Volume 19, Issue 103 (1-2013)                   RJMS 2013, 19(103): 18-25 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rabiei Z, Bigdeli M R, Mohagheghi F, Rasoulian B, Sharifi A. Effect of dietary olive leaf extract on brain cholesterol, cholesterol ester and triglyceride levels and of brain edema in rat stroke model. RJMS 2013; 19 (103) :18-25
URL: http://rjms.iums.ac.ir/article-1-2345-en.html
Shahrekord University of Medical Sciences
Abstract:   (7533 Views)

  Background : Brain injury by transient complete global brain ischemia (cardiac arrest) and regional incomplete brain ischemia (ischemic stroke) afflicts a very large number of patients with death or permanent disability. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury.

  Methods: The aim of the study was to evaluate the effect of dietary Olive Leaf Extract (OLE) on brain cholesterol, cholesterol ester and triglyceride levels as well as brain edema in rat stroke model.

  Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30 days (50, 75 and 100 mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle Cerebral Artery Occlusion (MCAO)-operated (n=6) and intact subgroups (n=6) for assessment of neuropathology (brain edema) and brain lipid analysis.

  Results: The brain cholesterol, cholesterol ester and triglyceride levels were greater in experimental groups when compared to controls. Olive leaf extracts reduced brain edema in experimental groups of 75 and 100 mg/kg/day.

  Conclusion: Our data suggest that OLE may be cerebroprotective in a rat model of ischemia-reperfusion. Further work is required to extend these observations.

Full-Text [PDF 319 kb]   (3741 Downloads)    
Type of Study: Research | Subject: Physiology

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb