TY - JOUR JF - RJMS JO - RJMS VL - 17 IS - 78 PY - 2010 Y1 - 2010/12/01 TI - Study of bone turnover markers and inflammatory disease activity in rheumatoid arthritis patients visiting Rheumatology Clinic of Loghman Hospital during 2008-09 TT - بررسی ارتباط سطح سرمی مارکرهای ساخت و تخریب استخوانی با فعالیت التهابی بیماری در بیماران مبتلا به آرتریت روماتوئید مراجعه کننده به بیمارستان لقمان حکیم طی سال 88 – 1387 N2 -   Background: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting 0.5 to 1% of the general population worldwide. The cause of RA remains unknown. In active RA, bone turnover markers change in serum and urine before the appearance of erosions in radiography. In this study, we compared RA activity index with bone turnover marker levels in serum of RA patients.   Methods: In this cross-sectional study, RA patients referring to the Rheumatology Clinic of Loghman Hospital were studied. One hundred fourteen established RA patients were included. Bone turnover markers were measured in 75 patients. DAS28 and cumulative dose of steroid were calculated in all patients. RF, Anti-CCP, ESR, CRP, bone turnover markers consisting of osteocalcin, P1NP, βCTX and ALP were measured for all the patients. Cases were divided based on whether steroid and DMARD were used or not. Comparison of DAS28 and bone turnover markers was done with Chi square Pearson test. Also, the relation between bone turnover markers and consumption of DMARDs, steroid and bisphosphonate was evaluated. SPSS V. 16 was also used for data analysis.   Results: There was significant correlation between DAS28 and serum osteocalcin (p SP - 1 EP - 10 AU - Ahmadzadeh, A AU - Moslemizadeh, M AU - M Imam, M AU - Rajaee, A.R AU - Shafiezadeh, M AU - Azargashb, E AU - Enteshari, K AD - Shaheed Beheshti University of Medical Sciences KW - Rheumatoid arthritis KW - DAS28 KW - Bone turnover markers KW - Osteoporosis UR - http://rjms.iums.ac.ir/article-1-1601-en.html ER -