Background: Long-term chronic diseases such as AIDS, cancer and heart disease affect patients’ attitude, always create crises in individuals’ life. The main purpose of this study was to compare the situation resiliency and depression in cardiac patients with healthy People.

Methods: During a descriptive of causal–comparative study and using convenience sampling 106 cardiac patients (58 women and 48 men) were selected from Motahari Hospital in Jahrom city in 2013. Also 102 healthy volunteers (52 females and 50 males) based on demographic variables matched with the patient groups were selected. Beck Depression Inventory  and Resiliency Scale and Connor Davison were administered to participants. Data based on level of 95%  were analyzed using SPSS v.16.

Finding: Independent t-test revealed a significant increase in depression scores and significant reduction in resiliency between people with heart disease and normal samples (p<0.001). In addition, analysis of variances revealed that women are better than men at resiliency (p<0.003). The education level was positively associated with resiliency in coping with the diseases (p<0.011).

Conclusion: resiliency plays mediating role in heart disease outset, and its low levels are as a risk factor for people with cardiovascular disease.