Volume 30, Issue 6 (9-2023)                   RJMS 2023, 30(6): 0-0 | Back to browse issues page

Research code: IR.SSRC.REC.1399.128
Ethics code: IR.SSRC.REC.1399.128

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Saebi F, Abednatanzy H, Azarbayjani M, Gholami M. The effect of HIIT and Royal Jelly on RBP4 and AMPK gene expression in soleus muscle and insulin resistance in type 2 diabetic rats. RJMS 2023; 30 (6)
URL: http://rjms.iums.ac.ir/article-1-7135-en.html
Science and research branch, Islamic Azad University, Tehran, Iran , abednazari@gmail.com
Abstract:   (326 Views)
Background :Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand.RBP4 is one of these adipokines whose serum concentrations increase in different models of rats with type 2 diabetes and people with insulin resistance or type 2 diabetes . The aim of this study was to study changes in RBP4 gene expression in soleuse mascle and insulin resistance index after HIIT and Royal Jelly in obese type 2 diabetic rats. Methods: The statistical subject consisted of wistar rats. After a 20 weeks high-fat diet by intraperitoneal injection of 25 mg STZ per kg body weight they became diabetic. Rats with fasting glucose between 150 and 400 mg / dL were considered to have type 2 diabetes. HIIT protocol and gavage performed for eight weeks, five sessions per week with 2-minute alternation of 2 and 8 intervals with 80 to 90% vo2max and a one-minute rest cycle with 50 to 56% vo2max. Royal Jelly was given by gavage at a dose of 100 mg / kg 5 days a week. Results: Data analysis using two-way analysis of variance test showed that in comparison with the control group, HIIT led to a significant reduction in glucose and insulin resistance index.so data shown that a non-significant decrease in soleuse mascle RBP4 gene expression compared to the control group and HIIT and royal jelly increased the expression of soleus muscle AMPK gene compared to the control group, which was significant in the HIIT group (P = 0.008).
Conclusion: HIIT and royal jelly resulted in decrease in soleuse mascle RBP4 gene expression and HIIT and royal jelly increased the expression of soleus muscle AMPK gene compared to the control group that is important in consumption glucose in diabetic subject.
Type of Study: Research | Subject: Exercise Physiology

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