Male sexual disorder includes hypoactive sexual desire disorder, male erectile disorder, premature ejaculation and male orgasmic disorder. Premature ejaculation is the most common problem. Premature ejaculation could have an effect on the various aspects of the quality of life including emotional happiness, interpersonal relationship, and social behavior. One of the important aspects of premature ejaculation is definition of this problem and explanation to the individuals. Currently, various treatments are available for premature ejaculation consistent with psychological/behavioral management and pharmacotherapy. Serotonin Specific Reuptake Inhibitors (SSRIs) especially dapoxitin, are first-line pharmacotherapy; however tramadol might be used for unresponsive premature ejaculation. New therapeutic approaches are being researched including modafinil, botulinum toxin, acupuncture and circumcision.