Research code: مقاله مستخرج از رساله است
Ethics code: IR.IAU.TABRIZ.REC.1402.107
Clinical trials code: مقاله مستخرج از رساله است
Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran , divar71@yahoo.com
Abstract: (683 Views)
The skin is the largest organ in the body in terms of surface area and has various functions. One of the most common injuries to the skin is open wounds caused by cuts and injuries. One of the most important issues for researchers has always been to find a way to heal wounds. Today, herbal treatment is very much studied by researchers in the field of wound healing due to the possibility of less side effects. Cloud pomegranate white seed extract is probably effective in wound healing due to its antibacterial and anti-inflammatory properties.On the other hand, some studies show the antibacterial properties of zinc oxide nanoparticles in local use and reduce contamination and infection in the wound, and suggest re-epithelialization as the most important mechanism of wound healing in this substance. In this research, an attempt was made to investigate the healing effects of zinc oxide nanoparticles in the form of an ointment, the alcoholic extract of white pomegranate seeds in the form of an ointment, and the combined ointment of the two compared to the effects of the control group and Oserin. In this study, twenty-five mice were selected and randomly assigned to five treatment groups. The first group did not receive any medication, the second group received Oserin ointment, the third group received white pomegranate seed extract as an ointment, and the fourth group received zinc oxide nanoparticles. Ointment face and the fifth group received alcoholic extract of white pomegranate seeds along with zinc oxide nanoparticles. Photographs were taken of the wounds created on days 0, 7, 14, and 21 and the extent of wound healing was calculated. On days 0, 1, 3, 7, 14, and 21, mice were killed painlessly and samples were taken from the wounds. Histopathological examinations were performed on the samples collected from the wound. At the end of the study, the amount of mononuclear cells, multinucleated cells, fibroblast and vascularization in the fifth group was less than other groups. The process of wound contraction in the fifth group was more than other groups. Although, in the fifth and fourth groups, the process of wound contraction was more severe than the other groups. Complete healing of the wound was observed on the 21st day only in the fifth group. In this study, the topical application of white pomegranate seed extract along with zinc oxide nanoparticles extract had a positive effect on the stages of wound healing in mice, and therefore it may have a beneficial role on wound healing.
Keywords: histopathology, wound healing, alcoholic extract of white pomegranate seeds, zinc oxide nanoparticles, Syrian mice
Type of Study: Research |
Subject:
veterinarian
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