RT - Journal Article T1 - Ulcerogenic Effect of Prednisolone on Rat Gastric Mucosa and Role of Neutroohils JF - RJMS YR - 1999 JO - RJMS VO - 6 IS - 2 UR - http://rjms.iums.ac.ir/article-1-1769-en.html SP - 107 EP - 115 K1 - Digestive System Diseases K1 - Prednisolone K1 - Peptic Ulcer K1 - Stomach Diseases K1 - Neutrophi K1 - Stomach Ulcer K1 - Gastric Ulcer AB - The ulcerogenic effect of corticosteroids has always been subject of controversial discussion. In this study, which is a part of another extensive study (the role of neutrophil in induction of gastric mucosal injury by different agents), the effect of prednisolone, as a widely used corticosteroid, on the rat gastric mucosa, was investigated. Prednisolone (1 mg/kg) induced acute mucosal injury (after 3 hours) in special regions of the rat stomach. Moderate neutropenia, induced by methotrexate, significantly reduced the prednisolone induced injury. Profound neutropenia induced by anti-neutrophil serum, completely prevented the induction of injury by prednisolone. A specific muccosal area of the rat stomach is quite similar to the mucosa of the esophagus. Neutropenia also diminished the ulcerogenic effect of prednisolone in this area. These findings suggest a role of neutrophil in induction of gastric, and probably eosophageal acute mucosal injury by prednisolone in rat. LA eng UL http://rjms.iums.ac.ir/article-1-1769-en.html M3 ER -