Background: One of the most important bilirubin nervous receptors is N-Methyl-D-Aspartate (NMDA). Some parents believe that the aqueous solution of sugar reduces the bilirubin serum level in newborns. In this work, the relationship between newborns jaundice and the levels of serum calcium and blood sugar was investigated.

Methods: This descriptive analytical study was performed on 102 icteric newborns above 2500 gram weight and without any basic disease hospitalized for six month. Bilirubin, calcium and blood sugar determinations were performed with spectrophotometer and benmary devices, diazo solutions A and B, methanol, dyed solution, calcium standard, addition glucose indicator and standard. Results were analyzed with SPSS software.

Results: 55.9% newborns were boys and 44.1% were girls. There was significant relationship between calcium and indirect bilirubin (p< 0.1, r= 0.193) in 90% confidence level. Jaundice resulting from deficiency in breast milk, was observed in 94.11% of the newborns. There was no significant relationship between blood sugar and indirect bilirubin (p>0.1, r=‑0.048) in 90% confidence level. Also, there was no significant relationship between gender and blood sugar (p> 0.1, r= -0.039) and calcium (p> 0.1, r= 0.030) in 90% confidence level.

Conclusion: Increase in bilirubin, increases total calcium serum level and relationship between blood sugar and bilirubin was not meaningful