Volume 20, Issue 113 (11-2013)                   RJMS 2013, 20(113): 29-37 | Back to browse issues page

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Mazandaran University
Abstract:   (6145 Views)

Background:Amyloid-beta (Aβ), is one of the risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running with Allium paradoxum supplementation on plasma Amyloid beta1-42 in the diabetic rats induced with Alloxan.


Methods: In this laboratory experimental study 28 male ratsweighing 185±1 gm were randomly assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) peritoneally. The traininggroup participated in voluntary wheel running for 6 weeks.




Results:Sixweeks of voluntary wheel running significantly increased the plasma Aβ1-42 levels in training group compared with control group (P<0.001). Also Aβ1-42 levels increased in training-Allium group in comparison with control group (P=0.029) and Allium (P=0.025). Nevertheless, plasma Aβ1-42 levels was not different between training-Allium and training (P=0.210) and Allium (P=0.944) groups. 


Conclusion:The plasma Aβ1-42 levels of diabetic subjects  was increased following 6 weeks of voluntary exercise combined with Allium Paradoxum extract supplementation, but understanding the beneficial effects of this increase in plasma 1-42 levels requires more studies.

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Type of Study: Research | Subject: Exercise Physiology

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