RT - Journal Article T1 - The Effects of Vitamin C on Lipoproteins, Apo A-I, Apo B, Malondialdehyde(MDA) and the Assessment of its Interaction with Copper in Hyperlipidemic Patients JF - RJMS YR - 2004 JO - RJMS VO - 11 IS - 39 UR - http://rjms.iums.ac.ir/article-1-117-en.html SP - 59 EP - 67 K1 - Key Words: 1) Vitamin C 2) Lipoproteins 3) Copper 4) Hyperlipidemic AB - Epidemiological studies showed protective effect of vitamin C on improvement of serum lipoproteins and decrease of coronary heart disease(CHD), but its interaction with copper absorption and metabolism is also reported. The aim of the present study was to determine the effects of vitamin C on lipoproteins and its interaction with copper in hyperlipidemic patients. In a double blind placebo trial of parallel design study, 36 hyperlipidemic patients(total cholesterol(TC) and triglyceride(TG) greater than 200 mg/dl) were randomly assigned into two groups to receive daily 500mg vitamin C (study group) or placebo(control group) for 10 weeks. Fasting blood samples were collected at the beginning and at the end of the period. TG, TC, LDL-C, HDL-C were measured enzymatically, apo B and apo A-I immunoturbidometerically, MDA and vitamin C colorimetrically, serum copper via atomic absorption spectroscopy and plasma ceruloplasmin(CP) enzymatically. The obtained data which were analyzed by t-test, paired t-test, chi square and ANOVA, showed that in vitamin C group there was a significant decrease at the end of study in TC, apo B and MDA compared to initial value(P=0.004, P=0.005, P LA eng UL http://rjms.iums.ac.ir/article-1-117-en.html M3 ER -