TY - JOUR T1 - Assessment of the Role of Dexamethasone on Modulation of Acute and Chronic Pain and its Comparison with Stress Analgesic Effect in Formalin Test in Mice TT - ارزیابی نقش دگزامتازون در کاهش درد حاد و مزمن و مقایسه آن با استرس در مدل تست فرمالین در موش سوری JF - RJMS JO - RJMS VL - 11 IS - 39 UR - http://rjms.iums.ac.ir/article-1-121-en.html Y1 - 2004 SP - 91 EP - 96 KW - Key Words: 1) Acute and chronic Pain 2) Dexamethasone N2 - A few studies have shown that stress and glucocorticoids probably interfere in pain control. The aim of this study was to investigate the role of dexamethasone(Dex) as a glucocorticoid receptor agonist on acute and chronic pain in formalin test in mice. In this study male albino mice(n=60) in 6 groups(25-30gr) were used. Dex ( 0.5, 1 and 2mg/kg) was injected 30 min before test and stress (St) was caused by 1-min swimming in cold water(18–22˚). Also, formalin test was performed 3 min after inducing St in St groups and 30 min after injection of Dex in Dex+St groups. Indices of signs were licking and foot elevation for assessment of acute pain(5 min) and chronic pain(15-40 min) after injection of formalin 5%(25µl) in right paw. Findings indicated that Dex had analgesia effect in duration of acute and chronic phases compared with control group and St was more effective than Dex effect. The present data provide further evidence for important role of glucocorticoids on relief of acute and chronic pain(P M3 ER -