Abstract Objectives: The aim of the current study is to investigate the relationship of thought Action Fusion, experiential avoidance and responsibility with obsessive–compulsive Symptoms in nonclinical population. Method: A sample of 200 students of Malayer University was selected through convenience sampling method and completed the following questionnaires: Thought Fusion Instrument (TFI), Acceptance and Action Questionnaire (AAQ-II), Responsibility Attitude Scale Obsessive-Compulsive Inventory-Revised. Data were analyzed using Pearson correlation and multiple regression analysis. Results: Results from stepwise regression showed that thought Action Fusion, experiential avoidance and responsibility entered in the model as predictors. Predictors had different weights in predicting symptoms. Predictive equation is reported for obsessive-compulsive symptoms in students. Conclusion: Based on the research results use of metacognitive therapy and acceptance and commitment therapy in the treatment of OCD is suggested.