Volume 24, Issue 160 (10-2017)                   RJMS 2017, 24(160): 79-89 | Back to browse issues page

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alizadeh S, Hassani H, alizadeh H, jafarian K. vitamin D receptor gene polymorphisms and risk of coronary artery disease: findings from a meta-analysis with 5259 cases. RJMS 2017; 24 (160) :79-89
URL: http://rjms.iums.ac.ir/article-1-4662-en.html
Tehran University of Medical Sciences , sh_alizadeh@razi.tums.ac.ir
Abstract:   (3857 Views)

Background:Previous studies evaluating the association between ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene (VDR) and risk of coronary artery disease (CAD) have produced inconsistent results. The present meta-analysis of eligible studies was conducted to reveal whether this polymorphism plays a role in susceptibility to CAD.
Methods: Literature search of Medline and EMBASE databases were conducted to identify all eligible studies. Odd ratios (OR) and their corresponding 95% confidence intervals (CIs) were calculated to assess the strength of association in the dominant model, recessive model, allelic model, homozygotes contrast, and heterozygote contrast.
Results: a total of nine case-control studies with 5259 CAD cases and 1981 healthy controls were included in this meta-analysis. Overall, we found no significant association between the ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene and CAD risk in any genetic model tested (P ˃ 0.05). Moreover, in subgroup analysis by ethnicity, no significant association was evident between these polymorphisms and susceptibility to CAD in Caucasians and east-Asians in all models.
Conclusion: This meta-analysis suggests that ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene might not be associated with susceptibility to CAD. Further studies are needed to confirm our results.

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Type of Study: review article | Subject: Cardio Muscular Disease

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