Background: The control of parenchymal hemorrhage especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to compare the hemostatic effect of calcium sulfate and ferric sulfate on controlling the bleeding from liver parenchymal tissue.

Methods: In this animal model study 60 male wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured using calcium sulfate and ferric sulfate different concentrations (15%, 25%, and 50%). Finally, the obtained data were entered into SPSS software and analyzed using Kruskal-wallis test, Mann – Whitney, Kolmogorov – Smirnov and also Wilcoxon signed ranks test.

Results: In all groups we had complete hemostasis. The hemostasis time of calcium sulfate concentration groups was significantly less than that of the ferric sulfate group (p<0.01).

Conclusion: Calcium sulfate and ferric sulfate can control liver bleeding and both are effective hemostatic agents in controlling liver parenchymal tissue hemorrhage in an animal model.