics such as infections, malignancies and other rheumatic diseases. Ferritin and glycosylated ferritin are useful adjuncts to aid in the diagnosis of ASD. Treatment aims at both minimizing inflammation and halting disease progression. Non-steroidal anti-inflammatory drugs have limited efficacy so glucocorticoids in conjunction with disease-modifying antirheumatic drugs such as methotrexate are also used. Novel therapeutic approaches such as anti-tumor necrosis factor blockade, interleukin-1 (IL-1), interleukin-6 inhibitors and monoclonal antibodies are promising. LA eng UL http://rjms.iums.ac.ir/article-1-3886-en.html M3 ER -